(18 nodes) Response to muscle stretch network (Equus caballus)

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Your Input:
	RYR2	Ryanodine receptor 2. (4967 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (814 aa)
	TCAP	Titin-cap. (166 aa)
	RELA	RELA proto-oncogene, NF-kB subunit. (551 aa)
	FOS	Fos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
	PIK3CA	Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
	CSRP3	Cysteine and glycine rich protein 3. (205 aa)
	CAV3	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family. (225 aa)
	NFKBIA	NFKB inhibitor alpha. (543 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
	GSN	Gelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
	ANKRD1	Ankyrin repeat domain 1. (381 aa)
	LOC111771872	Uncharacterized protein. (242 aa)
	ANKRD23	Ankyrin repeat domain 23. (336 aa)
	ENSECAP00000039203	Uncharacterized protein. (223 aa)
	SLC8A3	Solute carrier family 8 member A3; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (928 aa)
	ENSECAP00000050004	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (323 aa)
	RAF1	Raf-1 proto-oncogene, serine/threonine kinase. (668 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANKRD1	CSRP3	ENSECAP00000031096	ENSECAP00000013771	Ankyrin repeat domain 1.	Cysteine and glycine rich protein 3.	0.452
ANKRD1	LOC111771872	ENSECAP00000031096	ENSECAP00000032467	Ankyrin repeat domain 1.	Uncharacterized protein.	0.452
ANKRD1	RYR2	ENSECAP00000031096	ENSECAP00000007371	Ankyrin repeat domain 1.	Ryanodine receptor 2.	0.458
ANKRD1	TCAP	ENSECAP00000031096	ENSECAP00000009651	Ankyrin repeat domain 1.	Titin-cap.	0.514
CAV3	CSRP3	ENSECAP00000018124	ENSECAP00000013771	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Cysteine and glycine rich protein 3.	0.560
CAV3	LOC111771872	ENSECAP00000018124	ENSECAP00000032467	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Uncharacterized protein.	0.560
CAV3	RYR2	ENSECAP00000018124	ENSECAP00000007371	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Ryanodine receptor 2.	0.579
CAV3	TCAP	ENSECAP00000018124	ENSECAP00000009651	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	Titin-cap.	0.474
CSRP3	ANKRD1	ENSECAP00000013771	ENSECAP00000031096	Cysteine and glycine rich protein 3.	Ankyrin repeat domain 1.	0.452
CSRP3	CAV3	ENSECAP00000013771	ENSECAP00000018124	Cysteine and glycine rich protein 3.	Caveolin; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity; Belongs to the caveolin family.	0.560
CSRP3	TCAP	ENSECAP00000013771	ENSECAP00000009651	Cysteine and glycine rich protein 3.	Titin-cap.	0.874
ENSECAP00000039203	ENSECAP00000050004	ENSECAP00000039203	ENSECAP00000050004	Uncharacterized protein.	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	0.899
ENSECAP00000050004	ENSECAP00000039203	ENSECAP00000050004	ENSECAP00000039203	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Uncharacterized protein.	0.899
ENSECAP00000050004	RAF1	ENSECAP00000050004	ENSECAP00000054163	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily.	Raf-1 proto-oncogene, serine/threonine kinase.	0.436
FOS	JUN	ENSECAP00000011892	ENSECAP00000021482	Fos proto-oncogene, AP-1 transcription factor subunit.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.999
FOS	NFKBIA	ENSECAP00000011892	ENSECAP00000020980	Fos proto-oncogene, AP-1 transcription factor subunit.	NFKB inhibitor alpha.	0.660
FOS	RELA	ENSECAP00000011892	ENSECAP00000011798	Fos proto-oncogene, AP-1 transcription factor subunit.	RELA proto-oncogene, NF-kB subunit.	0.536
JUN	FOS	ENSECAP00000021482	ENSECAP00000011892	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	Fos proto-oncogene, AP-1 transcription factor subunit.	0.999
JUN	NFKBIA	ENSECAP00000021482	ENSECAP00000020980	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	NFKB inhibitor alpha.	0.589
JUN	RELA	ENSECAP00000021482	ENSECAP00000011798	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	RELA proto-oncogene, NF-kB subunit.	0.605