(64 nodes) Cellular response to fibroblast growth factor stimulus network (Equus caballus)

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second shell of interactors

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Your Input:
	FGF23	Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
	SHCBP1	SHC binding and spindle associated 1. (759 aa)
	SPRY2	Sprouty RTK signaling antagonist 2. (315 aa)
	FLRT3	Fibronectin leucine rich transmembrane protein 3. (610 aa)
	DSTYK	Dual serine/threonine and tyrosine protein kinase. (928 aa)
	KL	Klotho. (1011 aa)
	FLRT2	Fibronectin leucine rich transmembrane protein 2. (660 aa)
	GRB2	Growth factor receptor bound protein 2. (217 aa)
	FGF21	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
	CEP57	Centrosomal protein 57. (501 aa)
	NDNF	Neuron derived neurotrophic factor. (568 aa)
	CXCL13	C-X-C motif chemokine. (110 aa)
	DLL4	Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (685 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	PRDM14	PR/SET domain 14. (598 aa)
	FGF2	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
	CXCL8	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa)
	FGF7	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (194 aa)
	FGF5	Fibroblast growth factor 5. (280 aa)
	CCN2	Cellular communication network factor 2. (475 aa)
	HYAL2	Hyaluronidase. (710 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (510 aa)
	NGFR	Nerve growth factor receptor. (435 aa)
	FGF9	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	EXT2	Exostosin glycosyltransferase 2; Belongs to the glycosyltransferase 47 family. (750 aa)
	FGFR3	Fibroblast growth factor receptor. (804 aa)
	SOS1	SOS Ras/Rac guanine nucleotide exchange factor 1. (1613 aa)
	FGFR4	Fibroblast growth factor receptor. (855 aa)
	FGF8	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
	FGFR2	Fibroblast growth factor receptor. (887 aa)
	EGR3	Early growth response 3. (387 aa)
	FGFR1	Fibroblast growth factor receptor. (877 aa)
	ZFP36	Uncharacterized protein. (662 aa)
	LOC100067177	Beta_helix domain-containing protein. (616 aa)
	RAB14	RAB14, member RAS oncogene family. (260 aa)
	IQGAP1	IQ motif containing GTPase activating protein 1. (2101 aa)
	FGF3	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (231 aa)
	FGF4	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
	FGF20	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (211 aa)
	FRS3	Fibroblast growth factor receptor substrate 3. (545 aa)
	FRS2	Fibroblast growth factor receptor substrate 2. (515 aa)
	KDM5B	Lysine demethylase 5B. (1536 aa)
	FGFRL1	Fibroblast growth factor receptor like 1. (522 aa)
	SETX	Senataxin. (2680 aa)
	CD44	CD44 antigen. (700 aa)
	FGF12	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (235 aa)
	FGF22	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (172 aa)
	FGF16	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	FGF18	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
	CRKL	CRK like proto-oncogene, adaptor protein. (303 aa)
	FGF19	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
	FGF17	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (240 aa)
	PTPN11	Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
	TBX2	T-box transcription factor 2. (755 aa)
	ITGB1BP1	Integrin subunit beta 1 binding protein 1. (200 aa)
	CCL2	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
	EXT1	Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
	KLB	Klotho beta. (1045 aa)
	FIBP	FGF1 intracellular binding protein. (357 aa)
	FGF6	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
	SFRP1	Secreted frizzled related protein 1. (314 aa)
	FGF1	Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CCL2	CCN2	ENSECAP00000021376	ENSECAP00000014264	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Cellular communication network factor 2.	0.496
CCL2	CD44	ENSECAP00000021376	ENSECAP00000031627	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	CD44 antigen.	0.642
CCL2	CXCL13	ENSECAP00000021376	ENSECAP00000009631	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	C-X-C motif chemokine.	0.982
CCL2	CXCL8	ENSECAP00000021376	ENSECAP00000013083	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity).	0.638
CCL2	FGF2	ENSECAP00000021376	ENSECAP00000012430	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.582
CCL2	KL	ENSECAP00000021376	ENSECAP00000006226	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Klotho.	0.471
CCL2	KLB	ENSECAP00000021376	ENSECAP00000020332	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	Klotho beta.	0.471
CCN2	CCL2	ENSECAP00000014264	ENSECAP00000021376	Cellular communication network factor 2.	C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...]	0.496
CCN2	CD44	ENSECAP00000014264	ENSECAP00000031627	Cellular communication network factor 2.	CD44 antigen.	0.486
CCN2	FGF10	ENSECAP00000014264	ENSECAP00000012063	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.482
CCN2	FGF12	ENSECAP00000014264	ENSECAP00000030827	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CCN2	FGF16	ENSECAP00000014264	ENSECAP00000030025	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.465
CCN2	FGF17	ENSECAP00000014264	ENSECAP00000022201	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CCN2	FGF18	ENSECAP00000014264	ENSECAP00000027831	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.478
CCN2	FGF19	ENSECAP00000014264	ENSECAP00000023614	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458
CCN2	FGF2	ENSECAP00000014264	ENSECAP00000012430	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.610
CCN2	FGF20	ENSECAP00000014264	ENSECAP00000039059	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.464
CCN2	FGF21	ENSECAP00000014264	ENSECAP00000008552	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.476
CCN2	FGF22	ENSECAP00000014264	ENSECAP00000030169	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.469
CCN2	FGF3	ENSECAP00000014264	ENSECAP00000039631	Cellular communication network factor 2.	Fibroblast growth factor; Belongs to the heparin-binding growth factors family.	0.458