STRINGSTRING
GBA2 GBA2 LATS1 LATS1 MYADM MYADM CDC42EP4 CDC42EP4 PRKCE PRKCE LOC102148861 LOC102148861 ARF6 ARF6 PFN3 PFN3 ESAM ESAM CDC42EP2 CDC42EP2 RASA1 RASA1 VASP VASP TMOD1 TMOD1 MLST8 MLST8 CSF3 CSF3 TMSB4X TMSB4X SSH3 SSH3 ARPC5L ARPC5L SPTBN4 SPTBN4 GRB2 GRB2 PYCARD PYCARD BAG4 BAG4 VIL1 VIL1 FCHSD2 FCHSD2 SPTB SPTB BAIAP2L1 BAIAP2L1 NPHS1 NPHS1 SPTBN5 SPTBN5 ADD1 ADD1 TMOD2 TMOD2 LOC100063059 LOC100063059 PFN4 PFN4 AVIL AVIL TLR9-2 TLR9-2 ABITRAM ABITRAM SSH2 SSH2 LMOD2 LMOD2 PDE1B PDE1B HCLS1 HCLS1 SPTBN1 SPTBN1 ARFGEF1 ARFGEF1 CAPZA1 CAPZA1 KANK3 KANK3 FLII FLII FCHSD1 FCHSD1 BAIAP2L2 BAIAP2L2 ARPC5 ARPC5 TMOD4 TMOD4 ARHGAP40 ARHGAP40 ARPC3 ARPC3 PFN1 PFN1 TMOD3 TMOD3 LMOD1 LMOD1 CAPZA2 CAPZA2 SPTA1 SPTA1 CCL26 CCL26 CDC42EP3 CDC42EP3 PRKCD PRKCD SPTBN2 SPTBN2 TWF1 TWF1 MTPN MTPN CARMIL1 CARMIL1 ADD2 ADD2 CORO1A CORO1A HAX1 HAX1 PIK3R2 PIK3R2 PTK2B PTK2B BBS4 BBS4 SNX9 SNX9 RICTOR RICTOR CYFIP1 CYFIP1 SCIN SCIN GSN GSN NCK2 NCK2 CCL24 CCL24 SVIL SVIL SSH1 SSH1 VILL VILL PFN2 PFN2 CAPZB CAPZB CAPG CAPG RDX RDX LOC111773936 LOC111773936 ENSECAP00000032476 ENSECAP00000032476 EPS8 EPS8 CYFIP2 CYFIP2 CAPZA3 CAPZA3 ENSECAP00000036024 ENSECAP00000036024 DLG1 DLG1 ARHGAP18 ARHGAP18 EVL EVL TMSB15B TMSB15B ENSECAP00000039507 ENSECAP00000039507 ADD3 ADD3 FAM49A FAM49A CRACD CRACD LMOD3 LMOD3 CDC42EP5 CDC42EP5 PAK3 PAK3 ENSECAP00000041482 ENSECAP00000041482 MKKS MKKS CDC42EP1 CDC42EP1 SLIT2 SLIT2 ARPC2 ARPC2 KANK4 KANK4 PLEKHG2 PLEKHG2 KANK1 KANK1 BAIAP2 BAIAP2 LOC111773934 LOC111773934 CTTN CTTN FAM49B FAM49B SPTAN1 SPTAN1 ARHGAP28 ARHGAP28 DBNL DBNL DLG2 DLG2 ENSECAP00000049244 ENSECAP00000049244 MTOR MTOR SPTBN4-2 SPTBN4-2 ARPC4 ARPC4 DMTN DMTN ARPC1B ARPC1B C15orf62 C15orf62 LOC100147550 LOC100147550 ELN ELN HIP1R HIP1R
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GBA2Non-lysosomal glucosylceramidase; Non-lysosomal glucosylceramidase that catalyzes the hydrolysis of glucosylceramide (GlcCer) to free glucose and ceramide. (922 aa)
LATS1Large tumor suppressor kinase 1. (1128 aa)
MYADMMyeloid associated differentiation marker. (322 aa)
CDC42EP4CDC42 effector protein 4. (335 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
LOC102148861Profilin; Belongs to the profilin family. (153 aa)
ARF6ADP ribosylation factor 6; Belongs to the small GTPase superfamily. Arf family. (175 aa)
PFN3Profilin; Belongs to the profilin family. (137 aa)
ESAMEndothelial cell adhesion molecule. (393 aa)
CDC42EP2Cdc42 effector protein 2; Probably involved in the organization of the actin cytoskeleton; Belongs to the BORG/CEP family. (214 aa)
RASA1RAS p21 protein activator 1. (1041 aa)
VASPVasodilator stimulated phosphoprotein; Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration. Belongs to the Ena/VASP family. (385 aa)
TMOD1Tropomodulin 1. (359 aa)
MLST8MTOR associated protein, LST8 homolog. (326 aa)
CSF3Colony stimulating factor 3. (204 aa)
TMSB4XHematopoietic system regulatory peptide; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization (By similarity); Belongs to the thymosin beta family. (100 aa)
SSH3Slingshot protein phosphatase 3. (764 aa)
ARPC5LActin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (153 aa)
SPTBN4Spectrin beta, non-erythrocytic 4. (893 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
PYCARDPYD and CARD domain containing. (195 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
VIL1Villin 1. (827 aa)
FCHSD2FCH and double SH3 domains 2. (764 aa)
SPTBSpectrin beta chain; Belongs to the spectrin family. (2331 aa)
BAIAP2L1BAI1 associated protein 2 like 1. (520 aa)
NPHS1NPHS1 adhesion molecule, nephrin. (1327 aa)
SPTBN5Spectrin beta, non-erythrocytic 5. (3664 aa)
ADD1Adducin 1. (771 aa)
TMOD2Tropomodulin 2. (351 aa)
LOC100063059SCY domain-containing protein. (131 aa)
PFN4Profilin; Belongs to the profilin family. (129 aa)
AVILAdvillin. (816 aa)
TLR9-2Toll-like receptor 9. (349 aa)
ABITRAMActin binding transcription modulator. (181 aa)
SSH2Slingshot protein phosphatase 2. (1450 aa)
LMOD2Leiomodin 2. (158 aa)
PDE1BNCK associated protein 1 like. (1182 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (498 aa)
SPTBN1Spectrin beta chain; Belongs to the spectrin family. (2364 aa)
ARFGEF1ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)
CAPZA1F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (286 aa)
KANK3KN motif and ankyrin repeat domains 3. (820 aa)
FLIIFLII actin remodeling protein. (1270 aa)
FCHSD1FCH and double SH3 domains 1. (692 aa)
BAIAP2L2BAI1 associated protein 2 like 2. (512 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
