(18 nodes) Myeloid dendritic cell differentiation network (Equus caballus)

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Your Input:
	LOC100063866	AIG1-type G domain-containing protein. (413 aa)
	CAMK4	Calcium/calmodulin dependent protein kinase IV; Belongs to the protein kinase superfamily. (473 aa)
	DCSTAMP	Dendrocyte expressed seven transmembrane protein. (470 aa)
	ITGB8	Integrin beta; Belongs to the integrin beta chain family. (767 aa)
	RELB	RELB proto-oncogene, NF-kB subunit. (709 aa)
	TRAF6	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
	IRF4	Interferon regulatory factor 4. (606 aa)
	ENSECAP00000033220	AIG1-type G domain-containing protein. (267 aa)
	LOC100146250	AIG1-type G domain-containing protein. (315 aa)
	LTBR	Lymphotoxin beta receptor. (434 aa)
	BATF2	Basic leucine zipper ATF-like transcription factor 2. (272 aa)
	LOC100630393	AIG1-type G domain-containing protein. (315 aa)
	NOTCH2	Notch receptor 2. (2471 aa)
	IL4	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
	CSF2	Granulocyte-macrophage colony-stimulating factor. (152 aa)
	BATF3	Basic leucine zipper ATF-like transcription factor 3. (253 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	BATF	Basic leucine zipper ATF-like transcription factor. (125 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BATF	BATF2	ENSECAP00000013962	ENSECAP00000043910	Basic leucine zipper ATF-like transcription factor.	Basic leucine zipper ATF-like transcription factor 2.	0.913
BATF	BATF3	ENSECAP00000013962	ENSECAP00000008879	Basic leucine zipper ATF-like transcription factor.	Basic leucine zipper ATF-like transcription factor 3.	0.915
BATF	IRF4	ENSECAP00000013962	ENSECAP00000027192	Basic leucine zipper ATF-like transcription factor.	Interferon regulatory factor 4.	0.830
BATF2	BATF	ENSECAP00000043910	ENSECAP00000013962	Basic leucine zipper ATF-like transcription factor 2.	Basic leucine zipper ATF-like transcription factor.	0.913
BATF2	BATF3	ENSECAP00000043910	ENSECAP00000008879	Basic leucine zipper ATF-like transcription factor 2.	Basic leucine zipper ATF-like transcription factor 3.	0.927
BATF3	BATF	ENSECAP00000008879	ENSECAP00000013962	Basic leucine zipper ATF-like transcription factor 3.	Basic leucine zipper ATF-like transcription factor.	0.915
BATF3	BATF2	ENSECAP00000008879	ENSECAP00000043910	Basic leucine zipper ATF-like transcription factor 3.	Basic leucine zipper ATF-like transcription factor 2.	0.927
BATF3	IRF4	ENSECAP00000008879	ENSECAP00000027192	Basic leucine zipper ATF-like transcription factor 3.	Interferon regulatory factor 4.	0.748
CSF2	IL4	ENSECAP00000007561	ENSECAP00000006431	Granulocyte-macrophage colony-stimulating factor.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.919
CSF2	IRF4	ENSECAP00000007561	ENSECAP00000027192	Granulocyte-macrophage colony-stimulating factor.	Interferon regulatory factor 4.	0.407
CSF2	TGFB1	ENSECAP00000007561	ENSECAP00000009480	Granulocyte-macrophage colony-stimulating factor.	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.500
DCSTAMP	TRAF6	ENSECAP00000016680	ENSECAP00000018618	Dendrocyte expressed seven transmembrane protein.	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.483
IL4	CSF2	ENSECAP00000006431	ENSECAP00000007561	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Granulocyte-macrophage colony-stimulating factor.	0.919
IL4	IRF4	ENSECAP00000006431	ENSECAP00000027192	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Interferon regulatory factor 4.	0.707
IL4	TGFB1	ENSECAP00000006431	ENSECAP00000009480	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...]	0.773
IL4	TRAF6	ENSECAP00000006431	ENSECAP00000018618	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family.	0.445
IRF4	BATF	ENSECAP00000027192	ENSECAP00000013962	Interferon regulatory factor 4.	Basic leucine zipper ATF-like transcription factor.	0.830
IRF4	BATF3	ENSECAP00000027192	ENSECAP00000008879	Interferon regulatory factor 4.	Basic leucine zipper ATF-like transcription factor 3.	0.748
IRF4	CSF2	ENSECAP00000027192	ENSECAP00000007561	Interferon regulatory factor 4.	Granulocyte-macrophage colony-stimulating factor.	0.407
IRF4	IL4	ENSECAP00000027192	ENSECAP00000006431	Interferon regulatory factor 4.	Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...]	0.707