STRINGSTRING
POLK POLK STK11 STK11 NFATC4 NFATC4 PPID PPID ERCC4 ERCC4 XPA XPA SPIB SPIB NOC2L NOC2L KDM1A KDM1A TREX1 TREX1 EP300 EP300 DDB2 DDB2 SDE2 SDE2 PTPRK PTPRK ERCC1 ERCC1 AQP1 AQP1 RHBDD1 RHBDD1 METTL3 METTL3 TMEM161A TMEM161A TIMP1 TIMP1 AURKB AURKB OPN3 OPN3 SMPD1 SMPD1 PCNA PCNA RHNO1 RHNO1 MMP3 MMP3 MFAP4 MFAP4 PARP1 PARP1 NEDD4 NEDD4 TP53 TP53 SIRT1 SIRT1 CDC25A CDC25A IMPACT IMPACT CASP9 CASP9 DHX36 DHX36 CREBBP CREBBP ACTR5 ACTR5 OPN5 OPN5 POLH POLH N4BP1 N4BP1 MAPK13 MAPK13 PBK PBK POLD3 POLD3 C9orf116 C9orf116 CUL4B CUL4B BAK1 BAK1 DDB1 DDB1 PRKCD PRKCD INO80 INO80 OPN1SW OPN1SW BMF BMF CDKN1A CDKN1A USP47 USP47 PIK3R1 PIK3R1 EIF2S1 EIF2S1 HYAL3 HYAL3 ZBTB1 ZBTB1 TP53INP1 TP53INP1 HYAL2 HYAL2 RUVBL2 RUVBL2 XPC XPC
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
POLKDNA polymerase kappa. (860 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
NFATC4Nuclear factor of activated T cells 4. (932 aa)
PPIDPeptidylprolyl isomerase D. (398 aa)
ERCC4ERCC excision repair 4, endonuclease catalytic subunit. (916 aa)
XPAXPA, DNA damage recognition and repair factor. (315 aa)
SPIBDNA polymerase; Belongs to the ETS family. (1327 aa)
NOC2LNOC2 like nucleolar associated transcriptional repressor. (868 aa)
KDM1ALysine demethylase 1A. (1007 aa)
TREX1Three prime repair exonuclease 1. (314 aa)
EP300E1A binding protein p300. (2430 aa)
DDB2Damage specific DNA binding protein 2. (427 aa)
SDE2SDE2 telomere maintenance homolog. (453 aa)
PTPRKProtein tyrosine phosphatase receptor type K. (1485 aa)
ERCC1ERCC excision repair 1, endonuclease non-catalytic subunit. (311 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
RHBDD1Rhomboid domain containing 1. (316 aa)
METTL3Methyltransferase like 3; Belongs to the MT-A70-like family. (580 aa)
TMEM161ATransmembrane protein 161A. (479 aa)
TIMP1Metalloproteinase inhibitor 1; Metalloproteinase inhibitor that functions by forming one to one complexes with target metalloproteinases, such as collagenases, and irreversibly inactivates them by binding to their catalytic zinc cofactor. Acts on MMP1, MMP2, MMP3, MMP7, MMP8, MMP9, MMP10, MMP11, MMP12, MMP13 and MMP16. Does not act on MMP14. Also functions as a growth factor that regulates cell differentiation, migration and cell death and activates cellular signaling cascades via CD63 and ITGB1. Plays a role in integrin signaling (By similarity). (207 aa)
AURKBAurora kinase B; Belongs to the protein kinase superfamily. (344 aa)
OPN3Opsin 3; Belongs to the G-protein coupled receptor 1 family. (402 aa)
SMPD1Sphingomyelin phosphodiesterase 1. (824 aa)
PCNAProliferating cell nuclear antigen; This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand; Belongs to the PCNA family. (261 aa)
RHNO1RAD9-HUS1-RAD1 interacting nuclear orphan 1. (241 aa)
MMP3Stromelysin-1; Can degrade fibronectin, laminin, gelatins of type I, III, IV, and V; collagens III, IV, X, and IX, and cartilage proteoglycans. Activates procollagenase; Belongs to the peptidase M10A family. (477 aa)
MFAP4Microfibril associated protein 4. (271 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
NEDD4NEDD4 E3 ubiquitin protein ligase. (1324 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
SIRT1Sirtuin 1. (737 aa)
CDC25ACell division cycle 25A. (524 aa)
IMPACTImpact RWD domain protein. (359 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
DHX36DEAH-box helicase 36. (1029 aa)
CREBBPCREB binding protein. (2442 aa)
ACTR5Actin related protein 5; Belongs to the actin family. (613 aa)
OPN5Opsin 5; Belongs to the G-protein coupled receptor 1 family. (382 aa)
POLHDNA polymerase eta. (713 aa)
N4BP1NEDD4 binding protein 1. (897 aa)
MAPK13Mitogen-activated protein kinase. (421 aa)
PBKPDZ binding kinase. (405 aa)
POLD3DNA polymerase delta 3, accessory subunit. (465 aa)
C9orf116Chromosome 9 open reading frame 116. (136 aa)
CUL4BCullin 4B; Belongs to the cullin family. (920 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
DDB1Damage specific DNA binding protein 1. (1183 aa)
PRKCDProtein kinase C delta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti- apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (675 aa)
INO80INO80 complex ATPase subunit. (1561 aa)
OPN1SWOpsin 1, short wave sensitive. (347 aa)
BMFBcl2 modifying factor. (227 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
PIK3R1Phosphoinositide-3-kinase regulatory subunit 1. (724 aa)
EIF2S1Eukaryotic translation initiation factor subunit 1-like protein. (315 aa)
HYAL3Hyaluronidase. (415 aa)
ZBTB1Zinc finger and BTB domain containing 1. (644 aa)
TP53INP1Tumor protein p53 inducible nuclear protein 1. (239 aa)
HYAL2Hyaluronidase. (710 aa)
RUVBL2RuvB-like helicase; Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. (463 aa)
XPCXPC complex subunit, DNA damage recognition and repair factor. (943 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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