STRINGSTRING
NET1 NET1 PLEKHA1 PLEKHA1 MAPK3 MAPK3 FOS FOS RELA RELA RPS3 RPS3 MAPK7 MAPK7 ADPRHL2 ADPRHL2 RNF112 RNF112 ROMO1 ROMO1 SRC SRC SOD2 SOD2 EDN1 EDN1 PRDX2 PRDX2 RIPK1 RIPK1 KDM6B KDM6B TNFAIP3 TNFAIP3 PRDX1 PRDX1 RIPK3 RIPK3 PCGF2 PCGF2 PJVK PJVK FANCC FANCC F6W654_HORSE F6W654_HORSE TRPA1 TRPA1 SMPD3 SMPD3 PTPRK PTPRK NFE2L2 NFE2L2 ENSECAP00000051121 ENSECAP00000051121 ENSECAP00000050619 ENSECAP00000050619 AQP1 AQP1 TREX1 TREX1 MAPK1 MAPK1 PDGFRA PDGFRA SPHK1 SPHK1 CAT CAT SOD3 SOD3 SOD1 SOD1 ENSECAP00000041588 ENSECAP00000041588 MAPK13 MAPK13 ECT2 ECT2 MAP3K5 MAP3K5 ENSECAP00000038121 ENSECAP00000038121 HDAC6 HDAC6 CHUK CHUK EGFR EGFR MAPK9 MAPK9 ENSECAP00000034428 ENSECAP00000034428 SETX SETX ABL1 ABL1 SIRT1 SIRT1 IMPACT IMPACT ZNF580 ZNF580 NOS3 NOS3 JUN JUN TRPM2 TRPM2 PDK2 PDK2 CCS CCS EZH2 EZH2 NQO1 NQO1 ZNF277 ZNF277 PPARGC1B PPARGC1B SIGMAR1 SIGMAR1 CYP1B1 CYP1B1 FXN FXN OSER1 OSER1 PDCD10 PDCD10 STK25 STK25 PRDX5 PRDX5 PRDX3 PRDX3 PARK7 PARK7 IL6 IL6 ANKZF1 ANKZF1 ANXA1 ANXA1 NCF1 NCF1 MT3 MT3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
NET1Neuroepithelial cell transforming 1. (596 aa)
PLEKHA1Pleckstrin homology domain containing A1. (438 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
MAPK7Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (811 aa)
ADPRHL2ADP-ribosylhydrolase like 2. (365 aa)
RNF112Ring finger protein 112. (629 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
SRCTyrosine-protein kinase. (551 aa)
SOD2Superoxide dismutase [Mn], mitochondrial; Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (222 aa)
EDN1Endothelin 1. (202 aa)
PRDX2Peroxiredoxin 2. (198 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
KDM6BLysine demethylase 6B. (1636 aa)
TNFAIP3TNF alpha induced protein 3. (794 aa)
PRDX1Peroxiredoxin 1. (199 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (513 aa)
PCGF2Polycomb group ring finger 2. (344 aa)
PJVKPejvakin. (352 aa)
FANCCFA complementation group C. (623 aa)
F6W654_HORSESuperoxide dismutase; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the iron/manganese superoxide dismutase family. (216 aa)
TRPA1Transient receptor potential cation channel subfamily A member 1; Belongs to the transient receptor (TC 1.A.4) family. (1120 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1485 aa)
NFE2L2Nuclear factor, erythroid 2 like 2. (605 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
ENSECAP00000050619Thioredoxin domain-containing protein. (199 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SPHK1Sphingosine kinase 1. (459 aa)
CATCatalase. (598 aa)
SOD3Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems. Belongs to the Cu-Zn superoxide dismutase family. (296 aa)
SOD1Superoxide dismutase [Cu-Zn]; Destroys radicals which are normally produced within the cells and which are toxic to biological systems; Belongs to the Cu-Zn superoxide dismutase family. (171 aa)
ENSECAP00000041588Uncharacterized protein. (152 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
ECT2Epithelial cell transforming 2. (1042 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
ENSECAP00000038121Redoxin domain-containing protein. (157 aa)
HDAC6Histone deacetylase 6. (1266 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
ENSECAP00000034428Uncharacterized protein. (97 aa)
SETXSenataxin. (2680 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
SIRT1Sirtuin 1. (737 aa)
IMPACTImpact RWD domain protein. (359 aa)
ZNF580Zinc finger protein 580. (172 aa)
NOS3Nitric oxide synthase; Produces nitric oxide (NO). (1267 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
TRPM2Transient receptor potential cation channel subfamily M member 2. (1524 aa)
PDK2Protein-serine/threonine kinase. (407 aa)
CCSCopper chaperone for superoxide dismutase. (274 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
NQO1NAD(P)H quinone dehydrogenase 1. (274 aa)
ZNF277Zinc finger protein 277. (456 aa)
PPARGC1BPPARG coactivator 1 beta. (1239 aa)
SIGMAR1Sigma non-opioid intracellular receptor 1. (223 aa)
CYP1B1Cytochrome P450 family 1 subfamily B member 1; Belongs to the cytochrome P450 family. (560 aa)
FXNFrataxin. (211 aa)
OSER1Oxidative stress responsive serine rich 1. (292 aa)
PDCD10Programmed cell death 10. (212 aa)
STK25Serine/threonine kinase 25. (426 aa)
PRDX5Peroxiredoxin; Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides; Belongs to the peroxiredoxin family. Prx5 subfamily. (151 aa)
PRDX3Peroxiredoxin 3. (374 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
ANKZF1Ankyrin repeat and zinc finger domain containing 1. (723 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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