STRINGSTRING
FOXO3 FOXO3 INS INS RAD23A RAD23A DCP1A DCP1A EXOSC9 EXOSC9 GSK3B GSK3B TNRC6A TNRC6A DHX36 DHX36 PACSIN3 PACSIN3 PTK2B PTK2B PTPN1 PTPN1 SH3GLB1 SH3GLB1 TRIM6 TRIM6 CNOT2 CNOT2 CBFA2T3 CBFA2T3 ATF6 ATF6 DCP1B DCP1B WIPI1 WIPI1 YTHDF1 YTHDF1 RNF180 RNF180 PLIN5 PLIN5 NPRL3 NPRL3 CNOT3 CNOT3 ZFP36 ZFP36 CDK16 CDK16 ENSECAP00000045503 ENSECAP00000045503 PLEKHF1 PLEKHF1 PATL1 PATL1 PIP4K2A PIP4K2A SESN1 SESN1 DET1 DET1 ENSECAP00000047374 ENSECAP00000047374 AADAC AADAC RC3H1 RC3H1 ABCD1 ABCD1 HIF1A HIF1A RNF14 RNF14 RB1CC1 RB1CC1 SAMD4B SAMD4B BCAP31 BCAP31 DNAJB2 DNAJB2 SH3D19 SH3D19 NOP53 NOP53 NKD2 NKD2 DAPK1 DAPK1 TNFRSF1B TNFRSF1B ATG13 ATG13 FBXW9 FBXW9 ZBTB20 ZBTB20 CALCOCO2 CALCOCO2 PRKN PRKN TRIB1 TRIB1 PRXL2C PRXL2C PABPN1L PABPN1L TRIB3 TRIB3 LRRC27 LRRC27 HMOX1 HMOX1 TNF TNF FOXO1 FOXO1 TOB1 TOB1 FAM122A FAM122A NANOS1 NANOS1 SESN2 SESN2 ADRA2A ADRA2A SOCS4 SOCS4 LOC100147364 LOC100147364 BAG3 BAG3 PDE12 PDE12 CNOT7 CNOT7 NANOS2 NANOS2 RNF152 RNF152 LOC100054534 LOC100054534 TRIM21 TRIM21 FBXO22 FBXO22 EXOSC7 EXOSC7 MEFV MEFV PRAF2 PRAF2 CLU CLU TRIM67 TRIM67 AGO2 AGO2 ZSWIM8 ZSWIM8 RNF19A RNF19A OPTN OPTN TRIM68 TRIM68 IL4 IL4 TARDBP TARDBP HMGB1 HMGB1 CNOT6 CNOT6 SH3RF3 SH3RF3 ATG101 ATG101 PRICKLE1 PRICKLE1 ZFP36L1 ZFP36L1 BECN1 BECN1 RAB3GAP2 RAB3GAP2 AXIN2 AXIN2 LRSAM1 LRSAM1 PLK1 PLK1 SESN3 SESN3 SMURF1 SMURF1 ZFP36L2 ZFP36L2 TP53INP1 TP53INP1 BNIP3 BNIP3 NOD2 NOD2 BTG2 BTG2 TPCN1 TPCN1 VPS13D VPS13D CDC20B CDC20B TRIM8 TRIM8 ITCH ITCH ULK1 ULK1 IL6 IL6 SUPV3L1 SUPV3L1 RCHY1 RCHY1 SMCR8 SMCR8 NANOS3 NANOS3 TRIM34 TRIM34 SNX33 SNX33 DEPDC5 DEPDC5 USP5 USP5 STK11 STK11 MAPK3 MAPK3 RALB RALB F7CNV6_HORSE F7CNV6_HORSE DXO DXO GSK3A GSK3A AKT3 AKT3 CDC20 CDC20 PAN2 PAN2 PRR5L PRR5L KDR KDR DCN DCN DDRGK1 DDRGK1 ZYG11A ZYG11A SMAD7 SMAD7 PNPT1 PNPT1 TRIM71 TRIM71 PSMD10 PSMD10 TRIM65 TRIM65 DVL1 DVL1 TBK1 TBK1 POLR2G POLR2G SH3RF1 SH3RF1 PUM1 PUM1 METTL14 METTL14 MLXIPL MLXIPL ROCK1 ROCK1 LOC100055155 LOC100055155 APP APP TSC2 TSC2 CLUL1 CLUL1 NRDC NRDC PIP4K2B PIP4K2B RACK1 RACK1 NPRL2 NPRL2 PRKAA1 PRKAA1 FBXW7 FBXW7 GBA GBA PLEKHN1 PLEKHN1 YTHDF2 YTHDF2 AXIN1 AXIN1 AADAC-2 AADAC-2 EXOSC5 EXOSC5 GIGYF2 GIGYF2 TRIM38 TRIM38 SH3RF2 SH3RF2 TFEB TFEB GRSF1 GRSF1 SPTLC2 SPTLC2 DISC1 DISC1 CCDC22 CCDC22 NOD1 NOD1 NUB1 NUB1 TRIM27 TRIM27 MEX3D MEX3D PAFAH1B2 PAFAH1B2 PABPC1 PABPC1 CNOT6L CNOT6L RAB3GAP1 RAB3GAP1 CAV1 CAV1 ENSECAP00000040460 ENSECAP00000040460 AGBL4 AGBL4 ABHD5 ABHD5 SH3BP4 SH3BP4 GPLD1 GPLD1 RIDA RIDA GPD1 GPD1 LIN28B LIN28B PARN PARN DCP2 DCP2 ADAM8 ADAM8 DIS3L2 DIS3L2 PIP4K2C PIP4K2C SAMD4A SAMD4A ATG16L1 ATG16L1 FZR1 FZR1 C23H9orf72 C23H9orf72 RC3H2 RC3H2 MKRN2 MKRN2 ENSECAP00000036553 ENSECAP00000036553 ZYG11B ZYG11B SNX4 SNX4 FBXW8 FBXW8 SUPT5H SUPT5H ZER1 ZER1 MAPK9 MAPK9 PIAS1 PIAS1 DAB2 DAB2 CPEB3 CPEB3 AKT1 AKT1 LOC100146242 LOC100146242 NOCT NOCT IGF1 IGF1 RIPK2 RIPK2 TMEM59 TMEM59 WAC WAC TNRC6B TNRC6B HTR2A HTR2A AMBRA1 AMBRA1 LOC100070407 LOC100070407 EXOSC2 EXOSC2 GTPBP1 GTPBP1 AGTPBP1 AGTPBP1 SVIP SVIP SIRT6 SIRT6 