STRINGSTRING
RIPK2 RIPK2 FADD FADD MMP1 MMP1 APP APP MAPKAPK2 MAPKAPK2 DDX58 DDX58 IL23A IL23A ARID5A ARID5A ARFGEF2 ARFGEF2 PTPN11 PTPN11 ILT11A ILT11A ENSECAP00000026226 ENSECAP00000026226 TMEM106A TMEM106A LOC111772122 LOC111772122 PLCG2 PLCG2 TLR3 TLR3 LEP LEP STAT3 STAT3 SYK SYK PTPRC PTPRC IL17A IL17A AZU1 AZU1 CD14 CD14 NOD1 NOD1 ENSECAP00000042736 ENSECAP00000042736 SETD4 SETD4 MAVS MAVS C1QTNF4 C1QTNF4 ZBTB20 ZBTB20 AGER AGER HSPB1 HSPB1 CD84 CD84 PIK3R1 PIK3R1 CD2 CD2 CARD9 CARD9 LOC100054272 LOC100054272 LY96 LY96 NOD2 NOD2 IL6 IL6 DHX9 DHX9 HAVCR2 HAVCR2 ARHGEF2 ARHGEF2 TLR9 TLR9 TNFRSF8 TNFRSF8 LOC111770212 LOC111770212 IL12B IL12B TIRAP TIRAP NFATC4 NFATC4 LRRK2 LRRK2 CYBA CYBA RASGRP1 RASGRP1 SASH3 SASH3 RIPK1 RIPK1 PYCARD PYCARD THBS1 THBS1 IFIH1 IFIH1 HMGB1 HMGB1 SPHK2 SPHK2 FRMD8 FRMD8 MYD88 MYD88 LOC111767791 LOC111767791
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
MMP1Interstitial collagenase. (520 aa)
APPAmyloid beta precursor protein. (811 aa)
MAPKAPK2MAPK activated protein kinase 2; Belongs to the protein kinase superfamily. (400 aa)
DDX58DExD/H-box helicase 58. (1021 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa)
ARID5AAT-rich interaction domain 5A. (601 aa)
ARFGEF2ADP ribosylation factor guanine nucleotide exchange factor 2. (1779 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
ILT11AIg-like domain-containing protein. (302 aa)
ENSECAP00000026226Ig-like domain-containing protein. (298 aa)
TMEM106ATransmembrane protein 106A. (261 aa)
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
SYKTyrosine-protein kinase. (716 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
IL17AUncharacterized protein. (155 aa)
AZU1Azurocidin 1. (251 aa)
CD14CD14 molecule. (369 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
ENSECAP00000042736Ig-like domain-containing protein. (274 aa)
SETD4SET domain containing 4. (511 aa)
MAVSMitochondrial antiviral signaling protein. (597 aa)
C1QTNF4C1q domain-containing protein. (98 aa)
ZBTB20Zinc finger and BTB domain containing 20. (757 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
HSPB1Heat shock protein family B (small) member 1; Belongs to the small heat shock protein (HSP20) family. (209 aa)
CD84CD84 molecule. (343 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
CD2T-cell surface antigen CD2; CD2 interacts with lymphocyte function-associated antigen CD58 (LFA-3) to mediate adhesion between T-cells and other cell types. CD2 is implicated in the triggering of T-cells, the cytoplasmic domain is implicated in the signaling function. (347 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
LOC100054272Ig-like domain-containing protein. (270 aa)
LY96Lymphocyte antigen 96. (173 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
DHX9DExH-box helicase 9. (1284 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1176 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
TNFRSF8TNF receptor superfamily member 8. (605 aa)
LOC111770212C-C motif chemokine. (100 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
TIRAPTIR domain containing adaptor protein. (234 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
CYBACytochrome b-245 light chain; Critical component of the membrane-bound oxidase of phagocytes that generates superoxide. Associates with NOX3 to form a functional NADPH oxidase constitutively generating superoxide. (194 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PYCARDPYD and CARD domain containing. (195 aa)
THBS1Thrombospondin 1. (1170 aa)
IFIH1Interferon induced with helicase C domain 1. (1026 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
SPHK2Sphingosine kinase 2. (654 aa)
FRMD8FERM domain containing 8. (462 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
LOC111767791CD14 molecule. (376 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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