STRINGSTRING
MELTF MELTF CAPN3 CAPN3 PRKN PRKN HIP1R HIP1R FBXW9 FBXW9 GRAMD4 GRAMD4 FGFR4 FGFR4 TNFRSF1B TNFRSF1B BCL2L11 BCL2L11 DAPK1 DAPK1 NKD2 NKD2 APH1B APH1B ENSECAP00000051121 ENSECAP00000051121 NOP53 NOP53 KCNE2 KCNE2 LOC111775628 LOC111775628 SH3D19 SH3D19 WDR20 WDR20 DNAJB2 DNAJB2 BCAP31 BCAP31 RNF14 RNF14 DET1 DET1 WDR48 WDR48 PSME1 PSME1 RNF180 RNF180 CAPN9 CAPN9 LOC100061631 LOC100061631 PAWR PAWR HIP1 HIP1 DISC1 DISC1 RP1L1 RP1L1 CCDC22 CCDC22 NOD1 NOD1 NUB1 NUB1 LYN LYN NCSTN NCSTN PMAIP1 PMAIP1 CRADD CRADD CAV1 CAV1 AGBL4 AGBL4 ASPH ASPH GPLD1 GPLD1 SMAD3 SMAD3 HPN HPN CASP8AP2 CASP8AP2 TMEM259 TMEM259 CASP9 CASP9 MAP3K5 MAP3K5 CCBE1 CCBE1 AIM2 AIM2 ADAM8 ADAM8 FZR1 FZR1 SYK SYK DDX3X DDX3X MKRN2 MKRN2 ZYG11B ZYG11B STAT3 STAT3 CTSH CTSH FBXW8 FBXW8 EFNA3 EFNA3 NEK5 NEK5 PSME4 PSME4 ZER1 ZER1 PSMC6 PSMC6 MAPK9 MAPK9 PIAS1 PIAS1 PSMC4 PSMC4 DAB2 DAB2 ENSECAP00000034034 ENSECAP00000034034 CYFIP2 CYFIP2 ENSECAP00000033783 ENSECAP00000033783 SENP1 SENP1 RIPK2 RIPK2 PIDD1 PIDD1 AGTPBP1 AGTPBP1 APH1A APH1A SIRT6 SIRT6 CASP2 CASP2 IFNG IFNG RNF217 RNF217 RNF144A RNF144A SIRT1 SIRT1 SIRT2 SIRT2 DAP DAP OSBPL7 OSBPL7 FIS1 FIS1 LOC100061598 LOC100061598 BBS7 BBS7 PSME3 PSME3 ARIH1 ARIH1 NLRP6 NLRP6 BTRC BTRC PSMC2 PSMC2 COP1 COP1 GSN GSN CLDN3 CLDN3 FBLN1 FBLN1 AURKAIP1 AURKAIP1 RNF144B RNF144B ATP2A3 ATP2A3 S100A9 S100A9 FOXL2 FOXL2 LOC102148739 LOC102148739 SNX9 SNX9 BBC3 BBC3 CBFA2T3 CBFA2T3 PSMC5 PSMC5 DAB2IP DAB2IP TANK TANK TNFSF15 TNFSF15 CLEC3B CLEC3B PTK2B PTK2B MTCH1 MTCH1 PACSIN3 PACSIN3 RNF185 RNF185 BCL10 BCL10 CCN1 CCN1 GSK3B GSK3B PSMC3 PSMC3 RAD23A RAD23A SH3RF2 SH3RF2 CASP10 CASP10 OGT OGT BAK1 BAK1 AXIN1 AXIN1 USP50 USP50 F3 F3 PRELID1 PRELID1 LPCAT3 LPCAT3 IST1 IST1 GBA GBA FBXW7 FBXW7 REST REST RACK1 RACK1 NRDC NRDC CLUL1 CLUL1 TFAP4 TFAP4 MYC MYC LOC100055155 LOC100055155 PCOLCE PCOLCE MYH9 MYH9 SH3RF1 SH3RF1 CFLAR CFLAR FADD FADD EFNA1 EFNA1 PDCD6 PDCD6 AGER AGER DVL1 DVL1 SPON1 SPON1 PSMD10 PSMD10 PCOLCE2 PCOLCE2 TMTC3 TMTC3 SMAD7 SMAD7 ZYG11A ZYG11A FAM162A FAM162A DDRGK1 DDRGK1 DIABLO DIABLO ACVR1C ACVR1C CDC20 CDC20 NLRC4 NLRC4 GSK3A GSK3A TRIB1 TRIB1 CARD9 CARD9 SH3RF3 SH3RF3 S100A10 S100A10 PDCD5 PDCD5 PRICKLE1 PRICKLE1 CNTN2 CNTN2 TBC1D10A TBC1D10A GRN GRN PSME2 PSME2 AXIN2 AXIN2 YJEFN3 YJEFN3 VSIR VSIR PLK1 PLK1 RNFT2 RNFT2 SMURF1 SMURF1 NDUFA13 NDUFA13 NGFR NGFR ECSCR ECSCR NLRP12 NLRP12 RNFT1 RNFT1 PRR7 PRR7 ACER2 ACER2 CLN6 CLN6 SFRP2 SFRP2 NODAL NODAL DMWD DMWD CDC20B CDC20B PDCD2 PDCD2 BAX BAX FASLG FASLG UACA UACA PPM1F PPM1F CLPX CLPX RCHY1 RCHY1 ANGPTL8 ANGPTL8 MUL1 MUL1 SNX33 SNX33 NLRP3 NLRP3 TREM2 TREM2 USP5 USP5 BAD BAD NUPR1 NUPR1 STUB1 STUB1 TNP1 TNP1 CYCS CYCS BAG6 BAG6 EPHA4 EPHA4 RPS3 RPS3 FAS FAS MALT1 MALT1 PLGRKT PLGRKT BAG2 BAG2 RNF19B RNF19B SRC SRC DDA1 DDA1 ATP5IF1 ATP5IF1 IFT57 IFT57 HERPUD1 HERPUD1 ASTL ASTL TNIP1 TNIP1 ARIH2 ARIH2 LRRK2 LRRK2 F12 F12 F7DPV9_HORSE F7DPV9_HORSE LGMN LGMN ANKIB1 ANKIB1 CIDEB CIDEB S100A8 S100A8 RCN3 RCN3 TRIB2 TRIB2 SGTA SGTA P2RX1 P2RX1 CSNK1D CSNK1D PYCARD PYCARD TMEM130 TMEM130 ZC3H12A ZC3H12A TRIM32 TRIM32 RNF139 