STRINGSTRING
TRAF6 TRAF6 EPHA4 EPHA4 TLR9 TLR9 SASH1 SASH1 FZD4 FZD4 FGD2 FGD2 ERN2 ERN2 PAK1 PAK1 AGER AGER ARHGEF5 ARHGEF5 AXIN1 AXIN1 PTPN1 PTPN1 DAB2IP DAB2IP SYK SYK MAP3K5 MAP3K5 MAP3K4 MAP3K4 MAP3K11 MAP3K11 TAOK3 TAOK3 EDN1 EDN1 LOC111770212 LOC111770212 TNFRSF11A TNFRSF11A MAP3K7 MAP3K7 ERN1 ERN1 MAP3K12 MAP3K12 DVL3 DVL3 MAP3K13 MAP3K13 MAP4K2 MAP4K2 DVL2 DVL2 TNF TNF FZD10 FZD10 ENSECAP00000051121 ENSECAP00000051121 MAP3K10 MAP3K10 TRAF2 TRAF2 RPS3 RPS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
EPHA4EPH receptor A4. (949 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
SASH1SAM and SH3 domain containing 1. (1234 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
FGD2FYVE, RhoGEF and PH domain containing 2. (657 aa)
ERN2Endoplasmic reticulum to nucleus signaling 2. (926 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1687 aa)
AXIN1Axin 1. (939 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (493 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
SYKTyrosine-protein kinase. (716 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
MAP3K4Mitogen-activated protein kinase kinase kinase 4. (1603 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
TAOK3TAO kinase 3. (914 aa)
EDN1Endothelin 1. (202 aa)
LOC111770212C-C motif chemokine. (100 aa)
TNFRSF11ATNF receptor superfamily member 11a. (647 aa)
MAP3K7Mitogen-activated protein kinase kinase kinase 7; Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. (615 aa)
ERN1Endoplasmic reticulum to nucleus signaling 1. (974 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
DVL3Dishevelled segment polarity protein 3. (716 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
FZD10Frizzled class receptor 10; Belongs to the G-protein coupled receptor Fz/Smo family. (581 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (931 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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