STRINGSTRING
RIPK1 RIPK1 SMPD3 SMPD3 TCL1A TCL1A F7DNA3_HORSE F7DNA3_HORSE TRAF3IP2 TRAF3IP2 GPER1 GPER1 NKX3-1 NKX3-1 MYOD1 MYOD1 TNF TNF KRT18-2 KRT18-2 ADIPOQ ADIPOQ CASP8 CASP8 ERBIN ERBIN NR1D1 NR1D1 CCL20 CCL20 ADAM9 ADAM9 LRRC7 LRRC7 TRAF5 TRAF5 CARD14 CARD14 ADAMTS7 ADAMTS7 SLC2A4 SLC2A4 ADAM10 ADAM10 TRIM32 TRIM32 ZC3H12A ZC3H12A TMEM130 TMEM130 ENDOG ENDOG PYCARD PYCARD OCSTAMP OCSTAMP BAG4 BAG4 PID1 PID1 SMPD1 SMPD1 LOC111770212 LOC111770212 TRAF2 TRAF2 TRADD TRADD FAS FAS YBX3 YBX3 RPS3 RPS3 RELA RELA LOC100063059 LOC100063059 ARHGEF2 ARHGEF2 MAPK3 MAPK3 GCH1 GCH1 CDIP1 CDIP1 CXCL8 CXCL8 DHX9 DHX9 ADAMTS12 ADAMTS12 TNFSF11 TNFSF11 INPP5K INPP5K CD70 CD70 CD40 CD40 TNFRSF21 TNFRSF21 HYAL2 HYAL2 ZFP36L2 ZFP36L2 PIAS3 PIAS3 HYAL3 HYAL3 CRHBP CRHBP ZFAND6 ZFAND6 CIB1 CIB1 LOC100060619 LOC100060619 CXCL16 CXCL16 ZFP36L1 ZFP36L1 DCSTAMP DCSTAMP TNFSF13B TNFSF13B TNFRSF4 TNFRSF4 CCL25 CCL25 TNFRSF17 TNFRSF17 TNFRSF18 TNFRSF18 TRAF6 TRAF6 HAS2 HAS2 GSDME GSDME SFRP1 SFRP1 PLVAP PLVAP CCL26 CCL26 GBA GBA EXT1 EXT1 NFKBIA NFKBIA CCL8 CCL8 CCL2 CCL2 CASP10 CASP10 CD58 CD58 FOXO3 FOXO3 LOC100630171 LOC100630171 F6PYR5_HORSE F6PYR5_HORSE CCL14 CCL14 CCL5 CCL5 PTK2B PTK2B LOC111767408 LOC111767408 GATA3 GATA3 TANK TANK DAB2IP DAB2IP TNFSF18 TNFSF18 SMPD4 SMPD4 MAP4K3 MAP4K3 CCL24 CCL24 ENSECAP00000028450 ENSECAP00000028450 ILK ILK LOC111772209 LOC111772209 CCL16 CCL16 SIRT1 SIRT1 IKBKB IKBKB ANKRD1 ANKRD1 LOC111772122 LOC111772122 STAT1 STAT1 ENSECAP00000032524 ENSECAP00000032524 FABP4 FABP4 TP53 TP53 CCL17 CCL17 CCL13 CCL13 CCL1 CCL1 COMMD7 COMMD7 ENSECAP00000036712 ENSECAP00000036712 CHUK CHUK CX3CL1 CX3CL1 AIM2 AIM2 CACTIN CACTIN GPD1 GPD1 CHI3L1 CHI3L1 TNFRSF13C TNFRSF13C ENSECAP00000040755 ENSECAP00000040755 UBD UBD CD14 CD14 NUB1 NUB1 KRT18 KRT18 CCL22 CCL22 YTHDC2 YTHDC2 ACTN4 ACTN4 TRAF3 TRAF3 SPHK1 SPHK1 ZFP36 ZFP36 TRAF1 TRAF1 XCL1 XCL1 RORA RORA TXNDC17 TXNDC17 CCL4 CCL4 CCL3 CCL3 CCL11 CCL11 MAPK1 MAPK1 ENSECAP00000051121 ENSECAP00000051121 NFE2L2 NFE2L2 TNFRSF11A TNFRSF11A TNFRSF1B TNFRSF1B CLDN18 CLDN18 TNFRSF1A TNFRSF1A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
TCL1AT cell leukemia/lymphoma 1A. (115 aa)
F7DNA3_HORSEIF rod domain-containing protein; Belongs to the intermediate filament family. (428 aa)
TRAF3IP2TRAF3 interacting protein 2. (578 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
NKX3-1NK3 homeobox 1. (240 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
KRT18-2IF rod domain-containing protein; Belongs to the intermediate filament family. (438 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
ERBINErbb2 interacting protein. (1461 aa)
NR1D1Nuclear receptor subfamily 1 group D member 1. (605 aa)
CCL20C-C motif chemokine. (96 aa)
ADAM9ADAM metallopeptidase domain 9. (819 aa)
LRRC7Leucine rich repeat containing 7. (1575 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
CARD14Caspase recruitment domain family member 14. (1003 aa)
ADAMTS7ADAM metallopeptidase with thrombospondin type 1 motif 7. (1686 aa)
SLC2A4Solute carrier family 2 member 4; Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. (509 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
TRIM32Tripartite motif containing 32. (653 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
TMEM130Transmembrane protein 130. (435 aa)
ENDOGEndonuclease. (299 aa)
PYCARDPYD and CARD domain containing. (195 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (505 aa)
BAG4BCL2 associated athanogene 4. (456 aa)
PID1Phosphotyrosine interaction domain containing 1. (336 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (824 aa)
LOC111770212C-C motif chemokine. (100 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
FASFas cell surface death receptor. (365 aa)
YBX3Y-box binding protein 3. (360 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
LOC100063059SCY domain-containing protein. (131 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1176 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
GCH1GTP cyclohydrolase 1. (415 aa)
CDIP1Cell death inducing p53 target 1. (208 aa)
CXCL8Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
DHX9DExH-box helicase 9. (1284 aa)
ADAMTS12ADAM metallopeptidase with thrombospondin type 1 motif 12. (1598 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (318 aa)
INPP5KInositol polyphosphate-5-phosphatase K. (449 aa)
CD70Tumor necrosis factor ligand 8A; Belongs to the tumor necrosis factor family. (198 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
TNFRSF21TNF receptor superfamily member 21. (659 aa)