RNF139 NLRP1 NLRP1 F6WH02_HORSE F6WH02_HORSE HMGB1 HMGB1 RNF19A RNF19A RHBDD1 RHBDD1 F7CJH7_HORSE F7CJH7_HORSE PSENEN PSENEN TRIM67 TRIM67 TTBK1 TTBK1 CLU CLU FN1 FN1 MEFV MEFV FBXO22 FBXO22 BID BID CLDN4 CLDN4 USP13 USP13 PML PML CASP8 CASP8 EGLN3 EGLN3 F2R F2R SOCS4 SOCS4 AIFM1 AIFM1 ADRA2A ADRA2A PSMC1 PSMC1 FAM122A FAM122A TNF TNF NKX3-1 NKX3-1 GPER1 GPER1 LAPTM5 LAPTM5 HTRA2 HTRA2 SART3 SART3 TRIB3 TRIB3 FGL2 FGL2 BOK BOK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MELTFMelanotransferrin; Belongs to the transferrin family. (739 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
HIP1RHuntingtin interacting protein 1 related. (1203 aa)
FBXW9F-box and WD repeat domain containing 9. (477 aa)
GRAMD4GRAM domain containing 4. (728 aa)
FGFR4Fibroblast growth factor receptor. (855 aa)
TNFRSF1BTNF receptor superfamily member 1B. (481 aa)
BCL2L11BCL2 like 11. (289 aa)
DAPK1Death associated protein kinase 1. (1457 aa)
NKD2NKD inhibitor of WNT signaling pathway 2. (553 aa)
APH1BAph-1 homolog B, gamma-secretase subunit. (524 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
NOP53NOP53 ribosome biogenesis factor. (549 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
LOC111775628Uncharacterized protein; Belongs to the peptidase C1 family. (428 aa)
SH3D19SH3 domain containing 19. (1072 aa)
WDR20WD repeat domain 20. (627 aa)
DNAJB2DnaJ heat shock protein family (Hsp40) member B2. (325 aa)
BCAP31B cell receptor associated protein 31. (280 aa)
RNF14RBR-type E3 ubiquitin transferase. (467 aa)
DET1DET1 partner of COP1 E3 ubiquitin ligase. (709 aa)
WDR48WD repeat domain 48. (796 aa)
PSME1Proteasome activator subunit 1. (249 aa)
RNF180Ring finger protein 180. (592 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (712 aa)
LOC100061631EF-hand domain-containing protein; Belongs to the S-100 family. (160 aa)
PAWRUncharacterized protein. (596 aa)
HIP1Huntingtin interacting protein 1. (1082 aa)
DISC1DISC1 scaffold protein. (890 aa)
RP1L1Uncharacterized protein. (387 aa)
CCDC22Coiled-coil domain containing 22. (627 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
NUB1Negative regulator of ubiquitin like proteins 1. (640 aa)
LYNTyrosine-protein kinase. (533 aa)
NCSTNNicastrin. (709 aa)
PMAIP1Phorbol-12-myristate-13-acetate-induced protein 1. (54 aa)
CRADDCASP2 and RIPK1 domain containing adaptor with death domain. (233 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
AGBL4ATP/GTP binding protein like 4. (531 aa)
ASPHAspartate beta-hydroxylase. (790 aa)
GPLD1Glycosylphosphatidylinositol specific phospholipase D1. (867 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
HPNHepsin; Belongs to the peptidase S1 family. (513 aa)
CASP8AP2Caspase 8 associated protein 2. (2070 aa)
TMEM259Transmembrane protein 259. (635 aa)
CASP9Caspase 9; Belongs to the peptidase C14A family. (632 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
CCBE1Collagen and calcium binding EGF domains 1. (439 aa)
AIM2Absent in melanoma 2. (352 aa)
ADAM8Uncharacterized protein. (824 aa)
FZR1Fizzy and cell division cycle 20 related 1. (695 aa)
