(17 nodes) Negative regulation of GTPase activity network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

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textmining

co-expression

protein homology

Your Input:
	KLRK1	Killer cell lectin like receptor K1. (232 aa)
	ARL2	ARL2-SNX15 readthrough (NMD candidate); Belongs to the small GTPase superfamily. Arf family. (184 aa)
	BBS4	Bardet-Biedl syndrome 4. (531 aa)
	F11R	F11 receptor. (307 aa)
	TTC8	Tetratricopeptide repeat domain 8. (515 aa)
	AMOT	Angiomotin. (1089 aa)
	GMIP	GEM interacting protein. (959 aa)
	DAB2IP	DAB2 interacting protein. (1166 aa)
	LRCH1	Leucine rich repeats and calponin homology domain containing 1. (763 aa)
	MKKS	McKusick-Kaufman syndrome. (570 aa)
	FZD10	Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	RCC2	Regulator of chromosome condensation 2. (561 aa)
	SH3BP4	SH3 domain binding protein 4. (964 aa)
	LRRK2	Leucine rich repeat kinase 2. (2528 aa)
	SPRY1	Sprouty RTK signaling antagonist 1. (366 aa)
	ARFGEF1	ADP ribosylation factor guanine nucleotide exchange factor 1. (1849 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BBS4	TTC8	ENSECAP00000024106	ENSECAP00000035699	Bardet-Biedl syndrome 4.	Tetratricopeptide repeat domain 8.	0.999
LRCH1	SH3BP4	ENSECAP00000048686	ENSECAP00000039870	Leucine rich repeats and calponin homology domain containing 1.	SH3 domain binding protein 4.	0.477
SH3BP4	LRCH1	ENSECAP00000039870	ENSECAP00000048686	SH3 domain binding protein 4.	Leucine rich repeats and calponin homology domain containing 1.	0.477
SPRY1	SPRY2	ENSECAP00000011420	ENSECAP00000001560	Sprouty RTK signaling antagonist 1.	Sprouty RTK signaling antagonist 2.	0.560
SPRY2	SPRY1	ENSECAP00000001560	ENSECAP00000011420	Sprouty RTK signaling antagonist 2.	Sprouty RTK signaling antagonist 1.	0.560
TTC8	BBS4	ENSECAP00000035699	ENSECAP00000024106	Tetratricopeptide repeat domain 8.	Bardet-Biedl syndrome 4.	0.999