TMOD4Tropomodulin 4. (345 aa)
ARHGAP40Rho GTPase activating protein 40. (446 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
PFN1Profilin; Belongs to the profilin family. (166 aa)
TMOD3Tropomodulin 3. (352 aa)
LMOD1Leiomodin 1. (575 aa)
CAPZA2F-actin-capping protein subunit alpha-2; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity). (286 aa)
SPTA1Spectrin alpha, erythrocytic 1. (2428 aa)
CCL26C-C motif chemokine. (94 aa)
CDC42EP3CDC42 effector protein 3. (254 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
SPTBN2Spectrin beta chain; Belongs to the spectrin family. (2390 aa)
TWF1Twinfilin actin binding protein 1. (384 aa)
MTPNMyotrophin. (118 aa)
CARMIL1Capping protein regulator and myosin 1 linker 1. (1432 aa)
ADD2Adducin 2. (724 aa)
CORO1ACoronin; Belongs to the WD repeat coronin family. (461 aa)
HAX1HCLS1-associated protein X-1; Recruits the Arp2/3 complex to the cell cortex and regulates reorganization of the cortical actin cytoskeleton via its interaction with KCNC3 and the Arp2/3 complex. Slows down the rate of inactivation of KCNC3 channels. Promotes GNA13-mediated cell migration. Involved in the clathrin-mediated endocytosis pathway. May be involved in internalization of ABC transporters such as ABCB11. May inhibit CASP9 and CASP3. Promotes cell survival. May regulate intracellular calcium pools. (284 aa)
PIK3R2Uncharacterized protein. (479 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
BBS4Bardet-Biedl syndrome 4. (531 aa)
SNX9Sorting nexin. (621 aa)
RICTORRPTOR independent companion of MTOR complex 2. (1732 aa)
CYFIP1Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1225 aa)
SCINScinderin. (735 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
NCK2Cytoplasmic protein. (380 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
SVILSupervillin. (2262 aa)
SSH1Slingshot protein phosphatase 1. (1073 aa)
VILLVillin like. (857 aa)
PFN2Profilin; Belongs to the profilin family. (188 aa)
CAPZBF-actin-capping protein subunit beta; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (357 aa)
CAPGCapping actin protein, gelsolin like. (446 aa)
RDXRadixin. (625 aa)
LOC111773936F-actin-capping protein subunit alpha; F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments. (298 aa)
ENSECAP00000032476Uncharacterized protein. (242 aa)
EPS8Epidermal growth factor receptor pathway substrate 8. (867 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
CAPZA3Capping actin protein of muscle Z-line subunit alpha 3. (298 aa)
ENSECAP00000036024Profilin; Belongs to the profilin family. (109 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
ARHGAP18Rho GTPase activating protein 18. (664 aa)
EVLEnah/Vasp-like. (494 aa)
TMSB15BThymosin beta; Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization. Belongs to the thymosin beta family. (45 aa)
ENSECAP00000039507Uncharacterized protein. (57 aa)
ADD3Adducin 3. (706 aa)
FAM49AFamily with sequence similarity 49 member A. (406 aa)
CRACDKIAA1211. (1409 aa)
LMOD3Leiomodin 3. (624 aa)
CDC42EP5CDC42 effector protein 5. (153 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
ENSECAP00000041482Profilin; Belongs to the profilin family. (103 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
CDC42EP1CDC42 effector protein 1. (367 aa)
SLIT2Slit guidance ligand 2. (1543 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
KANK4KN motif and ankyrin repeat domains 4. (1011 aa)
PLEKHG2Pleckstrin homology and RhoGEF domain containing G2. (1423 aa)
KANK1KN motif and ankyrin repeat domains 1. (1433 aa)
BAIAP2BAI1 associated protein 2. (670 aa)
LOC111773934F-actin-capping protein subunit alpha-3. (298 aa)
CTTNCortactin. (559 aa)
FAM49BFamily with sequence similarity 49 member B. (494 aa)
SPTAN1Spectrin alpha, non-erythrocytic 1. (2787 aa)
ARHGAP28Rho GTPase activating protein 28. (728 aa)
DBNLDrebrin like. (565 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
ENSECAP00000049244Uncharacterized protein. (631 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
SPTBN4-2Uncharacterized protein. (675 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
DMTNDematin actin binding protein. (405 aa)
ARPC1BActin related protein 2/3 complex subunit 1B. (437 aa)
C15orf62Chromosome 15 open reading frame 62. (175 aa)
LOC100147550Uncharacterized protein. (235 aa)
ELNUncharacterized protein. (1088 aa)
HIP1RHuntingtin interacting protein 1 related. (1203 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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