SYKTyrosine-protein kinase. (716 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
MKRN2Makorin ring finger protein 2. (502 aa)
ZYG11BZyg-11 family member B, cell cycle regulator. (760 aa)
STAT3Signal transducer and activator of transcription. (770 aa)
CTSHUncharacterized protein; Belongs to the peptidase C1 family. (386 aa)
FBXW8F-box and WD repeat domain containing 8. (851 aa)
EFNA3Ephrin RBD domain-containing protein; Belongs to the ephrin family. (436 aa)
NEK5NIMA related kinase 5. (812 aa)
PSME4Proteasome activator subunit 4. (1864 aa)
ZER1Zyg-11 related cell cycle regulator. (766 aa)
PSMC6Proteasome 26S subunit, ATPase 6; Belongs to the AAA ATPase family. (403 aa)
MAPK9Mitogen-activated protein kinase. (446 aa)
PIAS1Protein inhibitor of activated STAT 1. (678 aa)
PSMC4Proteasome 26S subunit, ATPase 4; Belongs to the AAA ATPase family. (526 aa)
DAB2DAB adaptor protein 2. (765 aa)
ENSECAP00000034034Uncharacterized protein. (106 aa)
CYFIP2Cytoplasmic FMR1-interacting protein; Belongs to the CYFIP family. (1278 aa)
ENSECAP00000033783Uncharacterized protein. (78 aa)
SENP1SUMO specific peptidase 1. (691 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
PIDD1P53-induced death domain protein 1. (915 aa)
AGTPBP1ATP/GTP binding protein 1. (1278 aa)
APH1AAph-1 homolog A, gamma-secretase subunit. (274 aa)
SIRT6Sirtuin 6. (407 aa)
CASP2Caspase 2; Belongs to the peptidase C14A family. (452 aa)
IFNGInterferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa)
RNF217RBR-type E3 ubiquitin transferase. (540 aa)
RNF144ARBR-type E3 ubiquitin transferase. (361 aa)
SIRT1Sirtuin 1. (737 aa)
SIRT2Sirtuin 2. (462 aa)
DAPUncharacterized protein. (250 aa)
OSBPL7Oxysterol binding protein like 7. (879 aa)
FIS1Mitochondrial fission 1 protein; Involved in the fragmentation of the mitochondrial network and its perinuclear clustering. (152 aa)
LOC100061598EF-hand domain-containing protein; Belongs to the S-100 family. (162 aa)
BBS7Bardet-Biedl syndrome 7 protein homolog; The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. (715 aa)
PSME3Proteasome activator subunit 3. (265 aa)
ARIH1RBR-type E3 ubiquitin transferase. (554 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
PSMC2Proteasome 26S subunit, ATPase 2; Belongs to the AAA ATPase family. (531 aa)
COP1COP1 E3 ubiquitin ligase. (737 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
CLDN3Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (218 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (753 aa)
AURKAIP1Aurora kinase A interacting protein 1. (199 aa)
RNF144BRBR-type E3 ubiquitin transferase. (304 aa)
ATP2A3Calcium-transporting ATPase; This magnesium-dependent enzyme catalyzes the hydrolysis of ATP coupled with the transport of calcium. (1098 aa)
S100A9EF-hand domain-containing protein; Belongs to the S-100 family. (153 aa)
FOXL2Forkhead box L2. (378 aa)
LOC102148739NACHT domain-containing protein. (1069 aa)
SNX9Sorting nexin. (621 aa)
BBC3BCL2 binding component 3. (261 aa)
CBFA2T3CBFA2/RUNX1 translocation partner 3. (658 aa)
