STRINGSTRING
MRE11 MRE11 PHF1 PHF1 TIMELESS TIMELESS RNF168 RNF168 HELB HELB RPA3 RPA3 PRPF19 PRPF19 NABP2 NABP2 WRAP53 WRAP53 INIP INIP TP53BP1 TP53BP1 PAXX PAXX SAMHD1 SAMHD1 RNF169 RNF169 RAD50 RAD50 F7AQP3_HORSE F7AQP3_HORSE LMNA LMNA SMARCAD1 SMARCAD1 DDB1 DDB1 ESCO2 ESCO2 APLF APLF NBN NBN TONSL TONSL POLL POLL SLF1 SLF1 NABP1 NABP1 RAD51 RAD51 REC114 REC114 ARPC5 ARPC5 SIRT7 SIRT7 ARPC3 ARPC3 ACTR3 ACTR3 SMC6 SMC6 INTS3 INTS3 POLH POLH CNTD1 CNTD1 NHEJ1 NHEJ1 WDR70 WDR70 RFWD3 RFWD3 RIF1 RIF1 ZBTB7A ZBTB7A SLF2 SLF2 UFL1 UFL1 ATF2 ATF2 SMARCAL1 SMARCAL1 SIRT6 SIRT6 TP53 TP53 SMC5 SMC5 PARP1 PARP1 XRCC4 XRCC4 HUS1 HUS1 FAM178B FAM178B VCP VCP ARPC2 ARPC2 ENSECAP00000042326 ENSECAP00000042326 SHLD2 SHLD2 RNF138 RNF138 RAD18 RAD18 ACTR3B ACTR3B SMCHD1 SMCHD1 ZGRF1 ZGRF1 ARPC4 ARPC4 SMARCA5 SMARCA5 RBBP8 RBBP8 PARP3 PARP3 WAS WAS PNKP PNKP
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MRE11Double-strand break repair protein; Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing. (708 aa)
PHF1PHD finger protein 1. (567 aa)
TIMELESSTimeless circadian regulator. (1211 aa)
RNF168E3 ubiquitin-protein ligase RNF168; E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recrui [...] (573 aa)
HELBDNA helicase B. (1078 aa)
RPA3Replication protein A3. (121 aa)
PRPF19Pre-mRNA processing factor 19. (504 aa)
NABP2Nucleic acid binding protein 2. (256 aa)
WRAP53WD repeat containing antisense to TP53. (540 aa)
INIPSOSS complex subunit C-like protein. (104 aa)
TP53BP1Tumor protein p53 binding protein 1. (1945 aa)
PAXXPAXX non-homologous end joining factor. (308 aa)
SAMHD1SAM and HD domain containing deoxynucleoside triphosphate triphosphohydrolase 1. (670 aa)
RNF169Ring finger protein 169. (708 aa)
RAD50RAD50 double strand break repair protein. (1312 aa)
F7AQP3_HORSEUncharacterized protein. (441 aa)
LMNALamin A/C; Belongs to the intermediate filament family. (663 aa)
SMARCAD1Uncharacterized protein. (1029 aa)
DDB1Damage specific DNA binding protein 1. (1183 aa)
ESCO2Establishment of sister chromatid cohesion N-acetyltransferase 2. (623 aa)
APLFAprataxin and PNKP like factor. (512 aa)
NBNNibrin; Component of the MRE11-RAD50-NBN (MRN complex) which plays a critical role in the cellular response to DNA damage and the maintenance of chromosome integrity. The complex is involved in double- strand break (DSB) repair, DNA recombination, maintenance of telomere integrity, cell cycle checkpoint control and meiosis. (781 aa)
TONSLTonsoku like, DNA repair protein. (1369 aa)
POLLDNA polymerase; DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template- independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity. (575 aa)
SLF1SMC5-SMC6 complex localization factor 1. (1059 aa)
NABP1Nucleic acid binding protein 1. (258 aa)
RAD51DNA repair protein RAD51 homolog; Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination. Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Belongs to the RecA family. RAD51 sub [...] (339 aa)
REC114REC114 meiotic recombination protein. (265 aa)
ARPC5Actin-related protein 2/3 complex subunit 5; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. (154 aa)
SIRT7Sirtuin 7. (400 aa)
ARPC3Actin-related protein 2/3 complex subunit 3; Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (178 aa)
ACTR3Actin related protein 3; Belongs to the actin family. (418 aa)
SMC6Structural maintenance of chromosomes 6. (1101 aa)
INTS3Integrator complex subunit 3. (1040 aa)
POLHDNA polymerase eta. (713 aa)
CNTD1Cyclin N-terminal domain containing 1. (329 aa)
NHEJ1Non-homologous end joining factor 1. (309 aa)
WDR70WD repeat domain 70. (654 aa)
RFWD3Ring finger and WD repeat domain 3. (900 aa)
RIF1Replication timing regulatory factor 1. (2476 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (794 aa)
SLF2SMC5-SMC6 complex localization factor 2. (1171 aa)
UFL1UFM1 specific ligase 1. (791 aa)
ATF2Activating transcription factor 2. (512 aa)
SMARCAL1SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a like 1; Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily. (1106 aa)
SIRT6Sirtuin 6. (407 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
SMC5Structural maintenance of chromosomes 5. (1103 aa)
PARP1Poly [ADP-ribose] polymerase; Poly-ADP-ribosyltransferase that mediates poly-ADP- ribosylation of proteins and plays a key role in DNA repair. (1014 aa)
XRCC4X-ray repair cross complementing 4. (333 aa)
HUS1Checkpoint protein; Belongs to the HUS1 family. (330 aa)
FAM178BFamily with sequence similarity 178 member B. (119 aa)
VCPValosin containing protein; Belongs to the AAA ATPase family. (822 aa)
ARPC2Arp2/3 complex 34 kDa subunit; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. (301 aa)
ENSECAP00000042326Uncharacterized protein. (127 aa)
SHLD2Shieldin complex subunit 2. (1081 aa)
RNF138Ring finger protein 138. (290 aa)
RAD18RAD18 E3 ubiquitin protein ligase. (550 aa)
ACTR3BUncharacterized protein; Belongs to the actin family. (465 aa)
SMCHD1Structural maintenance of chromosomes flexible hinge domain containing 1. (2899 aa)
ZGRF1Zinc finger GRF-type containing 1. (2169 aa)
ARPC4Actin-related protein 2/3 complex subunit 4; Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament; Belongs to the ARPC4 family. (186 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1105 aa)
RBBP8RB binding protein 8, endonuclease. (934 aa)
PARP3Poly [ADP-ribose] polymerase. (537 aa)
WASWASP actin nucleation promoting factor. (605 aa)
PNKPPolynucleotide kinase 3'-phosphatase. (639 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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