(22 nodes) Pattern recognition receptor activity network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Known Interactions

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Predicted Interactions

gene neighborhood

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Your Input:
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	PGLYRP2	Peptidoglycan recognition protein 2. (517 aa)
	PGLYRP4	Peptidoglycan recognition protein 4. (375 aa)
	PGLYRP3	Peptidoglycan recognition protein 3. (341 aa)
	TLR9	Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
	NOD2	Nucleotide binding oligomerization domain containing 2. (1013 aa)
	LY96	Lymphocyte antigen 96. (173 aa)
	LOC100071074	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (193 aa)
	SCARB1	Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa)
	TLR7	Toll like receptor 7; Belongs to the Toll-like receptor family. (1054 aa)
	NLRP6	NLR family pyrin domain containing 6. (892 aa)
	ENSECAP00000031054	Uncharacterized protein. (397 aa)
	LOC100069029	Fibrinogen C-terminal domain-containing protein. (442 aa)
	COLEC12	Collectin subfamily member 12. (754 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)
	NOD1	Nucleotide binding oligomerization domain containing 1. (993 aa)
	CLEC6A	C-type lectin domain containing 6A. (232 aa)
	TLR8	Toll-like receptor 8; Belongs to the Toll-like receptor family. (1038 aa)
	CLEC4E	C-type lectin domain family 4 member E. (217 aa)
	TNFAIP8L2	TNF alpha induced protein 8 like 2. (184 aa)
	LOC100054534	Uncharacterized protein. (511 aa)
	CLEC4D	C-type lectin domain family 4 member D. (216 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CLEC4D	CLEC4E	ENSECAP00000007844	ENSECAP00000006339	C-type lectin domain family 4 member D.	C-type lectin domain family 4 member E.	0.980
CLEC4D	CLEC6A	ENSECAP00000007844	ENSECAP00000046524	C-type lectin domain family 4 member D.	C-type lectin domain containing 6A.	0.503
CLEC4E	CLEC4D	ENSECAP00000006339	ENSECAP00000007844	C-type lectin domain family 4 member E.	C-type lectin domain family 4 member D.	0.980
CLEC4E	CLEC6A	ENSECAP00000006339	ENSECAP00000046524	C-type lectin domain family 4 member E.	C-type lectin domain containing 6A.	0.435
CLEC4E	LOC100069029	ENSECAP00000006339	ENSECAP00000031116	C-type lectin domain family 4 member E.	Fibrinogen C-terminal domain-containing protein.	0.444
CLEC6A	CLEC4D	ENSECAP00000046524	ENSECAP00000007844	C-type lectin domain containing 6A.	C-type lectin domain family 4 member D.	0.503
CLEC6A	CLEC4E	ENSECAP00000046524	ENSECAP00000006339	C-type lectin domain containing 6A.	C-type lectin domain family 4 member E.	0.435
CLEC6A	LOC111771935	ENSECAP00000046524	ENSECAP00000033420	C-type lectin domain containing 6A.	Toll-like receptor 4.	0.422
CLEC6A	TLR4	ENSECAP00000046524	ENSECAP00000008292	C-type lectin domain containing 6A.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.425
COLEC12	LOC100071074	ENSECAP00000032296	ENSECAP00000015762	Collectin subfamily member 12.	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.	0.636
LOC100069029	CLEC4E	ENSECAP00000031116	ENSECAP00000006339	Fibrinogen C-terminal domain-containing protein.	C-type lectin domain family 4 member E.	0.444
LOC100071074	COLEC12	ENSECAP00000015762	ENSECAP00000032296	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.	Collectin subfamily member 12.	0.636
LOC100071074	NOD2	ENSECAP00000015762	ENSECAP00000015042	Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity.	Nucleotide binding oligomerization domain containing 2.	0.460
LOC111771935	CLEC6A	ENSECAP00000033420	ENSECAP00000046524	Toll-like receptor 4.	C-type lectin domain containing 6A.	0.422
LOC111771935	LY96	ENSECAP00000033420	ENSECAP00000015094	Toll-like receptor 4.	Lymphocyte antigen 96.	0.993
LOC111771935	NOD1	ENSECAP00000033420	ENSECAP00000042403	Toll-like receptor 4.	Nucleotide binding oligomerization domain containing 1.	0.780
LOC111771935	NOD2	ENSECAP00000033420	ENSECAP00000015042	Toll-like receptor 4.	Nucleotide binding oligomerization domain containing 2.	0.837
LOC111771935	SCARB1	ENSECAP00000033420	ENSECAP00000021884	Toll-like receptor 4.	Scavenger receptor class B member 1; Belongs to the CD36 family.	0.578
LOC111771935	TLR4	ENSECAP00000033420	ENSECAP00000008292	Toll-like receptor 4.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.824
LOC111771935	TLR7	ENSECAP00000033420	ENSECAP00000024910	Toll-like receptor 4.	Toll like receptor 7; Belongs to the Toll-like receptor family.	0.597