STRINGSTRING
RYBP RYBP PABPN1L PABPN1L TRAF3IP2 TRAF3IP2 HMOX1 HMOX1 CAMLG CAMLG MYD88 MYD88 LOC100068208 LOC100068208 LOC100068320 LOC100068320 TOB1 TOB1 RBM10 RBM10 CTSA CTSA EHMT2 EHMT2 SCFD1 SCFD1 PML PML BAG5 BAG5 ATP2B4 ATP2B4 RNF41 RNF41 TTC36 TTC36 TRAF5 TRAF5 USP9X USP9X HNRNPU HNRNPU TARDBP TARDBP PTPN3 PTPN3 HSP90AB1 HSP90AB1 F6RGJ5_HORSE F6RGJ5_HORSE WNT1 WNT1 IL10 IL10 PINK1 PINK1 HIPK2 HIPK2 IGF2BP1 IGF2BP1 SGTA SGTA A1CF A1CF GIPC2 GIPC2 LRRK2 LRRK2 DAZL DAZL F6SJC9_HORSE F6SJC9_HORSE TENT2 TENT2 PBK PBK TRAF2 TRAF2 VIP VIP TMEM39B TMEM39B SMG1 SMG1 MFSD2A MFSD2A SEC22B SEC22B TENT5A TENT5A BAG6 BAG6 TIMP1 TIMP1 CSNK2A2 CSNK2A2 LEPR LEPR NUPR1 NUPR1 LOC100061588 LOC100061588 IL10RA IL10RA MT3 MT3 TREM2 TREM2 PKP1 PKP1 KLHL22 KLHL22 DAPL1 DAPL1 DHX9 DHX9 SMCR8 SMCR8 NSUN2 NSUN2 MEIOC MEIOC CHMP4A CHMP4A IGF2BP3 IGF2BP3 QSOX1 QSOX1 PARK7 PARK7 C13H16orf96 C13H16orf96 NBAS NBAS UBXN1 UBXN1 TIMP3 TIMP3 AXIN2 AXIN2 HNRNPAB HNRNPAB BECN1 BECN1 KDM4A KDM4A KLHL40 KLHL40 TENT5B TENT5B LRIG2 LRIG2 TIGAR TIGAR ELAVL1 ELAVL1 HTR2B HTR2B TENT5C TENT5C SUFU SUFU LZTS1 LZTS1 DDRGK1 DDRGK1 DFFB DFFB TMEM39A TMEM39A RASIP1 RASIP1 THRAP3 THRAP3 TSPO TSPO TLK2 TLK2 MAPKAPK2 MAPKAPK2 BMF BMF CPTP CPTP USP14 USP14 YBX1 YBX1 DKC1 DKC1 LRPPRC LRPPRC E2F1 E2F1 WDR6 WDR6 OGT OGT N4BP1 N4BP1 INS INS HFE HFE DHX36 DHX36 PKP3 PKP3 FOXK2 FOXK2 NRDE2 NRDE2 PDCL3 PDCL3 TRDMT1 TRDMT1 IKBKE IKBKE BOLL BOLL CSDE1 CSDE1 RPL11 RPL11 LARP1 LARP1 FEZ1 FEZ1 LOC100069257 LOC100069257 FEZ2 FEZ2 EIF4ENIF1 EIF4ENIF1 LOC100055965 LOC100055965 ENSECAP00000027490 ENSECAP00000027490 ENSECAP00000027703 ENSECAP00000027703 SYNCRIP SYNCRIP DHX34 DHX34 DAP DAP ENSECAP00000029811 ENSECAP00000029811 SORL1 SORL1 SIRT2 SIRT2 RUBCN RUBCN SVIP SVIP MTM1 MTM1 FUS FUS TRIM75P TRIM75P TP53 TP53 WAC WAC PHAX PHAX NOCT NOCT ENSECAP00000034220 ENSECAP00000034220 PHF23 PHF23 RBM38 RBM38 STYX STYX SLC11A1 SLC11A1 LEP LEP MTMR8 MTMR8 STAT3 STAT3 USP7 USP7 APOBEC1 APOBEC1 GDNF GDNF BCL2 BCL2 POLDIP2 POLDIP2 RBM24 RBM24 PARN PARN ENSECAP00000039198 ENSECAP00000039198 APOC3 APOC3 ZCCHC17 ZCCHC17 GPLD1 GPLD1 GIPC3 GIPC3 PABPC1 PABPC1 ANGEL2 ANGEL2 EIF3H EIF3H UBQLN4 UBQLN4 TIMP4 TIMP4 GIPC1 GIPC1 PLIN5 PLIN5 LOC111772418 LOC111772418 ZFP36 ZFP36 IGF2BP2 IGF2BP2 FMR1 FMR1 TBC1D14 TBC1D14 CCAR2 CCAR2 CLEC16A CLEC16A TIMP2 TIMP2 MTOR MTOR MTMR9 MTMR9 NOP53 NOP53 RBM46 RBM46 ELAVL4 ELAVL4 FHIT FHIT SECISBP2 SECISBP2 UCHL5 UCHL5 CSPG5 CSPG5 ETFBKMT ETFBKMT RNF5 RNF5
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RYBPRING1 and YY1 binding protein. (228 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (271 aa)
TRAF3IP2TRAF3 interacting protein 2. (578 aa)
HMOX1Heme oxygenase 1. (490 aa)
CAMLGCalcium signal-modulating cyclophilin ligand; Likely involved in the mobilization of calcium as a result of the TCR/CD3 complex interaction. Binds to cyclophilin B. (296 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
LOC100068208Uncharacterized protein. (470 aa)
LOC100068320Uncharacterized protein. (470 aa)
TOB1Transducer of ERBB2, 1. (600 aa)
RBM10RNA binding motif protein 10. (931 aa)