PSMC5Proteasome 26S subunit, ATPase 5; Belongs to the AAA ATPase family. (433 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
TANKTRAF family member associated NFKB activator. (426 aa)
TNFSF15Tumor necrosis factor ligand 1B. (260 aa)
CLEC3BC-type lectin domain family 3 member B. (262 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
MTCH1Mitochondrial carrier 1; Belongs to the mitochondrial carrier (TC 2.A.29) family. (435 aa)
PACSIN3Protein kinase C and casein kinase substrate in neurons 3. (428 aa)
RNF185Ring finger protein 185. (192 aa)
BCL10BCL10 immune signaling adaptor. (374 aa)
CCN1Cellular communication network factor 1. (382 aa)
GSK3BGlycogen synthase kinase 3 beta; Belongs to the protein kinase superfamily. (440 aa)
PSMC3Proteasome 26S subunit, ATPase 3; Belongs to the AAA ATPase family. (423 aa)
RAD23ARAD23 homolog A, nucleotide excision repair protein. (363 aa)
SH3RF2SH3 domain containing ring finger 2. (732 aa)
CASP10Caspase 10; Belongs to the peptidase C14A family. (478 aa)
OGTO-linked N-acetylglucosamine (GlcNAc) transferase. (1046 aa)
BAK1BCL2 antagonist/killer 1. (211 aa)
AXIN1Axin 1. (939 aa)
USP50Ubiquitin specific peptidase 50; Belongs to the peptidase C19 family. (333 aa)
F3Coagulation factor III, tissue factor. (388 aa)
PRELID1PRELI domain containing 1. (219 aa)
LPCAT3Lysophosphatidylcholine acyltransferase 3; Belongs to the membrane-bound acyltransferase family. (486 aa)
IST1IST1 factor associated with ESCRT-III. (363 aa)
GBAGlucosylceramidase. (536 aa)
FBXW7F-box and WD repeat domain containing 7. (754 aa)
RESTRE1 silencing transcription factor. (1039 aa)
RACK1WD_REPEATS_REGION domain-containing protein. (317 aa)
NRDCNardilysin convertase. (1247 aa)
CLUL1Clusterin; Belongs to the clusterin family. (465 aa)
TFAP4Transcription factor AP-4. (338 aa)
MYCMyc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa)
LOC100055155Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (431 aa)
PCOLCEProcollagen C-endopeptidase enhancer. (459 aa)
MYH9Myosin heavy chain 9; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1981 aa)
SH3RF1SH3 domain containing ring finger 1. (886 aa)
CFLARCASP8 and FADD like apoptosis regulator; Belongs to the peptidase C14A family. (510 aa)
FADDFAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (317 aa)
PDCD6Programmed cell death 6. (189 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
DVL1Dishevelled segment polarity protein 1. (700 aa)
SPON1Spondin 1. (807 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (270 aa)
PCOLCE2Procollagen C-endopeptidase enhancer 2. (414 aa)
TMTC3Transmembrane O-mannosyltransferase targeting cadherins 3. (949 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
ZYG11AZyg-11 family member A, cell cycle regulator. (760 aa)
FAM162AFamily with sequence similarity 162 member A. (155 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
DIABLODiablo IAP-binding mitochondrial protein. (237 aa)
ACVR1CReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. (492 aa)
CDC20Cell division cycle 20. (499 aa)
NLRC4NLR family CARD domain containing 4. (1053 aa)