EXOSC3 EXOSC3 IFNG IFNG RNF217 RNF217 SPTLC1 SPTLC1 RNF144A RNF144A SIRT1 SIRT1 SIRT2 SIRT2 SCOC SCOC UFL1 UFL1 BBS7 BBS7 MTDH MTDH ARIH1 ARIH1 SNX7 SNX7 KAT5 KAT5 COP1 COP1 ZC3HAV1 ZC3HAV1 EIF4ENIF1 EIF4ENIF1 PRKD1 PRKD1 LARP1 LARP1 STING1 STING1 FLCN FLCN PAN3 PAN3 RNF144B RNF144B SNX9 SNX9 SNX18 SNX18 ATG2A ATG2A CCDC90B CCDC90B FYCO1 FYCO1 PATL2 PATL2 CNOT8 CNOT8 DAGLB DAGLB PRKAA2 PRKAA2 TTC5 TTC5 DCPS DCPS PNLDC1 PNLDC1 JMJD8 JMJD8 EXOSC8 EXOSC8 TNRC6C TNRC6C TRIML2 TRIML2 PNPLA2 PNPLA2 RNF19B RNF19B MID2 MID2 ZC3H18 ZC3H18 BTNL9 BTNL9 TRIML1 TRIML1 DDA1 DDA1 SNX30 SNX30 HERPUD1 HERPUD1 TRIM13 TRIM13 RUFY4 RUFY4 ARIH2 ARIH2 TP53INP2 TP53INP2 YTHDF3 YTHDF3 UPF1 UPF1 CNOT1 CNOT1 LRRK2 LRRK2 ANKIB1 ANKIB1 CCNY CCNY LSM1 LSM1 P2RX7 P2RX7 TRIB2 TRIB2 SGTA SGTA CSNK1D CSNK1D INSR INSR HTT HTT ENDOG ENDOG DTX3L DTX3L FBXO7 FBXO7 ZC3H12A ZC3H12A PINK1 PINK1 TRIM32 TRIM32 AKT2 AKT2 RNF139 RNF139 F6WH02_HORSE F6WH02_HORSE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
FOXO3Forkhead box O3. (671 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
DCP1ADecapping mRNA 1A. (580 aa)
EXOSC9Exosome component 9. (440 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
TNRC6ATrinucleotide repeat containing adaptor 6A. (1951 aa)
DHX36DEAH-box helicase 36. (1029 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (428 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (493 aa)
SH3GLB1SH3 domain containing GRB2 like, endophilin B1. (402 aa)
TRIM6Uncharacterized protein. (490 aa)
CNOT2CCR4-NOT transcription complex subunit 2. (844 aa)
CBFA2T3CBFA2/RUNX1 translocation partner 3. (658 aa)
ATF6Activating transcription factor 6. (669 aa)
DCP1BDecapping mRNA 1B. (620 aa)
WIPI1WD repeat domain, phosphoinositide interacting 1. (456 aa)
YTHDF1YTH N6-methyladenosine RNA binding protein 1. (624 aa)
RNF180Ring finger protein 180. (592 aa)
PLIN5Perilipin; Belongs to the perilipin family. (457 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (664 aa)
CNOT3CCR4-NOT transcription complex subunit 3. (779 aa)
ZFP36Uncharacterized protein. (662 aa)
CDK16Cyclin dependent kinase 16. (573 aa)
ENSECAP00000045503Endo/exonuclease/phosphatase domain-containing protein. (538 aa)
PLEKHF1Pleckstrin homology and FYVE domain containing 1. (330 aa)
PATL1PAT1 homolog 1, processing body mRNA decay factor. (874 aa)
PIP4K2APhosphatidylinositol-5-phosphate 4-kinase type 2 alpha. (587 aa)
SESN1Sestrin 1. (551 aa)
DET1DET1 partner of COP1 E3 ubiquitin ligase. (709 aa)
ENSECAP00000047374Uncharacterized protein. (56 aa)
AADACArylacetamide deacetylase. (399 aa)
RC3H1Ring finger and CCCH-type domains 1. (1131 aa)
ABCD1ATP binding cassette subfamily D member 1. (732 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
RNF14RBR-type E3 ubiquitin transferase. (467 aa)
RB1CC1RB1 inducible coiled-coil 1. (1637 aa)
SAMD4BSterile alpha motif domain containing 4B. (786 aa)
BCAP31B cell receptor associated protein 31. (280 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (325 aa)
SH3D19SH3 domain containing 19. (1072 aa)
