node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
CREB1 | FOS | ENSECAP00000011555 | ENSECAP00000011892 | cAMP responsive element binding protein 1. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.769 |
CREB1 | IFNG | ENSECAP00000011555 | ENSECAP00000030547 | cAMP responsive element binding protein 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.459 |
CREB1 | NOTCH2 | ENSECAP00000011555 | ENSECAP00000045755 | cAMP responsive element binding protein 1. | Notch receptor 2. | 0.404 |
CREB1 | TNF | ENSECAP00000011555 | ENSECAP00000001460 | cAMP responsive element binding protein 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.504 |
CSF1 | IFNG | ENSECAP00000015309 | ENSECAP00000030547 | Colony stimulating factor 1. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.719 |
CSF1 | IL17A | ENSECAP00000015309 | ENSECAP00000039926 | Colony stimulating factor 1. | Uncharacterized protein. | 0.537 |
CSF1 | TNF | ENSECAP00000015309 | ENSECAP00000001460 | Colony stimulating factor 1. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.693 |
CSF1 | TNFSF11 | ENSECAP00000015309 | ENSECAP00000014214 | Colony stimulating factor 1. | Tumor necrosis factor ligand superfamily member. | 0.542 |
CSF1 | TRAF6 | ENSECAP00000015309 | ENSECAP00000018618 | Colony stimulating factor 1. | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. | 0.458 |
CSF1 | TREM2 | ENSECAP00000015309 | ENSECAP00000012909 | Colony stimulating factor 1. | Triggering receptor expressed on myeloid cells 2. | 0.577 |
FOS | CREB1 | ENSECAP00000011892 | ENSECAP00000011555 | Fos proto-oncogene, AP-1 transcription factor subunit. | cAMP responsive element binding protein 1. | 0.769 |
FOS | IFNG | ENSECAP00000011892 | ENSECAP00000030547 | Fos proto-oncogene, AP-1 transcription factor subunit. | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | 0.439 |
FOS | TNF | ENSECAP00000011892 | ENSECAP00000001460 | Fos proto-oncogene, AP-1 transcription factor subunit. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.483 |
IFNG | CREB1 | ENSECAP00000030547 | ENSECAP00000011555 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | cAMP responsive element binding protein 1. | 0.459 |
IFNG | CSF1 | ENSECAP00000030547 | ENSECAP00000015309 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Colony stimulating factor 1. | 0.719 |
IFNG | FOS | ENSECAP00000030547 | ENSECAP00000011892 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Fos proto-oncogene, AP-1 transcription factor subunit. | 0.439 |
IFNG | IL12B | ENSECAP00000030547 | ENSECAP00000010803 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. | 0.586 |
IFNG | IL17A | ENSECAP00000030547 | ENSECAP00000039926 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Uncharacterized protein. | 0.966 |
IFNG | IL23A | ENSECAP00000030547 | ENSECAP00000019716 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] | 0.674 |
IFNG | TNF | ENSECAP00000030547 | ENSECAP00000001460 | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] | 0.970 |