(62 nodes) Dicarboxylic acid metabolic process network (Equus caballus)

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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second shell of interactors

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proteins of unknown 3D structure

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Predicted Interactions

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	AMDHD1	Amidohydrolase domain containing 1. (426 aa)
	ME1	Malic enzyme. (636 aa)
	LOC100050480	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (599 aa)
	MTHFD1L	Methylenetetrahydrofolate dehydrogenase (NADP+ dependent) 1 like. (978 aa)
	ACOT8	Acyl-CoA thioesterase 8. (429 aa)
	ME2	Malic enzyme. (584 aa)
	DLST	Dihydrolipoamide S-succinyltransferase. (659 aa)
	ACLY	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. (1141 aa)
	MDH1B	Malate dehydrogenase 1B. (598 aa)
	ASL	Argininosuccinate lyase. (660 aa)
	KYAT3	Kynurenine aminotransferase 3. (511 aa)
	TAT	Tyrosine aminotransferase; Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. (459 aa)
	D2HGDH	D-2-hydroxyglutarate dehydrogenase. (559 aa)
	ENSECAP00000034812	Uncharacterized protein. (157 aa)
	KMO	Kynurenine 3-monooxygenase; Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract. (527 aa)
	MTHFD1	Methylenetetrahydrofolate dehydrogenase, cyclohydrolase and formyltetrahydrofolate synthetase 1. (941 aa)
	LOC111772327	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family. (328 aa)
	SHMT2	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (550 aa)
	PRODH2	Proline dehydrogenase; Converts proline to delta-1-pyrroline-5-carboxylate. (460 aa)
	HOGA1	4-hydroxy-2-oxoglutarate aldolase 1. (353 aa)
	FTCDNL1	Formiminotransferase cyclodeaminase N-terminal like. (220 aa)
	SDHA	Succinate dehydrogenase [ubiquinone] flavoprotein subunit, mitochondrial; Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). (677 aa)
	UROC1	Urocanate hydratase 1. (677 aa)
	MRPS36	Mitochondrial ribosomal protein S36. (103 aa)
	QPRT	Quinolinate phosphoribosyltransferase. (350 aa)
	FPGS	Folylpolyglutamate synthase; Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis; Belongs to the folylpolyglutamate synthase family. (619 aa)
	MDH1	Malate dehydrogenase. (352 aa)
	IDH2	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family. (424 aa)
	HAAO	3-hydroxyanthranilate 3,4-dioxygenase; Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate; Belongs to the 3-HAO family. (315 aa)
	KYNU	Kynureninase; Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3- hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3- hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity. Belongs to the kynureninase family. (486 aa)
	ALDH5A1	Aldehyde dehydrogenase 5 family member A1. (725 aa)
	FH	Fumarate hydratase. (508 aa)
	ALDH1L1	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (902 aa)
	NIT2	Nitrilase family member 2. (283 aa)
	GLS2	Glutaminase 2. (602 aa)
	GCLM	Glutamate-cysteine ligase modifier subunit. (274 aa)
	MDH2	Malate dehydrogenase. (338 aa)
	MTRR	5-methyltetrahydrofolate-homocysteine methyltransferase reductase. (786 aa)
	GOT1	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...] (423 aa)
	SDHAF3	Succinate dehydrogenase complex assembly factor 3. (125 aa)
	ADHFE1	Alcohol dehydrogenase iron containing 1. (507 aa)
	DDO	D-aspartate oxidase. (389 aa)
	ASS1	Argininosuccinate synthase 1. (509 aa)
	ME3	Malic enzyme. (604 aa)
	HAL	Histidine ammonia-lyase; Belongs to the PAL/histidase family. (657 aa)
	LOC100055638	Uncharacterized protein. (513 aa)
	GLS	Glutaminase. (673 aa)
	ALDH4A1	Aldehyde dehydrogenase 4 family member A1; Belongs to the aldehyde dehydrogenase family. (498 aa)
	FTCD	Formimidoyltransferase cyclodeaminase. (541 aa)
	IDH1	Isocitrate dehydrogenase (NADP(+)) 1, cytosolic. (641 aa)
	NAGS	N-acetylglutamate synthase. (529 aa)
	GAD1	Glutamate decarboxylase 1. (594 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	OAT	Ornithine aminotransferase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. (446 aa)
	ACSF3	Acyl-CoA synthetase family member 3. (585 aa)
	GOT1L1	Glutamic-oxaloacetic transaminase 1 like 1. (416 aa)
	SHMT1	Serine hydroxymethyltransferase; Interconversion of serine and glycine. Belongs to the SHMT family. (484 aa)
