STRINGSTRING
TGFB2 TGFB2 CAPN3 CAPN3 PRKN PRKN COMMD5 COMMD5 PLS1 PLS1 RIMS1 RIMS1 DBNL DBNL N6AMT1 N6AMT1 TGFBR1 TGFBR1 NEDD4L NEDD4L CSNK2A1 CSNK2A1 CAPN9 CAPN9 UNC13A UNC13A ZFPM2 ZFPM2 SPHK1 SPHK1 DISC1 DISC1 GATA6 GATA6 MKKS MKKS LIMK1 LIMK1 ENSECAP00000041588 ENSECAP00000041588 CDKL5 CDKL5 DERL2 DERL2 STAT5A STAT5A HPN HPN DDX3X DDX3X BDNF BDNF GOLGA4 GOLGA4 HDGFL2 HDGFL2 EGFR EGFR LEP LEP STAT5B STAT5B ENSECAP00000034428 ENSECAP00000034428 ENSECAP00000034034 ENSECAP00000034034 GPAM GPAM IGF1 IGF1 EXOSC2 EXOSC2 MTM1 MTM1 WFS1 WFS1 ISLR2 ISLR2 KDM2B KDM2B NOL12 NOL12 SYT17 SYT17 ARX ARX VILL VILL SMO SMO ERBB2 ERBB2 LOC111772111 LOC111772111 TSHR-2 TSHR-2 MEF2C MEF2C ZFYVE27 ZFYVE27 RPTOR RPTOR BBS4 BBS4 NCBP1 NCBP1 CELF1 CELF1 WNT3A WNT3A NTN1 NTN1 BMPR2 BMPR2 EXOSC9 EXOSC9 WNT2 WNT2 SLC6A3 SLC6A3 LGI1 LGI1 TBX2 TBX2 MTPN MTPN INO80 INO80 NOTCH1 NOTCH1 ERBB4 ERBB4 IST1 IST1 RAG2 RAG2 WNT3 WNT3 SFRP1 SFRP1 USP47 USP47 PSMD10 PSMD10 IL7 IL7 POU4F2 POU4F2 BMPR1A BMPR1A PIM1 PIM1 SMAD7 SMAD7 PLAA PLAA ACTN3 ACTN3 MEGF8 MEGF8 NIPBL NIPBL PROX1 PROX1 FGFR1OP FGFR1OP FXN FXN FGF9 FGF9 EZR EZR CXCL16 CXCL16 CIB1 CIB1 TBX20 TBX20 SMURF1 SMURF1 CSF1 CSF1 GHSR GHSR SYT4 SYT4 PEX5 PEX5 TBX5 TBX5 PPIB PPIB SFRP2 SFRP2 SUPV3L1 SUPV3L1 PPM1F PPM1F SYT3 SYT3 CDKN2AIP CDKN2AIP ZNF639 ZNF639 TSHR TSHR GHRHR GHRHR MUL1 MUL1 KLHL22 KLHL22 FGF2 FGF2 TLR9-2 TLR9-2 DLL1 DLL1 MFSD2A MFSD2A RFTN1 RFTN1 YBX3 YBX3 CREB1 CREB1 EXOSC4 EXOSC4 SYT1 SYT1 BRAT1 BRAT1 DDX49 DDX49 EFNA5 EFNA5 F2 F2 EDN1 EDN1 ARMC12 ARMC12 ZPR1 ZPR1 GLI1 GLI1 AGR2 AGR2 SYT2 SYT2 F7DPV9_HORSE F7DPV9_HORSE BBS2 BBS2 VIL1 VIL1 NGF NGF SASH3 SASH3 RASAL1 RASAL1 SEMA4D SEMA4D SLC44A4 SLC44A4 INSR INSR MAP3K13 MAP3K13 POU1F1 POU1F1 TRIM32 TRIM32 GH1 GH1 SRF SRF ZP3 ZP3 CPNE5 CPNE5 YAP1 YAP1 CPNE9 CPNE9 MMP14 MMP14 PPARD PPARD ADAM10 ADAM10 ADNP2 ADNP2 BMP10 BMP10 FN1 FN1 SOX15 SOX15 TRPV2 TRPV2 SFN SFN ISLR ISLR CHD7 CHD7 HLX HLX FAM122A FAM122A MYOD1 MYOD1 UCN UCN OCM2 OCM2 SEMA7A SEMA7A
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
PRKNE3 ubiquitin-protein ligase parkin; Functions within a multiprotein E3 ubiquitin ligase complex, catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins; Belongs to the RBR family. Parkin subfamily. (466 aa)
COMMD5COMM domain containing 5. (222 aa)
PLS1Plastin 1. (658 aa)
RIMS1Regulating synaptic membrane exocytosis 1. (1681 aa)
DBNLDrebrin like. (565 aa)
N6AMT1N-6 adenine-specific DNA methyltransferase 1. (271 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
NEDD4LNEDD4 like E3 ubiquitin protein ligase. (1235 aa)
CSNK2A1Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (464 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (712 aa)
UNC13AUnc-13 homolog A. (1726 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1150 aa)
SPHK1Sphingosine kinase 1. (459 aa)
DISC1DISC1 scaffold protein. (890 aa)
GATA6GATA binding protein 6. (598 aa)
MKKSMcKusick-Kaufman syndrome. (570 aa)
LIMK1LIM domain kinase 1. (789 aa)
ENSECAP00000041588Uncharacterized protein. (152 aa)
CDKL5Cyclin dependent kinase like 5. (1072 aa)
DERL2Derlin; Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome; Belongs to the derlin family. (239 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
HPNHepsin; Belongs to the peptidase S1 family. (513 aa)
