STRINGSTRING
MFHAS1 MFHAS1 GADD45A GADD45A MBIP MBIP DAB2IP DAB2IP STK3 STK3 XIAP XIAP TRAF4 TRAF4 FGF19 FGF19 PTK2B PTK2B FLT4 FLT4 SH3RF2 SH3RF2 AXIN1 AXIN1 RASSF2 RASSF2 APP APP MMP1 MMP1 SH3RF1 SH3RF1 PLCB1 PLCB1 TRAF6 TRAF6 AGER AGER NOX1 NOX1 ZNF622 ZNF622 EDAR EDAR BIRC7 BIRC7 CARD9 CARD9 SH3RF3 SH3RF3 NOD2 NOD2 CCN2 CCN2 TNFSF11 TNFSF11 NCF1 NCF1 SLAMF1 SLAMF1 LOC100063059 LOC100063059 WNT7B WNT7B TRAF2 TRAF2 LOC111770212 LOC111770212 CD27 CD27 RASGRP1 RASGRP1 RIPK1 RIPK1 PYCARD PYCARD HIPK2 HIPK2 HMGB1 HMGB1 PJA2 PJA2 MAP4K2 MAP4K2 TRAF5 TRAF5 WNT16 WNT16 TRPV4 TRPV4 WNT7A WNT7A ANKRD6 ANKRD6 SERPINF2 SERPINF2 RB1CC1 RB1CC1 TRAF1 TRAF1 TPD52L1 TPD52L1 RAB44 RAB44 F2RL1 F2RL1 MYD88 MYD88 TNF TNF TNFRSF19 TNFRSF19 UNC5CL UNC5CL TRAF3 TRAF3 MAP3K10 MAP3K10 NOD1 NOD1 TAOK3 TAOK3 MAP3K11 MAP3K11 MAPK8IP1 MAPK8IP1 MAP3K5 MAP3K5 LTBR LTBR CRACR2A CRACR2A RIPK2 RIPK2 TLR3 TLR3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1046 aa)
GADD45AGrowth arrest and DNA damage inducible alpha. (165 aa)
MBIPMAP3K12 binding inhibitory protein 1. (344 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
STK3Serine/threonine kinase 3. (574 aa)
XIAPX-linked inhibitor of apoptosis. (494 aa)
TRAF4TNF receptor-associated factor. (470 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
SH3RF2SH3 domain containing ring finger 2. (732 aa)
AXIN1Axin 1. (939 aa)
RASSF2Ras association domain family member 2. (326 aa)
APPAmyloid beta precursor protein. (811 aa)
MMP1Interstitial collagenase. (520 aa)
SH3RF1SH3 domain containing ring finger 1. (886 aa)
PLCB11-phosphatidylinositol 4,5-bisphosphate phosphodiesterase; The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. (1216 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
NOX1NADPH oxidase 1. (565 aa)
ZNF622Zinc finger protein 622. (478 aa)
EDAREctodysplasin A receptor. (480 aa)
BIRC7Baculoviral IAP repeat containing 7. (282 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
SH3RF3SH3 domain containing ring finger 3. (879 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
CCN2Cellular communication network factor 2. (475 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (318 aa)
NCF1Neutrophil cytosolic factor 1. (392 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (338 aa)
LOC100063059SCY domain-containing protein. (131 aa)
WNT7BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (353 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
LOC111770212C-C motif chemokine. (100 aa)
CD27CD27 molecule. (257 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
PYCARDPYD and CARD domain containing. (195 aa)
HIPK2Homeodomain interacting protein kinase 2. (1244 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
PJA2Praja ring finger ubiquitin ligase 2. (709 aa)
MAP4K2Mitogen-activated protein kinase kinase kinase kinase 2; May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. (820 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
WNT16Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (495 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (857 aa)
WNT7AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (379 aa)
ANKRD6Ankyrin repeat domain 6. (797 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
RB1CC1RB1 inducible coiled-coil 1. (1637 aa)
TRAF1TNF receptor-associated factor. (415 aa)
TPD52L1TPD52 like 1. (245 aa)
RAB44RAB44, member RAS oncogene family. (1012 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
TNFRSF19TNF receptor superfamily member 19. (420 aa)
UNC5CLUnc-5 family C-terminal like. (525 aa)
TRAF3TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (568 aa)
MAP3K10Mitogen-activated protein kinase kinase kinase. (931 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
TAOK3TAO kinase 3. (914 aa)
MAP3K11Mitogen-activated protein kinase kinase kinase. (858 aa)
MAPK8IP1Mitogen-activated protein kinase 8 interacting protein 1. (882 aa)
MAP3K5Mitogen-activated protein kinase kinase kinase 5. (1362 aa)
LTBRLymphotoxin beta receptor. (434 aa)
CRACR2ACalcium release activated channel regulator 2A. (728 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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