CTSACarboxypeptidase; Belongs to the peptidase S10 family. (494 aa)
EHMT2Euchromatic histone lysine methyltransferase 2. (1389 aa)
SCFD1Sec1 family domain containing 1; Belongs to the STXBP/unc-18/SEC1 family. (641 aa)
PMLPromyelocytic leukemia. (881 aa)
BAG5BAG family molecular chaperone regulator-like protein. (447 aa)
ATP2B4Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1206 aa)
RNF41Ring finger protein 41. (317 aa)
TTC36Tetratricopeptide repeat domain 36. (188 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
USP9XUbiquitin specific peptidase 9 X-linked; Belongs to the peptidase C19 family. (2570 aa)
HNRNPUHeterogeneous nuclear ribonucleoprotein U. (825 aa)
TARDBPTAR DNA-binding protein 43-like protein. (414 aa)
PTPN3Tyrosine-protein phosphatase non-receptor type; May act at junctions between the membrane and the cytoskeleton. (913 aa)
HSP90AB1Heat shock protein HSP 90-beta; Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co- chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Engages with a range of client protein classes via its interact [...] (730 aa)
F6RGJ5_HORSEUncharacterized protein. (127 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
PINK1PTEN induced kinase 1. (585 aa)
HIPK2Homeodomain interacting protein kinase 2. (1244 aa)
IGF2BP1Insulin like growth factor 2 mRNA binding protein 1. (577 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
A1CFAPOBEC1 complementation factor. (597 aa)
GIPC2GIPC PDZ domain containing family member 2. (314 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
DAZLDeleted in azoospermia like. (295 aa)
F6SJC9_HORSEIg-like domain-containing protein. (324 aa)
TENT2Terminal nucleotidyltransferase 2. (484 aa)
PBKPDZ binding kinase. (405 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
VIPVasoactive intestinal peptide. (171 aa)
TMEM39BTransmembrane protein 39B. (492 aa)
SMG1SMG1 nonsense mediated mRNA decay associated PI3K related kinase; Belongs to the PI3/PI4-kinase family. (3660 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (529 aa)
SEC22BSEC22 homolog B, vesicle trafficking protein; Belongs to the synaptobrevin family. (239 aa)
TENT5ATerminal nucleotidyltransferase 5A. (453 aa)
BAG6BCL2 associated athanogene 6. (1073 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
CSNK2A2Casein kinase 2 alpha 2; Belongs to the protein kinase superfamily. (350 aa)
LEPRLeptin receptor. (1165 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
LOC100061588Uncharacterized protein. (472 aa)
IL10RAInterleukin 10 receptor subunit alpha. (572 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
PKP1Plakophilin 1. (903 aa)
KLHL22Kelch like family member 22. (634 aa)
DAPL1Death associated protein like 1. (101 aa)
DHX9DExH-box helicase 9. (1284 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
NSUN2NOP2/Sun RNA methyltransferase 2; Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. (759 aa)
MEIOCMeiosis specific with coiled-coil domain. (1036 aa)
CHMP4ACharged multivesicular body protein 4A. (264 aa)
IGF2BP3Insulin like growth factor 2 mRNA binding protein 3. (579 aa)
