STRINGSTRING
JAG1 JAG1 SMAD6 SMAD6 EYA1 EYA1 LRP2 LRP2 EDNRA EDNRA HECTD1 HECTD1 LEP LEP NPRL3 NPRL3 AK1 AK1 ACVRL1 ACVRL1 PLXND1 PLXND1 SEC24B SEC24B NKX3-1 NKX3-1 TFAP2E TFAP2E CHD7 CHD7 APLNR APLNR DCTN5 DCTN5 SRF SRF EGR2 EGR2 FOXH1 FOXH1 DLL4 DLL4 TAB1 TAB1 FKBP10 FKBP10 PRDM1 PRDM1 HES1 HES1 COL3A1 COL3A1 TBX2 TBX2 PKD2 PKD2 BMPR1A BMPR1A SUFU SUFU PROX1 PROX1 PRICKLE1 PRICKLE1 NGFR NGFR TFAP2B TFAP2B LOX LOX
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
LRP2LDL receptor related protein 2. (4673 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
HECTD1HECT domain E3 ubiquitin protein ligase 1. (2610 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
NPRL3NPR3 like, GATOR1 complex subunit. (664 aa)
AK1Endoglin. (848 aa)
ACVRL1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (517 aa)
PLXND1Plexin D1. (2046 aa)
SEC24BSEC24 homolog B, COPII coat complex component. (1205 aa)
NKX3-1NK3 homeobox 1. (240 aa)
TFAP2ETranscription factor AP-2 epsilon. (555 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
DCTN5Dynactin subunit 5-like protein. (182 aa)
SRFSerum response factor. (512 aa)
EGR2Early growth response 2. (486 aa)
FOXH1Forkhead box H1. (360 aa)
DLL4Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
TAB1TGF-beta activated kinase 1 (MAP3K7) binding protein 1. (654 aa)
FKBP10Peptidylprolyl isomerase. (583 aa)
PRDM1PR/SET domain 1. (824 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
COL3A1Collagen type III alpha 1 chain. (1466 aa)
TBX2T-box transcription factor 2. (755 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SUFUSUFU negative regulator of hedgehog signaling. (566 aa)
PROX1Prospero homeobox 1. (737 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
NGFRNerve growth factor receptor. (435 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
LOXLysyl oxidase. (481 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (22%) [HD]