GSK3AProtein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
TRIB1Tribbles pseudokinase 1. (386 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
SH3RF3SH3 domain containing ring finger 3. (879 aa)
S100A10S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
PDCD5Programmed cell death 5. (125 aa)
PRICKLE1Prickle planar cell polarity protein 1. (832 aa)
CNTN2Contactin 2. (1040 aa)
TBC1D10ATBC1 domain family member 10A. (509 aa)
GRNAntimicrobial peptide eNAP-1; Has antimicrobial activity against Gram-negative and Gram- positive bacteria; Belongs to the granulin family. (587 aa)
PSME2Proteasome activator subunit 2. (239 aa)
AXIN2Axin 2. (843 aa)
YJEFN3YjeF N-terminal domain-containing protein. (249 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
PLK1Serine/threonine-protein kinase PLK. (604 aa)
RNFT2Ring finger protein, transmembrane 2. (309 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
NDUFA13NADH:ubiquinone oxidoreductase subunit A13. (144 aa)
NGFRNerve growth factor receptor. (435 aa)
ECSCRUncharacterized protein. (317 aa)
NLRP12NLR family pyrin domain containing 12. (1061 aa)
RNFT1RING-type domain-containing protein. (433 aa)
PRR7Proline rich 7, synaptic. (274 aa)
ACER2Alkaline ceramidase; Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid. (274 aa)
CLN6CLN6 transmembrane ER protein. (371 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
NODALNodal growth differentiation factor. (348 aa)
DMWDDM1 locus, WD repeat containing. (745 aa)
CDC20BCell division cycle 20B. (515 aa)
PDCD2Programmed cell death 2. (344 aa)
BAXBCL2 associated X, apoptosis regulator. (192 aa)
FASLGTumor necrosis factor ligand 1A; Belongs to the tumor necrosis factor family. (283 aa)
UACAUveal autoantigen with coiled-coil domains and ankyrin repeats. (1416 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (448 aa)
CLPXCaseinolytic mitochondrial matrix peptidase chaperone subunit. (633 aa)
RCHY1Ring finger and CHY zinc finger domain containing 1. (261 aa)
ANGPTL8Angiopoietin like 8. (198 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (422 aa)
SNX33Sorting nexin. (574 aa)
NLRP3NLR family pyrin domain containing 3. (1031 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
USP5Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (858 aa)
BADBCL2 associated agonist of cell death. (167 aa)
NUPR1Nuclear protein 1, transcriptional regulator. (82 aa)
STUB1STIP1 homology and U-box containing protein 1. (303 aa)
TNP1Transition protein 1. (55 aa)
CYCSCytochrome c; Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain. (105 aa)
BAG6BCL2 associated athanogene 6. (1073 aa)
EPHA4EPH receptor A4. (949 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
FASFas cell surface death receptor. (365 aa)
MALT1MALT1 paracaspase. (850 aa)
PLGRKTPlasminogen receptor with a C-terminal lysine. (380 aa)
BAG2BCL2 associated athanogene 2. (211 aa)
RNF19BRBR-type E3 ubiquitin transferase. (549 aa)
SRCTyrosine-protein kinase. (551 aa)
DDA1DET1 and DDB1 associated 1. (102 aa)
ATP5IF1ATP synthase inhibitory factor subunit 1. (108 aa)
