STRINGSTRING
LRRC8A LRRC8A CFTR CFTR PPP3CB PPP3CB TRH TRH GPR68 GPR68 PRKCE PRKCE GPER1 GPER1 PDX1 PDX1 MPC2 MPC2 TUNAR TUNAR BAD BAD AACS AACS NLGN2 NLGN2 TM7SF3 TM7SF3 NR1H4 NR1H4 BLK BLK C2CD2L C2CD2L RFX6 RFX6 ADCY8 ADCY8 GHRL GHRL SOX4 SOX4 TCF7L2 TCF7L2 DOC2B DOC2B ANO1 ANO1 RPH3AL RPH3AL PLA2G6 PLA2G6 GCK GCK GPLD1 GPLD1 NNAT NNAT MCU MCU CAPN10 CAPN10 SRI SRI HIF1A HIF1A C1QTNF12 C1QTNF12
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRC8ALeucine rich repeat containing 8 VRAC subunit A. (810 aa)
CFTRCystic fibrosis transmembrane conductance regulator; Epithelial ion channel that plays an important role in the regulation of epithelial ion and water transport and fluid homeostasis. Mediates the transport of chloride ions across the cell membrane (By similarity). Channel activity is coupled to ATP hydrolysis. The ion channel is also permeable to HCO(3-); selectivity depends on the extracellular chloride concentration. Exerts its function also by modulating the activity of other ion channels and transporters. Contributes to the regulation of the pH and the ion content of the epithelia [...] (1541 aa)
PPP3CBSerine/threonine-protein phosphatase. (525 aa)
TRHPro-thyrotropin-releasing hormone; Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems. (245 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (389 aa)
PRKCEProtein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
PDX1Pancreatic and duodenal homeobox 1. (282 aa)
MPC2Mitochondrial pyruvate carrier; Mediates the uptake of pyruvate into mitochondria. Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family. (189 aa)
TUNARTCL1 upstream neural differentiation-associated RNA. (48 aa)
BADBCL2 associated agonist of cell death. (167 aa)
AACSAcetoacetyl-CoA synthetase. (672 aa)
NLGN2Neuroligin 2. (835 aa)
TM7SF3Transmembrane 7 superfamily member 3. (570 aa)
NR1H4Nuclear receptor subfamily 1 group H member 4. (486 aa)
BLKTyrosine-protein kinase. (500 aa)
C2CD2LC2CD2 like. (707 aa)
RFX6Regulatory factor X6. (928 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
GHRLGhrelin and obestatin prepropeptide. (117 aa)
SOX4SRY-box transcription factor 4. (496 aa)
TCF7L2Transcription factor 7 like 2. (669 aa)
DOC2BDouble C2 domain beta. (431 aa)
ANO1Anoctamin. (1215 aa)
RPH3ALRabphilin 3A like (without C2 domains). (316 aa)
PLA2G6Phospholipase A2 group VI. (1134 aa)
GCKPhosphotransferase. (496 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
NNATNeuronatin. (54 aa)
MCUMitochondrial calcium uniporter. (356 aa)
CAPN10Calpain 10; Belongs to the peptidase C2 family. (781 aa)
SRISorcin. (216 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
C1QTNF12C1q and TNF related 12. (300 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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