	GOT2	Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity). (430 aa)
	ALDH18A1	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. (795 aa)
	GCLC	Glutamate-cysteine ligase catalytic subunit. (637 aa)
	OGDH	Oxoglutarate dehydrogenase. (1052 aa)
	ALDH1L2	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily. (923 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ACLY	ACSF3	ENSECAP00000028665	ENSECAP00000012884	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Acyl-CoA synthetase family member 3.	0.426
ACLY	ALDH18A1	ENSECAP00000028665	ENSECAP00000015003	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Delta-1-pyrroline-5-carboxylate synthase; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.	0.495
ACLY	ALDH1L1	ENSECAP00000028665	ENSECAP00000018494	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.409
ACLY	ALDH1L2	ENSECAP00000028665	ENSECAP00000021722	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	10-formyltetrahydrofolate dehydrogenase; In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.	0.414
ACLY	ALDH4A1	ENSECAP00000028665	ENSECAP00000010053	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aldehyde dehydrogenase 4 family member A1; Belongs to the aldehyde dehydrogenase family.	0.473
ACLY	ALDH5A1	ENSECAP00000028665	ENSECAP00000018194	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aldehyde dehydrogenase 5 family member A1.	0.897
ACLY	ASL	ENSECAP00000028665	ENSECAP00000030718	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Argininosuccinate lyase.	0.844
ACLY	DDO	ENSECAP00000028665	ENSECAP00000005482	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	D-aspartate oxidase.	0.808
ACLY	DLST	ENSECAP00000028665	ENSECAP00000026727	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Dihydrolipoamide S-succinyltransferase.	0.793
ACLY	FH	ENSECAP00000028665	ENSECAP00000018408	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Fumarate hydratase.	0.588
ACLY	GOT1	ENSECAP00000028665	ENSECAP00000000135	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase, cytoplasmic; Biosynthesis of L-glutamate from L-aspartate or L-cysteine. Important regulator of levels of glutamate, the major excitatory neurotransmitter of the vertebrate central nervous system. Acts as a scavenger of glutamate in brain neuroprotection. The aspartate aminotransferase activity is involved in hepatic glucose synthesis during development and in adipocyte glyceroneogenesis. Using L-cysteine as substrate, regulates levels of mercaptopyruvate, an important source of hydrogen sulfide. Mercaptopyruvate is converted into H(2)S via the action of 3-m [...]	0.853
ACLY	GOT1L1	ENSECAP00000028665	ENSECAP00000013482	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Glutamic-oxaloacetic transaminase 1 like 1.	0.843
ACLY	GOT2	ENSECAP00000028665	ENSECAP00000014550	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aspartate aminotransferase, mitochondrial; Catalyzes the irreversible transamination of the L-tryptophan metabolite L-kynurenine to form kynurenic acid (KA). Plays a key role in amino acid metabolism. Important for metabolite exchange between mitochondria and cytosol. Facilitates cellular uptake of long-chain free fatty acids (By similarity).	0.854
ACLY	IDH1	ENSECAP00000028665	ENSECAP00000010194	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase (NADP(+)) 1, cytosolic.	0.820
ACLY	IDH2	ENSECAP00000028665	ENSECAP00000052052	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Isocitrate dehydrogenase [NADP]; Belongs to the isocitrate and isopropylmalate dehydrogenases family.	0.828
ACLY	LOC111772327	ENSECAP00000028665	ENSECAP00000038529	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Aldedh domain-containing protein; Belongs to the aldehyde dehydrogenase family.	0.470
ACLY	MDH1	ENSECAP00000028665	ENSECAP00000051105	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.969
ACLY	MDH1B	ENSECAP00000028665	ENSECAP00000030013	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase 1B.	0.580
ACLY	MDH2	ENSECAP00000028665	ENSECAP00000020738	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malate dehydrogenase.	0.970
ACLY	ME1	ENSECAP00000028665	ENSECAP00000022158	ATP-citrate synthase; Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis; In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family.	Malic enzyme.	0.493