(28 nodes) Positive regulation of interleukin-2 production network (Equus caballus)

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second shell of interactors

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Predicted Interactions

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Your Input:
	RUNX1	RUNX family transcription factor 1. (537 aa)
	CARD11	Caspase recruitment domain family member 11. (1156 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	GLMN	Glomulin, FKBP associated protein. (597 aa)
	BTNL2	Butyrophilin like 2. (560 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	MALT1	MALT1 paracaspase. (850 aa)
	RPS3	Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
	STOML2	Stomatin like 2. (356 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	IL1A	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa)
	PRKD2	Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
	IRF4	Interferon regulatory factor 4. (606 aa)
	ABL1	Tyrosine-protein kinase. (1149 aa)
	PLCG2	Phosphoinositide phospholipase C. (1331 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
	STAT5B	Signal transducer and activator of transcription. (825 aa)
	CD83	CD83 molecule. (330 aa)
	VTCN1	V-set domain containing T cell activation inhibitor 1. (282 aa)
	PTPRC	Protein tyrosine phosphatase receptor type C. (1399 aa)
	STAT5A	Signal transducer and activator of transcription. (800 aa)
	CD28	CD28 molecule. (228 aa)
	PDE4B	Phosphodiesterase. (736 aa)
	ENSECAP00000051121	KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
	MAP3K7	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
	PDE4D	Phosphodiesterase. (808 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ABL1	RUNX1	ENSECAP00000031551	ENSECAP00000003260	Tyrosine-protein kinase.	RUNX family transcription factor 1.	0.620
ABL1	STAT5A	ENSECAP00000031551	ENSECAP00000039763	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.922
ABL1	STAT5B	ENSECAP00000031551	ENSECAP00000035292	Tyrosine-protein kinase.	Signal transducer and activator of transcription.	0.927
CARD11	MALT1	ENSECAP00000004938	ENSECAP00000011434	Caspase recruitment domain family member 11.	MALT1 paracaspase.	0.989
CARD11	MAP3K7	ENSECAP00000004938	ENSECAP00000051563	Caspase recruitment domain family member 11.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.711
CARD11	PRKCQ	ENSECAP00000004938	ENSECAP00000035268	Caspase recruitment domain family member 11.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.993
CARD11	RIPK2	ENSECAP00000004938	ENSECAP00000033250	Caspase recruitment domain family member 11.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.549
CARD11	TRAF6	ENSECAP00000004938	ENSECAP00000018618	Caspase recruitment domain family member 11.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.711
CD28	PRKCQ	ENSECAP00000047018	ENSECAP00000035268	CD28 molecule.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.950
CD28	VTCN1	ENSECAP00000047018	ENSECAP00000037737	CD28 molecule.	V-set domain containing T cell activation inhibitor 1.	0.436
IL1A	TRAF6	ENSECAP00000021137	ENSECAP00000018618	Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.744
IRF4	TRAF6	ENSECAP00000027192	ENSECAP00000018618	Interferon regulatory factor 4.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.528
MALT1	CARD11	ENSECAP00000011434	ENSECAP00000004938	MALT1 paracaspase.	Caspase recruitment domain family member 11.	0.989
MALT1	MAP3K7	ENSECAP00000011434	ENSECAP00000051563	MALT1 paracaspase.	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	0.641
MALT1	PRKCQ	ENSECAP00000011434	ENSECAP00000035268	MALT1 paracaspase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.648
MALT1	RIPK2	ENSECAP00000011434	ENSECAP00000033250	MALT1 paracaspase.	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains.	0.419
MALT1	TRAF2	ENSECAP00000011434	ENSECAP00000011150	MALT1 paracaspase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.406
MALT1	TRAF6	ENSECAP00000011434	ENSECAP00000018618	MALT1 paracaspase.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.911
MAP3K7	CARD11	ENSECAP00000051563	ENSECAP00000004938	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	Caspase recruitment domain family member 11.	0.711
MAP3K7	MALT1	ENSECAP00000051563	ENSECAP00000011434	Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.	MALT1 paracaspase.	0.641