DDX3XDEAD-box helicase 3 X-linked; Belongs to the DEAD box helicase family. (685 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
GOLGA4Golgin A4. (2284 aa)
HDGFL2HDGF like 2. (729 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
LEPLeptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
ENSECAP00000034428Uncharacterized protein. (97 aa)
ENSECAP00000034034Uncharacterized protein. (106 aa)
GPAMGlycerol-3-phosphate acyltransferase, mitochondrial. (900 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
EXOSC2Exosome component 2. (342 aa)
MTM1Myotubularin 1. (636 aa)
WFS1Wolframin ER transmembrane glycoprotein. (888 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (763 aa)
KDM2BLysine demethylase 2B. (1265 aa)
NOL12Uncharacterized protein. (215 aa)
SYT17Synaptotagmin 17. (502 aa)
ARXAristaless related homeobox. (558 aa)
VILLVillin like. (857 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
LOC111772111Thyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (698 aa)
TSHR-2Uncharacterized protein. (122 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (412 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1384 aa)
BBS4Bardet-Biedl syndrome 4. (531 aa)
NCBP1Nuclear cap binding protein subunit 1. (793 aa)
CELF1CUGBP Elav-like family member 1. (588 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
NTN1Netrin 1. (604 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
EXOSC9Exosome component 9. (440 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
SLC6A3Transporter; Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. (617 aa)
LGI1Leucine rich glioma inactivated 1. (641 aa)
TBX2T-box transcription factor 2. (755 aa)
MTPNMyotrophin. (118 aa)
INO80INO80 complex ATPase subunit. (1561 aa)
NOTCH1Notch receptor 1. (2581 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
IST1IST1 factor associated with ESCRT-III. (363 aa)
RAG2Recombination activating 2. (527 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
USP47Ubiquitin specific peptidase 47; Belongs to the peptidase C19 family. (1376 aa)
PSMD10Proteasome 26S subunit, non-ATPase 10. (270 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
POU4F2POU domain protein. (406 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PIM1Serine/threonine-protein kinase; Proto-oncogene with serine/threonine kinase activity involved in cell survival and cell proliferation. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PIM subfamily. (313 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
PLAAPhospholipase A2 activating protein. (863 aa)
ACTN3Actinin alpha 3 (gene/pseudogene). (902 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
NIPBLNipped-B protein. (2805 aa)
PROX1Prospero homeobox 1. (737 aa)
FGFR1OPFGFR1 oncogene partner. (399 aa)
FXNFrataxin. (211 aa)
FGF9Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (208 aa)
EZREzrin. (830 aa)
CXCL16C-X-C motif chemokine ligand 16. (247 aa)
CIB1Calcium and integrin binding 1. (191 aa)
TBX20T-box transcription factor 20. (449 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
CSF1Colony stimulating factor 1. (630 aa)
GHSRGrowth hormone secretagogue receptor; Belongs to the G-protein coupled receptor 1 family. (366 aa)
SYT4Synaptotagmin 4. (577 aa)
PEX5Peroxisomal biogenesis factor 5. (661 aa)
TBX5T-box transcription factor 5. (518 aa)
