STRINGSTRING
TREM2 TREM2 FOS FOS CREB1 CREB1 KLF10 KLF10 IL12B IL12B OCSTAMP OCSTAMP SLC9B2 SLC9B2 TMEM64 TMEM64 GPR68 GPR68 TNF TNF NOTCH2 NOTCH2 NEDD9 NEDD9 IL17A IL17A PPP3CA PPP3CA IL20 IL20 IFNG IFNG IL23A IL23A TRAF6 TRAF6 POU4F2 POU4F2 PPARGC1B PPARGC1B CSF1 CSF1 TNFSF11 TNFSF11
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
FOSFos proto-oncogene, AP-1 transcription factor subunit. (381 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
KLF10Kruppel like factor 10. (514 aa)
IL12BInterleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa)
OCSTAMPOsteoclast stimulatory transmembrane protein. (505 aa)
SLC9B2Solute carrier family 9 member B2. (537 aa)
TMEM64Transmembrane protein 64. (416 aa)
GPR68G protein-coupled receptor 68; Belongs to the G-protein coupled receptor 1 family. (389 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
NOTCH2Notch receptor 2. (2471 aa)
NEDD9Neural precursor cell expressed, developmentally down-regulated 9. (834 aa)
IL17AUncharacterized protein. (155 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
IL20Interleukin 20. (248 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
IL23AInterleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
POU4F2POU domain protein. (406 aa)
PPARGC1BPPARG coactivator 1 beta. (1239 aa)
CSF1Colony stimulating factor 1. (630 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (318 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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