NOP53NOP53 ribosome biogenesis factor. (549 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (553 aa)
DAPK1Death associated protein kinase 1. (1457 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
ATG13Autophagy-related protein 13; Belongs to the ATG13 family. Metazoan subfamily. (550 aa)
FBXW9F-box and WD repeat domain containing 9. (477 aa)
ZBTB20Zinc finger and BTB domain containing 20. (757 aa)
CALCOCO2Calcium binding and coiled-coil domain 2. (502 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
TRIB1Tribbles pseudokinase 1. (386 aa)
PRXL2CPeroxiredoxin like 2C. (226 aa)
PABPN1LPoly(A) binding protein nuclear 1 like, cytoplasmic. (271 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
LRRC27Leucine rich repeat containing 27. (521 aa)
HMOX1Heme oxygenase 1. (490 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
FOXO1Forkhead box O1. (651 aa)
TOB1Transducer of ERBB2, 1. (600 aa)
FAM122AFamily with sequence similarity 122A. (329 aa)
NANOS1Nanos C2HC-type zinc finger 1; Belongs to the nanos family. (289 aa)
SESN2Sestrin 2. (481 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
LOC100147364Ribonuclease UK114-like protein. (137 aa)
BAG3BCL2 associated athanogene 3. (582 aa)
PDE12Phosphodiesterase 12. (609 aa)
CNOT7CCR4-NOT transcription complex subunit 7. (285 aa)
NANOS2Nanos C2HC-type zinc finger 2; Belongs to the nanos family. (138 aa)
RNF152Ring finger protein 152. (203 aa)
LOC100054534Uncharacterized protein. (511 aa)
TRIM21Tripartite motif containing 21. (469 aa)
FBXO22FIST_C domain-containing protein. (404 aa)
EXOSC7Exosome component 7. (321 aa)
MEFVMEFV innate immuity regulator, pyrin. (117 aa)
PRAF2WD repeat domain 45. (361 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (450 aa)
TRIM67Tripartite motif containing 67. (783 aa)
AGO2Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)
ZSWIM8Zinc finger SWIM-type containing 8. (1842 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
OPTNOptineurin. (574 aa)
TRIM68Tripartite motif containing 68. (484 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
TARDBPTAR DNA-binding protein 43-like protein. (414 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
CNOT6CCR4-NOT transcription complex subunit 6. (557 aa)
SH3RF3SH3 domain containing ring finger 3. (879 aa)
ATG101Autophagy related 101. (218 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
BECN1Beclin 1. (448 aa)
RAB3GAP2Uncharacterized protein. (1393 aa)
AXIN2Axin 2. (843 aa)
LRSAM1Leucine rich repeat and sterile alpha motif containing 1. (727 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
SESN3Sestrin 3. (488 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
ZFP36L2ZFP36 ring finger protein like 2. (510 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
BNIP3BCL2 interacting protein 3. (243 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
BTG2BTG anti-proliferation factor 2. (150 aa)
TPCN1Two pore segment channel 1. (818 aa)
VPS13DVacuolar protein sorting 13 homolog D. (4388 aa)
