(40 nodes) Positive regulation of fibroblast proliferation network (Equus caballus)

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Predicted Interactions

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Your Input:
	DHX9	DExH-box helicase 9. (1284 aa)
	GAS6	Growth arrest specific 6. (646 aa)
	LIG4	DNA ligase. (911 aa)
	PML	Promyelocytic leukemia. (881 aa)
	FN1	Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
	EREG	Epiregulin. (170 aa)
	WNT1	Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
	TGFB1	Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
	FGF10	Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
	CTC1	CST telomere replication complex component 1. (1229 aa)
	NDUFS4	NADH:ubiquinone oxidoreductase subunit S4. (175 aa)
	FOSL2	FOS like 2, AP-1 transcription factor subunit. (326 aa)
	NGFR	Nerve growth factor receptor. (435 aa)
	BRK1	BRICK1 subunit of SCAR/WAVE actin nucleating complex. (75 aa)
	ITGB3	Integrin beta; Belongs to the integrin beta chain family. (784 aa)
	LOC102148742	RING-type domain-containing protein. (341 aa)
	PDGFC	Platelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
	CDKN1A	Cyclin dependent kinase inhibitor 1A. (164 aa)
	ZMIZ1	Zinc finger MIZ-type containing 1. (1204 aa)
	MYC	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes. (442 aa)
	ESR1	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
	E2F1	E2F transcription factor 1. (436 aa)
	JUN	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
	WNT2	Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
	FNDC3B	Fibronectin type III domain containing 3B. (1204 aa)
	PDGFB	Platelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
	LIF	LIF interleukin 6 family cytokine. (203 aa)
	ENSECAP00000027749	Phospholipase A(2). (83 aa)
	CD248	CD248 molecule. (773 aa)
	DDR2	Discoidin domain receptor tyrosine kinase 2. (855 aa)
	IGF1	Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
	PLA2G1B	Phospholipase A2 isoform 2; PA2 catalyzes the calcium-dependent hydrolysis of the 2-acyl groups in 3-sn-phosphoglycerides, this releases glycerophospholipids and arachidonic acid that serve as the precursors of signal molecules; Belongs to the phospholipase A2 family. (151 aa)
	FBRS	Fibrosin. (984 aa)
	CD74	CD74 molecule. (272 aa)
	PDGFA	PDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
	SPHK1	Sphingosine kinase 1. (459 aa)
	PDGFRA	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
	CDK6	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
	WAPL	WAPL cohesin release factor. (1202 aa)
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
CDK6	CDKN1A	ENSECAP00000046715	ENSECAP00000018987	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Cyclin dependent kinase inhibitor 1A.	0.997
CDK6	E2F1	ENSECAP00000046715	ENSECAP00000021291	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	E2F transcription factor 1.	0.820
CDK6	ESR1	ENSECAP00000046715	ENSECAP00000020141	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.557
CDK6	MYC	ENSECAP00000046715	ENSECAP00000019475	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.426
CDK6	WAPL	ENSECAP00000046715	ENSECAP00000048784	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	WAPL cohesin release factor.	0.402
CDKN1A	CDK6	ENSECAP00000018987	ENSECAP00000046715	Cyclin dependent kinase inhibitor 1A.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.997
CDKN1A	E2F1	ENSECAP00000018987	ENSECAP00000021291	Cyclin dependent kinase inhibitor 1A.	E2F transcription factor 1.	0.720
CDKN1A	ESR1	ENSECAP00000018987	ENSECAP00000020141	Cyclin dependent kinase inhibitor 1A.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.573
CDKN1A	JUN	ENSECAP00000018987	ENSECAP00000021482	Cyclin dependent kinase inhibitor 1A.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.510
CDKN1A	MYC	ENSECAP00000018987	ENSECAP00000019475	Cyclin dependent kinase inhibitor 1A.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.525
CDKN1A	PDGFRA	ENSECAP00000018987	ENSECAP00000043405	Cyclin dependent kinase inhibitor 1A.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.401
E2F1	CDK6	ENSECAP00000021291	ENSECAP00000046715	E2F transcription factor 1.	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.820
E2F1	CDKN1A	ENSECAP00000021291	ENSECAP00000018987	E2F transcription factor 1.	Cyclin dependent kinase inhibitor 1A.	0.720
E2F1	ESR1	ENSECAP00000021291	ENSECAP00000020141	E2F transcription factor 1.	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	0.593
E2F1	JUN	ENSECAP00000021291	ENSECAP00000021482	E2F transcription factor 1.	Jun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family.	0.575
E2F1	LOC102148742	ENSECAP00000021291	ENSECAP00000016996	E2F transcription factor 1.	RING-type domain-containing protein.	0.452
E2F1	MYC	ENSECAP00000021291	ENSECAP00000019475	E2F transcription factor 1.	Myc proto-oncogene protein; Transcription factor that binds DNA in a non-specific manner, yet also specifically recognizes the core sequence 5'-CAC[GA]TG-3'. Activates the transcription of growth-related genes.	0.714
EREG	NGFR	ENSECAP00000005626	ENSECAP00000015435	Epiregulin.	Nerve growth factor receptor.	0.659
EREG	PDGFRA	ENSECAP00000005626	ENSECAP00000043405	Epiregulin.	Platelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development.	0.660
ESR1	CDK6	ENSECAP00000020141	ENSECAP00000046715	Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...]	Cyclin dependent kinase 6; Belongs to the protein kinase superfamily.	0.557