STRINGSTRING
PTPN14 PTPN14 GAS6 GAS6 PTPN2 PTPN2 PSPN PSPN TOB1 TOB1 CBL CBL SHC1 SHC1 RNF41 RNF41 SH2B3 SH2B3 ANGPT4 ANGPT4 SHC2 SHC2 GRB2 GRB2 MYOC MYOC ZPR1 ZPR1 CRK CRK PCNA PCNA ELMO2 ELMO2 TRADD TRADD CADM4 CADM4 SHC4 SHC4 ARHGEF16 ARHGEF16 ANGPT2 ANGPT2 MAP3K7 MAP3K7 ANGPT1 ANGPT1 FNTA FNTA PIK3R1 PIK3R1 TRAT1 TRAT1 GRB14 GRB14 PLCG1 PLCG1 MST1 MST1 RACK1 RACK1 DOK2 DOK2 SH2B1 SH2B1 LRP4 LRP4 PTPN11 PTPN11 PITPNM2 PITPNM2 GFRAL GFRAL PITPNM3 PITPNM3 PIK3R2 PIK3R2 PTPN1 PTPN1 LOC100050401 LOC100050401 CRKL CRKL FLT3LG FLT3LG NCK2 NCK2 DOCK4 DOCK4 ALKAL1 ALKAL1 CBLB CBLB NRTN NRTN DAZAP2 DAZAP2 SH2B2 SH2B2 ALKAL2 ALKAL2 TP53 TP53 FIZ1 FIZ1 ARTN ARTN GAB2 GAB2 GDNF GDNF FRS2 FRS2 FRS3 FRS3 PITPNM1 PITPNM1 CPNE3 CPNE3 SHC3 SHC3 STAP1 STAP1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PTPN14Protein tyrosine phosphatase non-receptor type 14. (1190 aa)
GAS6Growth arrest specific 6. (646 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
PSPNPersephin. (153 aa)
TOB1Transducer of ERBB2, 1. (600 aa)
CBLCbl proto-oncogene. (914 aa)
SHC1SHC adaptor protein 1. (584 aa)
RNF41Ring finger protein 41. (317 aa)
SH2B3SH2B adaptor protein 3. (561 aa)
ANGPT4Angiopoietin 4. (497 aa)
SHC2SHC adaptor protein 2. (579 aa)
GRB2Growth factor receptor bound protein 2. (217 aa)
MYOCMyocilin. (490 aa)
ZPR1ZPR1 zinc finger. (459 aa)
CRKCRK proto-oncogene, adaptor protein. (304 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
ELMO2Engulfment and cell motility 2. (732 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
CADM4Cell adhesion molecule 4. (388 aa)
SHC4SHC adaptor protein 4. (630 aa)
ARHGEF16Rho guanine nucleotide exchange factor 16. (749 aa)
ANGPT2Angiopoietin 2. (496 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
ANGPT1Angiopoietin 1. (498 aa)
FNTAFarnesyltransferase, CAAX box, alpha. (379 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
TRAT1T cell receptor associated transmembrane adaptor 1. (187 aa)
GRB14Growth factor receptor bound protein 14. (540 aa)
PLCG11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase gamma; Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. (1291 aa)
MST1Macrophage stimulating 1; Belongs to the peptidase S1 family. Plasminogen subfamily. (725 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
DOK2Docking protein 2. (521 aa)
SH2B1SH2B adaptor protein 1. (757 aa)
LRP4LDL receptor related protein 4. (1905 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PITPNM2Phosphatidylinositol transfer protein membrane associated 2. (1331 aa)
GFRALGDNF family receptor alpha like. (402 aa)
PITPNM3PITPNM family member 3. (973 aa)
PIK3R2Uncharacterized protein. (479 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (493 aa)
LOC100050401SH2 domain-containing protein. (266 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FLT3LGFms related tyrosine kinase 3 ligand. (241 aa)
NCK2Cytoplasmic protein. (380 aa)
DOCK4Dedicator of cytokinesis 4; Belongs to the DOCK family. (1974 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
CBLBCbl proto-oncogene B. (1189 aa)
NRTNNeurturin. (197 aa)
DAZAP2DAZ associated protein 2. (170 aa)
SH2B2SH2B adaptor protein 2. (873 aa)
ALKAL2Uncharacterized protein. (576 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
FIZ1FLT3 interacting zinc finger 1. (496 aa)
ARTNArtemin. (228 aa)
GAB2GRB2 associated binding protein 2. (708 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
FRS3Fibroblast growth factor receptor substrate 3. (545 aa)
PITPNM1Phosphatidylinositol transfer protein membrane associated 1. (1352 aa)
CPNE3Copine 3. (533 aa)
SHC3SHC adaptor protein 3. (591 aa)
STAP1Signal transducing adaptor family member 1. (297 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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