CDC20BCell division cycle 20B. (515 aa)
TRIM8Tripartite motif containing 8. (551 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1059 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
SUPV3L1Suv3 like RNA helicase. (786 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
SMCR8SMCR8-C9orf72 complex subunit. (937 aa)
NANOS3Nanos C2HC-type zinc finger 3; Belongs to the nanos family. (176 aa)
TRIM34Uncharacterized protein. (496 aa)
SNX33Sorting nexin. (574 aa)
DEPDC5DEP domain containing 5. (1602 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
RALBRAS like proto-oncogene B. (206 aa)
F7CNV6_HORSEUncharacterized protein. (1071 aa)
DXODecapping exoribonuclease. (397 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
AKT3Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (479 aa)
CDC20Cell division cycle 20. (499 aa)
PAN2PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa)
PRR5LProline rich 5 like. (368 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
DCNDecorin; May affect the rate of fibrils formation; Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily. (360 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
ZYG11AZyg-11 family member A, cell cycle regulator. (760 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PNPT1Polyribonucleotide nucleotidyltransferase 1. (801 aa)
TRIM71Tripartite motif containing 71. (868 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (270 aa)
TRIM65Tripartite motif containing 65. (517 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
TBK1TANK binding kinase 1. (729 aa)
POLR2GRNA polymerase II subunit G. (172 aa)
SH3RF1SH3 domain containing ring finger 1. (886 aa)
PUM1Pumilio RNA binding family member 1. (1223 aa)
METTL14Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
MLXIPLMLX interacting protein like. (905 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
LOC100055155Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
APPAmyloid beta precursor protein. (811 aa)
TSC2TSC complex subunit 2. (1817 aa)
CLUL1Clusterin; Belongs to the clusterin family. (465 aa)
NRDCNardilysin convertase. (1247 aa)
PIP4K2BPhosphatidylinositol-5-phosphate 4-kinase type 2 beta. (439 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
NPRL2NPR2 like, GATOR1 complex subunit. (380 aa)
PRKAA1Non-specific serine/threonine protein kinase. (633 aa)
FBXW7F-box and WD repeat domain containing 7. (754 aa)
GBAGlucosylceramidase. (536 aa)
PLEKHN1Pleckstrin homology domain containing N1. (612 aa)
YTHDF2YTH N6-methyladenosine RNA binding protein 2. (580 aa)
AXIN1Axin 1. (939 aa)
AADAC-2Arylacetamide deacetylase. (278 aa)
EXOSC5Exosome component 5. (235 aa)
GIGYF2GRB10 interacting GYF protein 2. (1284 aa)
TRIM38Tripartite motif containing 38. (464 aa)
SH3RF2SH3 domain containing ring finger 2. (732 aa)
TFEBTranscription factor EB. (522 aa)
GRSF1G-rich RNA sequence binding factor 1. (654 aa)
SPTLC2Serine palmitoyltransferase long chain base subunit 2. (597 aa)
DISC1DISC1 scaffold protein. (890 aa)