IFT57Intraflagellar transport 57. (429 aa)
HERPUD1Homocysteine inducible ER protein with ubiquitin like domain 1. (392 aa)
ASTLMetalloendopeptidase. (429 aa)
TNIP1TNFAIP3 interacting protein 1. (723 aa)
ARIH2RBR-type E3 ubiquitin transferase. (491 aa)
LRRK2Leucine rich repeat kinase 2. (2528 aa)
F12Coagulation factor XII. (615 aa)
F7DPV9_HORSEUncharacterized protein. (145 aa)
LGMNLegumain. (433 aa)
ANKIB1RBR-type E3 ubiquitin transferase. (1103 aa)
CIDEBCell death inducing DFFA like effector b. (222 aa)
S100A8Protein S100; Belongs to the S-100 family. (89 aa)
RCN3Reticulocalbin 3. (328 aa)
TRIB2Tribbles pseudokinase 2. (343 aa)
SGTASmall glutamine rich tetratricopeptide repeat containing alpha. (313 aa)
P2RX1P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. (399 aa)
CSNK1DCasein kinase 1 delta; Belongs to the protein kinase superfamily. (428 aa)
PYCARDPYD and CARD domain containing. (195 aa)
TMEM130Transmembrane protein 130. (435 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
TRIM32Tripartite motif containing 32. (653 aa)
RNF139Ring finger protein 139. (665 aa)
NLRP1NLR family pyrin domain containing 1. (1448 aa)
F6WH02_HORSEFIST_C domain-containing protein. (381 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
RNF19ARBR-type E3 ubiquitin transferase. (838 aa)
RHBDD1Rhomboid domain containing 1. (316 aa)
F7CJH7_HORSERING-type domain-containing protein. (433 aa)
PSENENPresenilin enhancer, gamma-secretase subunit. (101 aa)
TRIM67Tripartite motif containing 67. (783 aa)
TTBK1Tau tubulin kinase 1. (1409 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (450 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
MEFVMEFV innate immuity regulator, pyrin. (117 aa)
FBXO22FIST_C domain-containing protein. (404 aa)
BIDBH3-interacting domain death agonist; Counters the protective effect of Bcl-2. (194 aa)
CLDN4Claudin; Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity; Belongs to the claudin family. (209 aa)
USP13Ubiquitin carboxyl-terminal hydrolase; Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. Belongs to the peptidase C19 family. (863 aa)
PMLPromyelocytic leukemia. (881 aa)
CASP8Caspase 8; Belongs to the peptidase C14A family. (464 aa)
EGLN3Egl-9 family hypoxia inducible factor 3. (239 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
SOCS4Suppressor of cytokine signaling 4. (441 aa)
AIFM1Apoptosis inducing factor mitochondria associated 1. (613 aa)
ADRA2AAdrenoceptor alpha 2A. (465 aa)
PSMC1Proteasome 26S subunit, ATPase 1; Belongs to the AAA ATPase family. (440 aa)
FAM122AFamily with sequence similarity 122A. (329 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
NKX3-1NK3 homeobox 1. (240 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
LAPTM5Lysosomal protein transmembrane 5. (288 aa)
HTRA2HtrA serine peptidase 2. (458 aa)
SART3Spliceosome associated factor 3, U4/U6 recycling protein. (962 aa)
TRIB3Tribbles pseudokinase 3. (353 aa)
FGL2Fibrinogen like 2. (479 aa)
BOKBCL2 family apoptosis regulator BOK. (213 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (18%) [HD]