STRINGSTRING
GAS6 GAS6 ADRA2A ADRA2A ADRA2B ADRA2B INSR INSR MT3 MT3 FGF1 FGF1 ITGB1BP1 ITGB1BP1 INS INS PDGFB PDGFB OSBPL8 OSBPL8 LOC106780934 LOC106780934 IGF1 IGF1 ADRA2C ADRA2C NTRK3 NTRK3 DYNAP DYNAP IL18 IL18 ENSECAP00000041942 ENSECAP00000041942 PDPK1 PDPK1 RNASE4 RNASE4
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
GAS6Growth arrest specific 6. (646 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
ADRA2BAlpha-2B adrenergic receptor; Alpha-2 adrenergic receptors mediate the catecholamine- induced inhibition of adenylate cyclase through the action of G proteins. (549 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
OSBPL8Oxysterol-binding protein; Belongs to the OSBP family. (927 aa)
LOC106780934Chromosome 8 C18orf54 homolog. (494 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
ADRA2CAdrenoceptor alpha 2C. (458 aa)
NTRK3Tyrosine-protein kinase receptor. (863 aa)
DYNAPCLLAC domain-containing protein. (277 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSECAP00000041942CLLAC domain-containing protein. (160 aa)
PDPK13-phosphoinositide dependent protein kinase 1. (585 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (156 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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