CCDC22Coiled-coil domain containing 22. (627 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (640 aa)
TRIM27Tripartite motif containing 27. (536 aa)
MEX3DMex-3 RNA binding family member D. (917 aa)
PAFAH1B2Platelet-activating factor acetylhydrolase I subunit beta-like protein. (229 aa)
PABPC1Uncharacterized protein. (648 aa)
CNOT6LCCR4-NOT transcription complex subunit 6 like. (562 aa)
RAB3GAP1RAB3 GTPase activating protein catalytic subunit 1. (989 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
ENSECAP00000040460Uncharacterized protein. (104 aa)
AGBL4ATP/GTP binding protein like 4. (531 aa)
ABHD5Abhydrolase domain containing 5. (378 aa)
SH3BP4SH3 domain binding protein 4. (964 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
RIDAReactive intermediate imine deaminase A homolog. (137 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
LIN28BLin-28 homolog B. (258 aa)
PARNPoly(A)-specific ribonuclease. (646 aa)
DCP2Decapping mRNA 2. (422 aa)
ADAM8Uncharacterized protein. (824 aa)
DIS3L2DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (905 aa)
PIP4K2CPhosphatidylinositol-5-phosphate 4-kinase type 2 gamma. (591 aa)
SAMD4ASterile alpha motif domain containing 4A. (758 aa)
ATG16L1Autophagy related 16 like 1. (914 aa)
FZR1Fizzy and cell division cycle 20 related 1. (695 aa)
C23H9orf72Chromosome 23 C9orf72 homolog. (481 aa)
RC3H2Ring finger and CCCH-type domains 2. (1121 aa)
MKRN2Makorin ring finger protein 2. (502 aa)
ENSECAP00000036553Uncharacterized protein. (46 aa)
ZYG11BZyg-11 family member B, cell cycle regulator. (760 aa)
SNX4Sorting nexin 4. (475 aa)
FBXW8F-box and WD repeat domain containing 8. (851 aa)
SUPT5HTranscription elongation factor SPT5. (1087 aa)
ZER1Zyg-11 related cell cycle regulator. (766 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
PIAS1Protein inhibitor of activated STAT 1. (678 aa)
DAB2DAB adaptor protein 2. (765 aa)
CPEB3Cytoplasmic polyadenylation element binding protein 3. (731 aa)
AKT1Non-specific serine/threonine protein kinase; Belongs to the protein kinase superfamily. (496 aa)
LOC100146242ABC transmembrane type-1 domain-containing protein. (379 aa)
NOCTNocturnin. (431 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
TMEM59Transmembrane protein 59. (378 aa)
WACWW domain containing adaptor with coiled-coil. (1112 aa)
TNRC6BTrinucleotide repeat containing adaptor 6B. (1872 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
AMBRA1Autophagy and beclin 1 regulator 1. (1299 aa)
LOC100070407ABC transporter domain-containing protein. (230 aa)
EXOSC2Exosome component 2. (342 aa)
GTPBP1GTP binding protein 1. (669 aa)
AGTPBP1ATP/GTP binding protein 1. (1278 aa)
SVIPUncharacterized protein. (225 aa)
SIRT6Sirtuin 6. (407 aa)
EXOSC3Exosome component 3. (275 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
RNF217RBR-type E3 ubiquitin transferase. (540 aa)
SPTLC1Serine palmitoyltransferase long chain base subunit 1. (474 aa)
RNF144ARBR-type E3 ubiquitin transferase. (361 aa)
SIRT1Sirtuin 1. (737 aa)
SIRT2Sirtuin 2. (462 aa)