HYAL2Hyaluronidase. (710 aa)
ZFP36L2ZFP36 ring finger protein like 2. (510 aa)
PIAS3Protein inhibitor of activated STAT 3. (629 aa)
HYAL3Hyaluronidase. (415 aa)
CRHBPCorticotropin-releasing factor-binding protein; Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy. Belongs to the CRF-binding protein family. (321 aa)
ZFAND6Zinc finger AN1-type containing 6. (208 aa)
CIB1Calcium and integrin binding 1. (191 aa)
LOC100060619SCY domain-containing protein. (124 aa)
CXCL16C-X-C motif chemokine ligand 16. (247 aa)
ZFP36L1ZFP36 ring finger protein like 1. (338 aa)
DCSTAMPDendrocyte expressed seven transmembrane protein. (470 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
TNFRSF4TNF receptor superfamily member 4. (320 aa)
CCL25C-C motif chemokine ligand 25. (151 aa)
TNFRSF17TNF receptor superfamily member 17. (181 aa)
TNFRSF18TNF receptor superfamily member 18. (169 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
HAS2Hyaluronan synthase 2. (552 aa)
GSDMEGasdermin-E, C-terminal; Plays a role in the TP53-regulated cellular response to DNA damage probably by cooperating with TP53. (497 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PLVAPPlasmalemma vesicle associated protein. (438 aa)
CCL26C-C motif chemokine. (94 aa)
GBAGlucosylceramidase. (536 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
NFKBIANFKB inhibitor alpha. (543 aa)
CCL8SCY domain-containing protein. (99 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (478 aa)
CD58CD58 molecule. (244 aa)
FOXO3Forkhead box O3. (671 aa)
LOC100630171C-C motif chemokine. (140 aa)
F6PYR5_HORSEC-C motif chemokine. (121 aa)
CCL14C-C motif chemokine. (95 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
LOC111767408Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
GATA3GATA binding protein 3. (445 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
TNFSF18Tumor necrosis factor ligand 2A. (178 aa)
SMPD4Sphingomyelin phosphodiesterase 4. (939 aa)
MAP4K3Mitogen-activated protein kinase kinase kinase kinase 3; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (894 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
ENSECAP00000028450SCY domain-containing protein. (96 aa)
ILKIntegrin linked kinase. (452 aa)
LOC111772209Claudin-18. (261 aa)
CCL16C-C motif chemokine. (164 aa)
SIRT1Sirtuin 1. (737 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
ANKRD1Ankyrin repeat domain 1. (381 aa)
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
STAT1Signal transducer and activator of transcription. (749 aa)
ENSECAP00000032524Uncharacterized protein. (85 aa)
FABP4Fatty acid binding protein 4; Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. (183 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
CCL17C-C motif chemokine. (198 aa)
CCL13SCY domain-containing protein. (264 aa)
CCL1SCY domain-containing protein. (94 aa)
COMMD7COMM domain containing 7. (200 aa)
ENSECAP00000036712Uncharacterized protein. (63 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
CX3CL1SCY domain-containing protein. (561 aa)
AIM2Absent in melanoma 2. (352 aa)
CACTINCactin, spliceosome C complex subunit. (753 aa)
GPD1Glycerol-3-phosphate dehydrogenase [NAD(+)]. (349 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (427 aa)
TNFRSF13CB cell-activating factor receptor. (183 aa)
ENSECAP00000040755WAP domain-containing protein. (67 aa)
UBDUbiquitin D. (171 aa)
CD14CD14 molecule. (369 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (640 aa)
KRT18IF rod domain-containing protein; Belongs to the intermediate filament family. (430 aa)
CCL22C-C motif chemokine ligand 22. (98 aa)
YTHDC2YTH domain containing 2. (1434 aa)
ACTN4Actinin alpha 4. (933 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
SPHK1Sphingosine kinase 1. (459 aa)
ZFP36Uncharacterized protein. (662 aa)
TRAF1TNF receptor-associated factor. (415 aa)
XCL1SCY domain-containing protein. (206 aa)
RORARAR related orphan receptor A. (527 aa)
TXNDC17Thioredoxin domain containing 17. (159 aa)
CCL4SCY domain-containing protein. (97 aa)
CCL3SCY domain-containing protein. (226 aa)
CCL11Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. (102 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
TNFRSF11ATNF receptor superfamily member 11a. (647 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
CLDN18Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (261 aa)
TNFRSF1ATNF receptor superfamily member 1A. (475 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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