STRINGSTRING
MTOR MTOR CHD8 CHD8 SF3B1 SF3B1 DDX50 DDX50 ICE1 ICE1 BAZ1B BAZ1B SMARCA5 SMARCA5 ZC3H8 ZC3H8 ERCC6 ERCC6 ELL ELL ICE2 ICE2 RPTOR RPTOR MYBBP1A MYBBP1A AR AR DDX21 DDX21 DEK DEK
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MTORSerine/threonine-protein kinase mTOR; Belongs to the PI3/PI4-kinase family. (2573 aa)
CHD8Chromodomain-helicase-DNA-binding protein 8; DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive [...] (2583 aa)
SF3B1Splicing factor 3b subunit 1. (1337 aa)
DDX50DExD-box helicase 50. (738 aa)
ICE1Interactor of little elongation complex ELL subunit 1. (2271 aa)
BAZ1BBromodomain adjacent to zinc finger domain 1B. (1483 aa)
SMARCA5SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a, member 5. (1105 aa)
ZC3H8Zinc finger CCCH-type containing 8. (306 aa)
ERCC6ERCC excision repair 6, chromatin remodeling factor. (1484 aa)
ELLElongation factor for RNA polymerase II. (729 aa)
ICE2Interactor of little elongation complex ELL subunit 2. (1026 aa)
RPTORRegulatory associated protein of MTOR complex 1. (1384 aa)
MYBBP1AMYB binding protein 1a. (1425 aa)
ARAndrogen receptor. (882 aa)
DDX21DExD-box helicase 21. (785 aa)
DEKDEK proto-oncogene. (375 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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