QSOX1Sulfhydryl oxidase. (752 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
C13H16orf96Chromosome 13 C16orf96 homolog. (1102 aa)
NBASNeuroblastoma amplified sequence. (2374 aa)
UBXN1UBX domain protein 1. (295 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. (211 aa)
AXIN2Axin 2. (843 aa)
HNRNPABUncharacterized protein. (333 aa)
BECN1Beclin 1. (448 aa)
KDM4ALysine demethylase 4A. (1065 aa)
KLHL40Kelch like family member 40. (622 aa)
TENT5BTerminal nucleotidyltransferase 5B. (427 aa)
LRIG2Leucine rich repeats and immunoglobulin like domains 2. (1023 aa)
TIGARTP53 induced glycolysis regulatory phosphatase. (298 aa)
ELAVL1ELAV-like protein; Belongs to the RRM elav family. (326 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
TENT5CTerminal nucleotidyltransferase 5C. (391 aa)
SUFUSUFU negative regulator of hedgehog signaling. (566 aa)
LZTS1Leucine zipper tumor suppressor 1. (600 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
DFFBDNA fragmentation factor subunit beta. (340 aa)
TMEM39ATransmembrane protein 39A. (488 aa)
RASIP1Ras interacting protein 1. (964 aa)
THRAP3Thyroid hormone receptor associated protein 3. (958 aa)
TSPOTranslocator protein. (308 aa)
TLK2Tousled like kinase 2. (750 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
BMFBcl2 modifying factor. (227 aa)
CPTPCeramide-1-phosphate transfer protein. (214 aa)
USP14Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (554 aa)
YBX1Y-box binding protein 1. (324 aa)
DKC1Dyskerin pseudouridine synthase 1. (520 aa)
LRPPRCLeucine rich pentatricopeptide repeat containing. (1394 aa)
E2F1E2F transcription factor 1. (436 aa)
WDR6WD repeat domain 6. (1186 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
N4BP1NEDD4 binding protein 1. (897 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (361 aa)
DHX36DEAH-box helicase 36. (1029 aa)
PKP3Plakophilin 3. (807 aa)
FOXK2Forkhead box K2. (655 aa)
NRDE2NRDE-2, necessary for RNA interference, domain containing. (1165 aa)
PDCL3Phosducin-like protein 3-like protein. (241 aa)
TRDMT1tRNA aspartic acid methyltransferase 1; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. (529 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
BOLLBoule homolog, RNA binding protein. (295 aa)
CSDE1Cold shock domain containing E1. (820 aa)
RPL11Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (178 aa)
LARP1La ribonucleoprotein domain family member 1. (1387 aa)
FEZ1Fasciculation and elongation protein zeta 1. (408 aa)
LOC100069257NTR domain-containing protein. (281 aa)
FEZ2Fasciculation and elongation protein zeta 2. (383 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
LOC100055965Myotubularin phosphatase domain-containing protein. (739 aa)
ENSECAP00000027490Uncharacterized protein. (461 aa)
ENSECAP00000027703NTR domain-containing protein. (197 aa)
SYNCRIPSynaptotagmin binding cytoplasmic RNA interacting protein. (623 aa)
DHX34DExH-box helicase 34. (1147 aa)
DAPUncharacterized protein. (250 aa)
ENSECAP00000029811Uncharacterized protein. (281 aa)
SORL1Sortilin related receptor 1. (2255 aa)
SIRT2Sirtuin 2. (462 aa)
