(62 nodes) Calcium-dependent protein binding network (Equus caballus)

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	LOC100061598	EF-hand domain-containing protein; Belongs to the S-100 family. (162 aa)
	ENSECAP00000034011	S_100 domain-containing protein; Belongs to the S-100 family. (77 aa)
	LOC102149794	Uncharacterized protein. (468 aa)
	MASP1	Mannan binding lectin serine peptidase 1; Belongs to the peptidase S1 family. (736 aa)
	VPS37C	VPS37C subunit of ESCRT-I. (432 aa)
	S100A16	Protein S100; Belongs to the S-100 family. (103 aa)
	CPNE3	Copine 3. (533 aa)
	ANXA6	Annexin. (737 aa)
	ENSECAP00000040766	S_100 domain-containing protein. (94 aa)
	PDCD6IP	Programmed cell death 6 interacting protein. (927 aa)
	S100Z	Protein S100; Belongs to the S-100 family. (102 aa)
	LRP8	LDL receptor related protein 8. (1011 aa)
	LRRC45	Leucine rich repeat containing 45. (695 aa)
	TSG101	Tumor susceptibility 101. (390 aa)
	ANXA7	Annexin. (488 aa)
	NSMF	NMDA receptor synaptonuclear signaling and neuronal migration factor. (534 aa)
	PVALEF	Parvalbumin like EF-hand containing. (126 aa)
	TNNI3	Troponin I, cardiac muscle; Troponin I is the inhibitory subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. (205 aa)
	LRP1	LDL receptor related protein 1. (4567 aa)
	S100A7	Protein S100-A7; Belongs to the S-100 family. (204 aa)
	S100A2	S100 calcium binding protein A2. (223 aa)
	S100A3	S100 calcium binding protein A3. (173 aa)
	S100A4	Protein S100; Belongs to the S-100 family. (101 aa)
	S100A5	Protein S100; Belongs to the S-100 family. (91 aa)
	SPACA9	Sperm acrosome associated 9. (226 aa)
	S100A6	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity). (92 aa)
	VPS37D	VPS37D subunit of ESCRT-I. (251 aa)
	S100A12	Protein S100; Belongs to the S-100 family. (114 aa)
	S100A8	Protein S100; Belongs to the S-100 family. (89 aa)
	SYT2	Synaptotagmin 2. (419 aa)
	VPS37B	VPS37B subunit of ESCRT-I. (286 aa)
	SELP	Selectin P. (829 aa)
	SLC9A1	Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (814 aa)
	ALG2	ALG2 alpha-1,3/1,6-mannosyltransferase. (520 aa)
	S100B	Protein S100; Belongs to the S-100 family. (93 aa)
	SYT1	Synaptotagmin 1. (422 aa)
	SLC24A4	Solute carrier family 24 member 4; Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. (619 aa)
	RBM22	RNA binding motif protein 22. (472 aa)
	LOC100069985	Uncharacterized protein. (456 aa)
	PLSCR3	Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa)
	F6VRB2_HORSE	Uncharacterized protein. (425 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
	S100G	Protein S100-G; Belongs to the S-100 family. (79 aa)
	CRNN	Cornulin. (480 aa)
	STMN2	Stathmin; Belongs to the stathmin family. (179 aa)
	ANXA3	Annexin. (323 aa)
	S100A11	Protein S100; Belongs to the S-100 family. (105 aa)
	S100A10	S100 calcium binding protein A10; Belongs to the S-100 family. (97 aa)
	TNNC2	Troponin C2, fast skeletal type. (169 aa)
	ANXA11	Annexin. (507 aa)
	TNNC1	Troponin C1, slow skeletal and cardiac type. (161 aa)
	PDCD6	Programmed cell death 6. (189 aa)
	PEF1	Penta-EF-hand domain containing 1. (289 aa)
	CABP1	Calcium binding protein 1. (373 aa)
	MASP2	Mannan binding lectin serine peptidase 2; Belongs to the peptidase S1 family. (686 aa)
	S100A1	Protein S100; Belongs to the S-100 family. (94 aa)
	S100A13	S100 calcium binding protein A13; Belongs to the S-100 family. (98 aa)
	S100A14	S100 calcium binding protein A14; Belongs to the S-100 family. (104 aa)
	LOC100061631	EF-hand domain-containing protein; Belongs to the S-100 family. (160 aa)
	S100A9	EF-hand domain-containing protein; Belongs to the S-100 family. (153 aa)
	S100PBP	S100P binding protein. (426 aa)
	VLDLR	Very low density lipoprotein receptor. (1140 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ALG2	PDCD6	ENSECAP00000009703	ENSECAP00000018627	ALG2 alpha-1,3/1,6-mannosyltransferase.	Programmed cell death 6.	0.458
ALG2	PDCD6IP	ENSECAP00000009703	ENSECAP00000039451	ALG2 alpha-1,3/1,6-mannosyltransferase.	Programmed cell death 6 interacting protein.	0.534
ANXA1	ANXA3	ENSECAP00000013992	ENSECAP00000016220	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Annexin.	0.464
ANXA1	S100A10	ENSECAP00000013992	ENSECAP00000016875	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	S100 calcium binding protein A10; Belongs to the S-100 family.	0.965
ANXA1	S100A11	ENSECAP00000013992	ENSECAP00000016586	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Protein S100; Belongs to the S-100 family.	0.975
ANXA1	S100A12	ENSECAP00000013992	ENSECAP00000007652	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Protein S100; Belongs to the S-100 family.	0.492
ANXA1	S100A16	ENSECAP00000013992	ENSECAP00000000463	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Protein S100; Belongs to the S-100 family.	0.470
ANXA1	S100A4	ENSECAP00000013992	ENSECAP00000006194	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Protein S100; Belongs to the S-100 family.	0.815
ANXA1	S100A6	ENSECAP00000013992	ENSECAP00000006408	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).	0.745
ANXA1	TSG101	ENSECAP00000013992	ENSECAP00000004256	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Tumor susceptibility 101.	0.739
ANXA11	ANXA7	ENSECAP00000017433	ENSECAP00000050480	Annexin.	Annexin.	0.913
ANXA11	PDCD6	ENSECAP00000017433	ENSECAP00000018627	Annexin.	Programmed cell death 6.	0.453
ANXA11	PEF1	ENSECAP00000017433	ENSECAP00000018778	Annexin.	Penta-EF-hand domain containing 1.	0.685
ANXA11	S100A10	ENSECAP00000017433	ENSECAP00000016875	Annexin.	S100 calcium binding protein A10; Belongs to the S-100 family.	0.493
ANXA11	S100A6	ENSECAP00000017433	ENSECAP00000006408	Annexin.	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).	0.492
ANXA11	TSG101	ENSECAP00000017433	ENSECAP00000004256	Annexin.	Tumor susceptibility 101.	0.670
ANXA3	ANXA1	ENSECAP00000016220	ENSECAP00000013992	Annexin.	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	0.464
ANXA3	S100A6	ENSECAP00000016220	ENSECAP00000006408	Annexin.	Protein S100-A6; May function as calcium sensor and modulator, contributing to cellular calcium signaling. May function by interacting with other proteins, such as TPR-containing proteins, and indirectly play a role in many physiological processes such as the reorganization of the actin cytoskeleton and in cell motility. Binds 2 calcium ions. Calcium binding is cooperative (By similarity).	0.407
ANXA3	TSG101	ENSECAP00000016220	ENSECAP00000004256	Annexin.	Tumor susceptibility 101.	0.643
ANXA6	TSG101	ENSECAP00000042277	ENSECAP00000004256	Annexin.	Tumor susceptibility 101.	0.655