(54 nodes) CD4-positive, alpha-beta T cell activation network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	CBLB	Cbl proto-oncogene B. (1189 aa)
	CBLC	ANK_REP_REGION domain-containing protein. (912 aa)
	MTOR	Serine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
	TMEM98	Transmembrane protein 98. (226 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1131 aa)
	CD28	CD28 molecule. (228 aa)
	RORA	RAR related orphan receptor A. (527 aa)
	RAB44	RAB44, member RAS oncogene family. (1012 aa)
	IL2RG	Fibronectin type-III domain-containing protein. (457 aa)
	CTSL	Cathepsin L; Belongs to the peptidase C1 family. (358 aa)
	CDH26	Cadherin 26. (858 aa)
	RSAD2	Radical S-adenosyl methionine domain containing 2. (361 aa)
	LEF1	Lymphoid enhancer binding factor 1. (413 aa)
	TOX	Thymocyte selection associated high mobility group box. (526 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1121 aa)
	CD83	CD83 molecule. (330 aa)
	STAT3	Signal transducer and activator of transcription. (770 aa)
	FOXP3	Forkhead box P3. (452 aa)
	PRKCQ	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
	CRACR2A	Calcium release activated channel regulator 2A. (728 aa)
	IL18R1	Interleukin 18 receptor 1. (826 aa)
	RIPK2	Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
	SLAMF6	SLAM family member 6. (361 aa)
	BRAF	B-Raf proto-oncogene, serine/threonine kinase. (793 aa)
	CTSV	Cathepsin V; Belongs to the peptidase C1 family. (394 aa)
	IRF4	Interferon regulatory factor 4. (606 aa)
	GATA3	GATA binding protein 3. (445 aa)
	IL6R	Interleukin 6 receptor. (471 aa)
	GPR183	G-protein coupled receptor 183-like protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
	NDFIP1	Nedd4 family interacting protein 1. (221 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (709 aa)
	ENTPD7	Ectonucleoside triphosphate diphosphohydrolase 7; Belongs to the GDA1/CD39 NTPase family. (604 aa)
	TBX21	T-box transcription factor 21. (535 aa)
	STOML2	Stomatin like 2. (356 aa)
	PAX1	Paired box 1. (453 aa)
	ITCH	E3 ubiquitin-protein ligase. (862 aa)
	FUT7	Fucosyltransferase 7. (367 aa)
	IL6	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)
	IL21	Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
	NKG7	Natural killer cell granule protein 7. (167 aa)
	IL12B	Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
	PTGER4	Prostaglandin E receptor 4; Belongs to the G-protein coupled receptor 1 family. (490 aa)
	TCIRG1	V-type proton ATPase subunit a; Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. (830 aa)
	SASH3	SAM and SH3 domain containing 3. (380 aa)
	ARMC5	Armadillo repeat containing 5. (940 aa)
	STAT6	Signal transducer and activator of transcription. (847 aa)
	SEMA4A	Semaphorin 4A; Belongs to the semaphorin family. (797 aa)
	HMGB1	High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
	CARD11	Caspase recruitment domain family member 11. (1156 aa)
	BCL6	BCL6 transcription repressor. (699 aa)
	HLX	H2.0 like homeobox. (487 aa)
	NKX2-3	NK2 homeobox 3. (370 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	BCL6	ENSECAP00000013962	ENSECAP00000004014	Basic leucine zipper ATF-like transcription factor.	BCL6 transcription repressor.	0.641
BATF	FOXP3	ENSECAP00000013962	ENSECAP00000035296	Basic leucine zipper ATF-like transcription factor.	Forkhead box P3.	0.571
BATF	GATA3	ENSECAP00000013962	ENSECAP00000024082	Basic leucine zipper ATF-like transcription factor.	GATA binding protein 3.	0.600
BATF	IRF4	ENSECAP00000013962	ENSECAP00000027192	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.830
BATF	STAT3	ENSECAP00000013962	ENSECAP00000036035	Basic leucine zipper ATF-like transcription factor.	Signal transducer and activator of transcription.	0.637
BATF	TBX21	ENSECAP00000013962	ENSECAP00000015685	Basic leucine zipper ATF-like transcription factor.	T-box transcription factor 21.	0.498
BCL6	BATF	ENSECAP00000004014	ENSECAP00000013962	BCL6 transcription repressor.	Basic leucine zipper ATF-like transcription factor.	0.641
BCL6	FOXP3	ENSECAP00000004014	ENSECAP00000035296	BCL6 transcription repressor.	Forkhead box P3.	0.892
BCL6	GATA3	ENSECAP00000004014	ENSECAP00000024082	BCL6 transcription repressor.	GATA binding protein 3.	0.649
BCL6	GPR183	ENSECAP00000004014	ENSECAP00000020878	BCL6 transcription repressor.	G-protein coupled receptor 183-like protein; Belongs to the G-protein coupled receptor 1 family.	0.472
BCL6	IL21	ENSECAP00000004014	ENSECAP00000013179	BCL6 transcription repressor.	Interleukin; Belongs to the IL-15/IL-21 family.	0.629
BCL6	IL4	ENSECAP00000004014	ENSECAP00000006431	BCL6 transcription repressor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.836
BCL6	IL6	ENSECAP00000004014	ENSECAP00000014219	BCL6 transcription repressor.	Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...]	0.581
BCL6	IRF4	ENSECAP00000004014	ENSECAP00000027192	BCL6 transcription repressor.	Interferon regulatory factor 4.	0.965
BCL6	SLAMF6	ENSECAP00000004014	ENSECAP00000031501	BCL6 transcription repressor.	SLAM family member 6.	0.478
BCL6	STAT3	ENSECAP00000004014	ENSECAP00000036035	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.642
BCL6	STAT6	ENSECAP00000004014	ENSECAP00000007114	BCL6 transcription repressor.	Signal transducer and activator of transcription.	0.474
BCL6	TBX21	ENSECAP00000004014	ENSECAP00000015685	BCL6 transcription repressor.	T-box transcription factor 21.	0.700
BRAF	PRKCQ	ENSECAP00000029059	ENSECAP00000035268	B-Raf proto-oncogene, serine/threonine kinase.	Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.	0.699
BRAF	STAT3	ENSECAP00000029059	ENSECAP00000036035	B-Raf proto-oncogene, serine/threonine kinase.	Signal transducer and activator of transcription.	0.697