SCOCShort coiled-coil protein. (193 aa)
UFL1UFM1 specific ligase 1. (791 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
MTDHMetadherin. (615 aa)
ARIH1RBR-type E3 ubiquitin transferase. (554 aa)
SNX7Sorting nexin 7. (471 aa)
KAT5Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa)
COP1COP1 E3 ubiquitin ligase. (737 aa)
ZC3HAV1Zinc finger CCCH-type containing, antiviral 1. (1021 aa)
EIF4ENIF1Eukaryotic translation initiation factor 4E nuclear import factor 1. (985 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
LARP1La ribonucleoprotein domain family member 1. (1387 aa)
STING1Transmembrane protein 173. (405 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (829 aa)
PAN3PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (921 aa)
RNF144BRBR-type E3 ubiquitin transferase. (304 aa)
SNX9Sorting nexin. (621 aa)
SNX18Sorting nexin. (624 aa)
ATG2AAutophagy related 2A. (1935 aa)
CCDC90BCoiled-coil domain containing 90B. (267 aa)
FYCO1FYVE and coiled-coil domain containing 1. (1478 aa)
PATL2PAT1 homolog 2. (542 aa)
CNOT8CCR4-NOT transcription complex subunit 8. (292 aa)
DAGLBDiacylglycerol lipase beta. (672 aa)
PRKAA2Non-specific serine/threonine protein kinase. (552 aa)
TTC5Tetratricopeptide repeat domain 5. (458 aa)
DCPSDecapping enzyme, scavenger. (337 aa)
PNLDC1PARN like, ribonuclease domain containing 1. (531 aa)
JMJD8WD repeat domain 24. (1023 aa)
EXOSC8Exosome component 8. (276 aa)
TNRC6CTrinucleotide repeat containing adaptor 6C. (1917 aa)
TRIML2Tripartite motif family like 2. (427 aa)
PNPLA2Patatin like phospholipase domain containing 2. (491 aa)
RNF19BRBR-type E3 ubiquitin transferase. (549 aa)
MID2Midline 2. (735 aa)
ZC3H18Zinc finger CCCH-type containing 18. (972 aa)
BTNL9Butyrophilin like 9. (545 aa)
TRIML1Tripartite motif family like 1. (462 aa)
DDA1DET1 and DDB1 associated 1. (102 aa)
SNX30Sorting nexin family member 30. (459 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (392 aa)
TRIM13Tripartite motif containing 13. (409 aa)
RUFY4RUN and FYVE domain containing 4. (572 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
TP53INP2Tumor protein p53 inducible nuclear protein 2. (221 aa)
YTHDF3YTH N6-methyladenosine RNA binding protein 3. (588 aa)
UPF1UPF1 RNA helicase and ATPase. (1127 aa)
CNOT1CCR4-NOT transcription complex subunit 1. (2376 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1103 aa)
CCNYCyclin Y; Belongs to the cyclin family. (341 aa)
LSM1U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
HTTHuntingtin. (3126 aa)
ENDOGEndonuclease. (299 aa)
DTX3LDeltex E3 ubiquitin ligase 3L. (739 aa)
FBXO7F-box protein 7. (550 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
PINK1PTEN induced kinase 1. (585 aa)
TRIM32Tripartite motif containing 32. (653 aa)
AKT2Non-specific serine/threonine protein kinase. (528 aa)
RNF139Ring finger protein 139. (665 aa)
F6WH02_HORSEFIST_C domain-containing protein. (381 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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