STRINGSTRING
PDGFRB PDGFRB SMPD3 SMPD3 CSRNP1 CSRNP1 VEGFA VEGFA CSPG4 CSPG4 LOX LOX PLEKHA1 PLEKHA1 ITGB3 ITGB3 PDGFC PDGFC PDGFRL PDGFRL ZFAND5 ZFAND5 TIPARP TIPARP MYO1E MYO1E PTPN11 PTPN11 PTPN1 PTPN1 PDGFB PDGFB TXNIP TXNIP PDGFD PDGFD STON1 STON1 PTPRJ PTPRJ ABL1 ABL1 ENSECAP00000033804 ENSECAP00000033804 SCHIP1 SCHIP1 SGPL1 SGPL1 NRP1 NRP1 IQGAP1 IQGAP1 NR4A3 NR4A3 PDGFA PDGFA PDGFRA PDGFRA LOC111775907 LOC111775907 RAPGEF1 RAPGEF1 LOC111771846 LOC111771846 PLAT PLAT BCAR1 BCAR1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
SMPD3Sphingomyelin phosphodiesterase 3. (658 aa)
CSRNP1Cysteine and serine rich nuclear protein 1. (608 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
CSPG4Chondroitin sulfate proteoglycan 4. (2321 aa)
LOXLysyl oxidase. (481 aa)
PLEKHA1Pleckstrin homology domain containing A1. (438 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
PDGFRLPlatelet derived growth factor receptor like. (375 aa)
ZFAND5Zinc finger AN1-type containing 5. (216 aa)
TIPARPTCDD inducible poly(ADP-ribose) polymerase. (680 aa)
MYO1EMyosin IE; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (1108 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (493 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
TXNIPThioredoxin interacting protein. (391 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
STON1Stonin-1; May be involved in the endocytic machinery. (738 aa)
PTPRJUncharacterized protein. (1267 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
ENSECAP00000033804Uncharacterized protein. (1210 aa)
SCHIP1SCHIP-1 domain-containing protein. (500 aa)
SGPL1Sphingosine-1-phosphate lyase 1. (610 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
IQGAP1IQ motif containing GTPase activating protein 1. (2101 aa)
NR4A3Nuclear receptor subfamily 4 group A member 3. (641 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
LOC111775907Uncharacterized protein. (1211 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
LOC111771846Receptor-type tyrosine-protein phosphatase eta-like. (1211 aa)
PLATPlasminogen activator, tissue type. (615 aa)
BCAR1BCAR1 scaffold protein, Cas family member. (887 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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