PPIBPeptidyl-prolyl cis-trans isomerase; PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides; Belongs to the cyclophilin-type PPIase family. (216 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
SUPV3L1Suv3 like RNA helicase. (786 aa)
PPM1FProtein phosphatase, Mg2+/Mn2+ dependent 1F. (448 aa)
SYT3Synaptotagmin 3. (591 aa)
CDKN2AIPCDKN2A interacting protein. (580 aa)
ZNF639Zinc finger protein 639. (485 aa)
TSHRThyrotropin receptor; Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily. (465 aa)
GHRHRGrowth hormone releasing hormone receptor; Belongs to the G-protein coupled receptor 2 family. (423 aa)
MUL1Mitochondrial E3 ubiquitin protein ligase 1. (422 aa)
KLHL22Kelch like family member 22. (634 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
TLR9-2Toll-like receptor 9. (349 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
MFSD2AMajor facilitator superfamily domain containing 2A. (529 aa)
RFTN1Raftlin, lipid raft linker 1. (812 aa)
YBX3Y-box binding protein 3. (360 aa)
CREB1cAMP responsive element binding protein 1. (341 aa)
EXOSC4Exosome component 4. (245 aa)
SYT1Synaptotagmin 1. (422 aa)
BRAT1BRCA1 associated ATM activator 1. (823 aa)
DDX49DEAD-box helicase 49; Belongs to the DEAD box helicase family. (483 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
F2Prothrombin; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing; Belongs to the peptidase S1 family. (622 aa)
EDN1Endothelin 1. (202 aa)
ARMC12Armadillo repeat containing 12. (339 aa)
ZPR1ZPR1 zinc finger. (459 aa)
GLI1GLI family zinc finger 1. (1106 aa)
AGR2Anterior gradient 2, protein disulphide isomerase family member. (175 aa)
SYT2Synaptotagmin 2. (419 aa)
F7DPV9_HORSEUncharacterized protein. (145 aa)
BBS2Bardet-Biedl syndrome 2 protein homolog. (721 aa)
VIL1Villin 1. (827 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
RASAL1RAS protein activator like 1. (926 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
SLC44A4Solute carrier family 44 member 4; Belongs to the CTL (choline transporter-like) family. (708 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
POU1F1POU domain protein. (291 aa)
TRIM32Tripartite motif containing 32. (653 aa)
GH1Somatotropin; Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues; Belongs to the somatotropin/prolactin family. (216 aa)
SRFSerum response factor. (512 aa)
ZP3ZP domain-containing protein. (426 aa)
CPNE5Copine 5. (593 aa)
YAP1Yes associated protein 1. (508 aa)
CPNE9Copine family member 9. (553 aa)
MMP14Matrix metallopeptidase 14. (581 aa)
PPARDPeroxisome proliferator activated receptor delta. (441 aa)
ADAM10ADAM metallopeptidase domain 10. (748 aa)
ADNP2ADNP homeobox 2. (1157 aa)
BMP10Bone morphogenetic protein 10. (424 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
SOX15SRY-box 15. (233 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
SFNStratifin; Belongs to the 14-3-3 family. (248 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
HLXH2.0 like homeobox. (487 aa)
FAM122AFamily with sequence similarity 122A. (329 aa)
MYOD1Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
UCNUrocortin. (126 aa)
OCM2Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (664 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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