(8 nodes) CD40 receptor complex network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	TRAF5	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
	HTRA2	HtrA serine peptidase 2. (458 aa)
	TRAF2	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
	DIABLO	Diablo IAP-binding mitochondrial protein. (237 aa)
	F7CNV6_HORSE	Uncharacterized protein. (1071 aa)
	CD40	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
	TRAF3	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of proteins in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CD40	DIABLO	ENSECAP00000014907	ENSECAP00000017797	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	Diablo IAP-binding mitochondrial protein.	0.407
CD40	HTRA2	ENSECAP00000014907	ENSECAP00000000520	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	HtrA serine peptidase 2.	0.450
CD40	TRAF2	ENSECAP00000014907	ENSECAP00000011150	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.973
CD40	TRAF3	ENSECAP00000014907	ENSECAP00000043236	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.988
CD40	TRAF5	ENSECAP00000014907	ENSECAP00000005414	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.875
CD40	TRAF6	ENSECAP00000014907	ENSECAP00000018618	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.970
DIABLO	CD40	ENSECAP00000017797	ENSECAP00000014907	Diablo IAP-binding mitochondrial protein.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.407
DIABLO	F7CNV6_HORSE	ENSECAP00000017797	ENSECAP00000012056	Diablo IAP-binding mitochondrial protein.	Uncharacterized protein.	0.429
DIABLO	HTRA2	ENSECAP00000017797	ENSECAP00000000520	Diablo IAP-binding mitochondrial protein.	HtrA serine peptidase 2.	0.679
DIABLO	TRAF2	ENSECAP00000017797	ENSECAP00000011150	Diablo IAP-binding mitochondrial protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.525
DIABLO	TRAF3	ENSECAP00000017797	ENSECAP00000043236	Diablo IAP-binding mitochondrial protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.517
DIABLO	TRAF5	ENSECAP00000017797	ENSECAP00000005414	Diablo IAP-binding mitochondrial protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.458
DIABLO	TRAF6	ENSECAP00000017797	ENSECAP00000018618	Diablo IAP-binding mitochondrial protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.477
F7CNV6_HORSE	DIABLO	ENSECAP00000012056	ENSECAP00000017797	Uncharacterized protein.	Diablo IAP-binding mitochondrial protein.	0.429
F7CNV6_HORSE	TRAF2	ENSECAP00000012056	ENSECAP00000011150	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.738
F7CNV6_HORSE	TRAF3	ENSECAP00000012056	ENSECAP00000043236	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.651
F7CNV6_HORSE	TRAF5	ENSECAP00000012056	ENSECAP00000005414	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.647
F7CNV6_HORSE	TRAF6	ENSECAP00000012056	ENSECAP00000018618	Uncharacterized protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.597
HTRA2	CD40	ENSECAP00000000520	ENSECAP00000014907	HtrA serine peptidase 2.	Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity).	0.450
HTRA2	DIABLO	ENSECAP00000000520	ENSECAP00000017797	HtrA serine peptidase 2.	Diablo IAP-binding mitochondrial protein.	0.679