STRINGSTRING
LRRTM1 LRRTM1 IL4 IL4 SNAP91 SNAP91 CLU CLU LRRTM2 LRRTM2 NEU3 NEU3 AAK1 AAK1 PICK1 PICK1 CBL CBL ADIPOQ ADIPOQ GREM1 GREM1 ATAD1 ATAD1 HIP1R HIP1R DNAJC6 DNAJC6 OPHN1 OPHN1 FMR1 FMR1 ANKRD13A ANKRD13A NUMB NUMB BICD1 BICD1 SCYL2 SCYL2 HIP1 HIP1 ITGAV ITGAV GSG1 GSG1 ARC ARC APOC3 APOC3 APLN APLN UNC119 UNC119 SYK SYK SMAP1 SMAP1 DAB2 DAB2 LRRC1 LRRC1 PLCG2 PLCG2 BMP2K BMP2K RSPO1 RSPO1 SGIP1 SGIP1 DGKD DGKD WDR92 WDR92 ANKRD13B ANKRD13B APELA APELA LRPAP1 LRPAP1 HFE HFE USH1G USH1G CLUL1 CLUL1 FLOT1 FLOT1 AHI1 AHI1 LDLRAP1 LDLRAP1 ITGB3 ITGB3 WDR54 WDR54 GSG1L GSG1L RABGEF1 RABGEF1 VTN VTN LOC111770212 LOC111770212 F6SJC9_HORSE F6SJC9_HORSE SFRP4 SFRP4 INSR INSR DRD4 DRD4 RIN3 RIN3 VEGFA VEGFA SELE SELE
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRRTM1Leucine rich repeat transmembrane neuronal 1. (522 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
SNAP91Synaptosome associated protein 91. (912 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (450 aa)
LRRTM2Leucine rich repeat transmembrane neuronal 2. (516 aa)
NEU3Neuraminidase 3. (428 aa)
AAK1AP2 associated kinase 1. (965 aa)
PICK1Protein interacting with PRKCA 1. (417 aa)
CBLCbl proto-oncogene. (914 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
ATAD1ATPase family AAA domain containing 1; Belongs to the AAA ATPase family. (361 aa)
HIP1RHuntingtin interacting protein 1 related. (1203 aa)
DNAJC6DnaJ heat shock protein family (Hsp40) member C6. (1005 aa)
OPHN1Oligophrenin 1. (802 aa)
FMR1Fragile X mental retardation 1. (632 aa)
ANKRD13AAnkyrin repeat domain 13A. (609 aa)
NUMBNUMB endocytic adaptor protein. (674 aa)
BICD1BICD cargo adaptor 1. (975 aa)
SCYL2SCY1 like pseudokinase 2. (933 aa)
HIP1Huntingtin interacting protein 1. (1082 aa)
ITGAVFamily with sequence similarity 171 member B; Belongs to the integrin alpha chain family. (1787 aa)
GSG1Germ cell associated 1. (382 aa)
ARCActivity regulated cytoskeleton associated protein. (398 aa)
APOC3Apolipoprotein C-III; Component of triglyceride-rich very low density lipoproteins (VLDL) and high density lipoproteins (HDL) in plasma. Plays a multifaceted role in triglyceride homeostasis. Intracellularly, promotes hepatic very low density lipoprotein 1 (VLDL1) assembly and secretion; extracellularly, attenuates hydrolysis and clearance of triglyceride-rich lipoproteins (TRLs). Impairs the lipolysis of TRLs by inhibiting lipoprotein lipase and the hepatic uptake of TRLs by remnant receptors. Formed of several curved helices connected via semiflexible hinges, so that it can wrap tigh [...] (117 aa)
APLNUncharacterized protein. (186 aa)
UNC119Unc-119 lipid binding chaperone. (242 aa)
SYKTyrosine-protein kinase. (716 aa)
SMAP1Small ArfGAP 1. (469 aa)
DAB2DAB adaptor protein 2. (765 aa)
LRRC1Leucine rich repeat containing 1. (614 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
BMP2KBMP2 inducible kinase. (1137 aa)
RSPO1R-spondin 1. (305 aa)
SGIP1SH3 domain GRB2 like endophilin interacting protein 1. (853 aa)
DGKDDiacylglycerol kinase. (1308 aa)
WDR92Protein phosphatase 3 regulatory subunit B, alpha. (496 aa)
ANKRD13BAnkyrin repeat domain 13B. (746 aa)
APELAUncharacterized protein. (53 aa)
LRPAP1LDL receptor related protein associated protein 1. (608 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (361 aa)
USH1GUSH1 protein network component sans. (461 aa)
CLUL1Clusterin; Belongs to the clusterin family. (465 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
AHI1Uncharacterized protein. (1219 aa)
LDLRAP1Low density lipoprotein receptor adaptor protein 1. (309 aa)
ITGB3Integrin beta; Belongs to the integrin beta chain family. (784 aa)
WDR54WD repeat domain 54. (365 aa)
GSG1LGSG1 like. (329 aa)
RABGEF1RAB guanine nucleotide exchange factor 1. (492 aa)
VTNVitronectin. (478 aa)
LOC111770212C-C motif chemokine. (100 aa)
F6SJC9_HORSEIg-like domain-containing protein. (324 aa)
SFRP4Secreted frizzled related protein 4. (346 aa)
INSRTyrosine-protein kinase receptor. (1382 aa)
DRD4Dopamine receptor D4; Belongs to the G-protein coupled receptor 1 family. (365 aa)
RIN3Ras and Rab interactor 3. (1007 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
SELEE-selectin; Cell-surface glycoprotein having a role in immunoadhesion. Mediates in the adhesion of blood neutrophils in cytokine-activated endothelium through interaction with SELPLG/PSGL1. May have a role in capillary morphogenesis (By similarity). Belongs to the selectin/LECAM family. (617 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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