RUBCNRubicon autophagy regulator. (1013 aa)
SVIPUncharacterized protein. (225 aa)
MTM1Myotubularin 1. (636 aa)
FUSUncharacterized protein. (519 aa)
TRIM75PTripartite motif containing 75, pseudogene. (426 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
WACWW domain containing adaptor with coiled-coil. (1112 aa)
PHAXPhosphorylated adaptor for RNA export. (394 aa)
NOCTNocturnin. (431 aa)
ENSECAP00000034220CSD_1 domain-containing protein. (289 aa)
PHF23PHD finger protein 23. (403 aa)
RBM38RNA binding motif protein 38. (281 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
SLC11A1Solute carrier family 11 member 1. (648 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
MTMR8Myotubularin related protein 8. (926 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
USP7Ubiquitin specific peptidase 7; Belongs to the peptidase C19 family. (1140 aa)
APOBEC1Apolipoprotein B mRNA editing enzyme catalytic subunit 1. (236 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
BCL2BCL2 apoptosis regulator. (285 aa)
POLDIP2DNA polymerase delta interacting protein 2. (559 aa)
RBM24RNA binding motif protein 24. (236 aa)
PARNPoly(A)-specific ribonuclease. (646 aa)
ENSECAP00000039198CSP domain-containing protein. (364 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (117 aa)
ZCCHC17Zinc finger CCHC-type containing 17. (241 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
GIPC3GIPC PDZ domain containing family member 3. (312 aa)
PABPC1Uncharacterized protein. (648 aa)
ANGEL2Angel homolog 2. (544 aa)
EIF3HEukaryotic translation initiation factor 3 subunit H; Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF- 2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribos [...] (391 aa)
UBQLN4Ubiquilin 4. (615 aa)
TIMP4TIMP metallopeptidase inhibitor 4. (237 aa)
GIPC1GIPC PDZ domain containing family member 1. (332 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
LOC111772418Ribosomal protein L11; Belongs to the universal ribosomal protein uL5 family. (180 aa)
ZFP36Uncharacterized protein. (662 aa)
IGF2BP2Insulin like growth factor 2 mRNA binding protein 2. (1029 aa)
FMR1Fragile X mental retardation 1. (632 aa)
TBC1D14TBC1 domain family member 14. (693 aa)
CCAR2Cell cycle and apoptosis regulator 2. (1019 aa)
CLEC16AC-type lectin domain containing 16A. (1048 aa)
TIMP2Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them. (343 aa)
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
MTMR9Myotubularin related protein 9. (550 aa)
NOP53NOP53 ribosome biogenesis factor. (549 aa)
RBM46RNA binding motif protein 46. (532 aa)
ELAVL4ELAV-like protein; Belongs to the RRM elav family. (402 aa)
FHITBis(5'-adenosyl)-triphosphatase. (149 aa)
SECISBP2SECIS binding protein 2. (878 aa)
UCHL5Ubiquitin carboxyl-terminal hydrolase. (329 aa)
CSPG5SWI/SNF related, matrix associated, actin dependent regulator of chromatin subfamily c member 1. (1681 aa)
ETFBKMTElectron transfer flavoprotein subunit beta lysine methyltransferase. (299 aa)
RNF5Ring finger protein 5. (241 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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