STRINGSTRING
KITLG KITLG SEMA7A SEMA7A FZD1 FZD1 GREM1 GREM1 BBS12 BBS12 RET RET HOXA7 HOXA7 RDH10 RDH10 SH2B3 SH2B3 FN1 FN1 GBX2 GBX2 SEMA3E SEMA3E HESX1 HESX1 LRP6 LRP6 SEMA3F SEMA3F ALX1 ALX1 SETD6 SETD6 SEMA4A SEMA4A SRF SRF HAND2 HAND2 MED1 MED1 DNMT3L DNMT3L SNAI2 SNAI2 SEMA4D SEMA4D LMBR1L LMBR1L SLC9A1 SLC9A1 EDN1 EDN1 MSX2 MSX2 EFNB1 EFNB1 NANOG NANOG SEMA3D SEMA3D PHOX2B PHOX2B ZIC3 ZIC3 KIT KIT JAG1 JAG1 SEMA3B SEMA3B FGF2 FGF2 PSMD11 PSMD11 MAPK3 MAPK3 SHC4 SHC4 ALDH1A2 ALDH1A2 ELL3 ELL3 ECE2 ECE2 HNF1B HNF1B KLHL12 KLHL12 SEMA4C SEMA4C BATF BATF GPM6A GPM6A XRCC5 XRCC5 SFRP2 SFRP2 FRZB FRZB SEMA6D SEMA6D NRP2 NRP2 TAL1 TAL1 ACVR1 ACVR1 HTR2B HTR2B RADIL RADIL SP7 SP7 MSX1 MSX1 BMPR1A BMPR1A PDCD6 PDCD6 SEMA3C SEMA3C PEF1 PEF1 SFRP1 SFRP1 PUM1 PUM1 EZH2 EZH2 SOX9 SOX9 REST REST SEMA3G SEMA3G SEMA4G SEMA4G PHACTR4 PHACTR4 ESR1 ESR1 SEMA4B SEMA4B ERBB4 ERBB4 PHF5A PHF5A NOTCH1 NOTCH1 EXT1 EXT1 PHF19 PHF19 SOX10 SOX10 TBX2 TBX2 EPCAM EPCAM GSC GSC MYOCD MYOCD HES1 HES1 FOXA1 FOXA1 WNT10A WNT10A TP63 TP63 METTL5 METTL5 OSR1 OSR1 SMAD4 SMAD4 MEF2C MEF2C LIF LIF SMO SMO UFL1 UFL1 RUNX2 RUNX2 MTF2 MTF2 OTUD5 OTUD5 SEMA3A SEMA3A ERCC2 ERCC2 NRTN NRTN NELFB NELFB TP53 TP53 CITED2 CITED2 SOX18 SOX18 MSI2 MSI2 DMRTA2 DMRTA2 NRP1 NRP1 EDNRA EDNRA EDNRB EDNRB GDNF GDNF HOXB4 HOXB4 CDX2 CDX2 PTPRC PTPRC SOX17 SOX17 HMGA2 HMGA2 HOXD4 HOXD4 SEMA6B SEMA6B ANXA6 ANXA6 GATA6 GATA6 JARID2 JARID2 SEMA6A SEMA6A FAM172A FAM172A SEMA5A SEMA5A ZFP36 ZFP36 EPOP EPOP KBTBD8 KBTBD8 SETD2 SETD2 ITGB1 ITGB1 CDK6 CDK6 CORO1C CORO1C SOX8 SOX8 MAPK1 MAPK1 HIF1A HIF1A SEMA4F SEMA4F ZNF281 ZNF281 SEMA5B SEMA5B FOXO4 FOXO4 TGFB2 TGFB2 TBX3 TBX3 TCOF1 TCOF1 SEMA6C SEMA6C
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KITLGProcessed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (664 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
BBS12Bardet-Biedl syndrome 12. (754 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
HOXA7Homeobox A7. (234 aa)
RDH10Retinol dehydrogenase 10; Belongs to the short-chain dehydrogenases/reductases (SDR) family. (341 aa)
SH2B3SH2B adaptor protein 3. (561 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
GBX2Gastrulation brain homeobox 2. (348 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (776 aa)
HESX1HESX homeobox 1. (185 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
ALX1ALX homeobox 1. (326 aa)
SETD6SET domain containing 6, protein lysine methyltransferase. (585 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (797 aa)
SRFSerum response factor. (512 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
DNMT3LPHD-type domain-containing protein. (387 aa)
SNAI2Snail family transcriptional repressor 2. (268 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
LMBR1LLimb development membrane protein 1 like; Belongs to the LIMR family. (489 aa)
SLC9A1Sodium/hydrogen exchanger; Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. (814 aa)
EDN1Endothelin 1. (202 aa)
MSX2Msh homeobox 2. (260 aa)
EFNB1Ephrin B1; Belongs to the ephrin family. (373 aa)
NANOGHomeobox domain-containing protein. (310 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (937 aa)
PHOX2BPaired like homeobox 2B. (310 aa)
ZIC3Zic family member 3. (535 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (752 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
PSMD11Proteasome 26S subunit, non-ATPase 11. (422 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
SHC4SHC adaptor protein 4. (630 aa)
ALDH1A2Aldehyde dehydrogenase 1 family member A2; Belongs to the aldehyde dehydrogenase family. (518 aa)
ELL3Elongation factor for RNA polymerase II 3. (395 aa)
ECE2Endothelin converting enzyme 2. (883 aa)
HNF1BHNF1 homeobox B. (558 aa)
KLHL12Kelch like family member 12. (592 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
BATFBasic leucine zipper ATF-like transcription factor. (125 aa)
GPM6AGlycoprotein M6A. (278 aa)
XRCC5X-ray repair cross complementing 5. (733 aa)
SFRP2Secreted frizzled related protein 2. (294 aa)
FRZBFrizzled related protein. (325 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1082 aa)
NRP2Neuropilin 2. (976 aa)
TAL1TAL bHLH transcription factor 1, erythroid differentiation factor. (331 aa)
ACVR1Serine/threonine-protein kinase receptor; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (509 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
RADILRap associating with DIL domain. (1068 aa)
SP7Sp7 transcription factor. (431 aa)
MSX1Msh homeobox 1. (303 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
PDCD6Programmed cell death 6. (189 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
PEF1Penta-EF-hand domain containing 1. (289 aa)
SFRP1Secreted frizzled related protein 1. (314 aa)
PUM1Pumilio RNA binding family member 1. (1223 aa)
EZH2Enhancer of zeste 2 polycomb repressive complex 2 subunit. (751 aa)
SOX9SRY-box 9. (509 aa)
RESTRE1 silencing transcription factor. (1039 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
PHACTR4Phosphatase and actin regulator. (744 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
PHF5APHD finger-like domain-containing protein 5-like protein. (110 aa)
NOTCH1Notch receptor 1. (2581 aa)
EXT1Exostosin glycosyltransferase 1; Belongs to the glycosyltransferase 47 family. (746 aa)
PHF19PHD finger protein 19. (599 aa)
SOX10SRY-box transcription factor 10. (546 aa)
TBX2T-box transcription factor 2. (755 aa)
EPCAMEpithelial cell adhesion molecule. (311 aa)
GSCGoosecoid homeobox. (256 aa)
MYOCDMyocardin. (987 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
FOXA1Forkhead box A1. (504 aa)
WNT10AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (417 aa)
TP63Tumor protein 63 (p63); Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes. (680 aa)
METTL5Methyltransferase like 5. (209 aa)
OSR1Odd-skipped related transcription factor 1. (279 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
UFL1UFM1 specific ligase 1. (791 aa)
RUNX2Runt-related transcription factor 2; Transcription factor involved in osteoblastic differentiation and skeletal morphogenesis. Essential for the maturation of osteoblasts and both intramembranous and endochondral ossification. CBF binds to the core site, 5'-PYGPYGGT-3', of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers, osteocalcin, osteopontin, bone sialoprotein, alpha 1(I) collagen, LCK, IL-3 and GM-CSF promoters. Inhibits KAT6B-dependent transcriptional activation. In osteoblasts, supports transcription activati [...] (634 aa)
MTF2Metal response element binding transcription factor 2. (613 aa)
OTUD5OTU deubiquitinase 5. (611 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
ERCC2ERCC excision repair 2, TFIIH core complex helicase subunit. (769 aa)
NRTNNeurturin. (197 aa)
NELFBNegative elongation factor complex member B. (627 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (294 aa)
SOX18SRY-box transcription factor 18. (383 aa)
MSI2Musashi RNA binding protein 2. (392 aa)
DMRTA2DMRT like family A2. (536 aa)
NRP1Neuropilin; Belongs to the neuropilin family. (923 aa)
EDNRAEndothelin receptor type A; Belongs to the G-protein coupled receptor 1 family. (427 aa)
EDNRBEndothelin receptor type B; Non-specific receptor for endothelin 1, 2, and 3. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. (447 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
HOXB4Homeobox B4. (251 aa)
CDX2Caudal type homeobox 2. (315 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
SOX17SRY-box transcription factor 17. (406 aa)
HMGA2Uncharacterized protein. (156 aa)
HOXD4Homeobox D4. (257 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (993 aa)
ANXA6Annexin. (737 aa)
GATA6GATA binding protein 6. (598 aa)
JARID2Jumonji and AT-rich interaction domain containing 2. (1447 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
FAM172AFamily with sequence similarity 172 member A. (496 aa)
SEMA5ASemaphorin 5A. (1079 aa)
ZFP36Uncharacterized protein. (662 aa)
EPOPElongin BC and polycomb repressive complex 2 associated protein. (379 aa)
KBTBD8Kelch repeat and BTB domain containing 8. (681 aa)
SETD2SET domain containing 2, histone lysine methyltransferase. (2563 aa)
ITGB1Integrin beta; Belongs to the integrin beta chain family. (808 aa)
CDK6Cyclin dependent kinase 6; Belongs to the protein kinase superfamily. (403 aa)
CORO1CCoronin; Belongs to the WD repeat coronin family. (525 aa)
SOX8SRY-box 8. (460 aa)
MAPK1Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa)
HIF1AHypoxia inducible factor 1 subunit alpha. (844 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
ZNF281Zinc finger protein 281. (938 aa)
SEMA5BSemaphorin 5B. (1140 aa)
FOXO4Forkhead box O4. (529 aa)
TGFB2Transforming growth factor beta; Belongs to the TGF-beta family. (442 aa)
TBX3T-box transcription factor 3. (745 aa)
TCOF1Treacle ribosome biogenesis factor 1. (1616 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (966 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (20%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.