11 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
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Known Interactions

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Predicted Interactions

gene neighborhood

gene fusions

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Others

textmining

co-expression

protein homology

Your Input:
	ENSECAP00000036381	TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
	TLR1	Toll-like receptor. (756 aa)
	TLR10	Toll like receptor 10; Belongs to the Toll-like receptor family. (811 aa)
	TLR2	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
	IL1RAPL1	Interleukin 1 receptor accessory protein like 1. (696 aa)
	TLR4	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa)
	IL1RAPL2	Interleukin 1 receptor accessory protein like 2. (686 aa)
	TLR6	Toll-like receptor. (859 aa)
	SARM1	Sterile alpha and TIR motif containing 1. (877 aa)
	BST1	Bone marrow stromal cell antigen 1. (383 aa)
	LOC111771935	Toll-like receptor 4. (843 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
BST1	SARM1	ENSECAP00000037290	ENSECAP00000046668	Bone marrow stromal cell antigen 1.	Sterile alpha and TIR motif containing 1.	0.762
ENSECAP00000036381	LOC111771935	ENSECAP00000036381	ENSECAP00000033420	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 4.	0.658
ENSECAP00000036381	TLR1	ENSECAP00000036381	ENSECAP00000026625	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.913
ENSECAP00000036381	TLR4	ENSECAP00000036381	ENSECAP00000008292	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.658
ENSECAP00000036381	TLR6	ENSECAP00000036381	ENSECAP00000001398	TIR domain-containing protein; Belongs to the Toll-like receptor family.	Toll-like receptor.	0.656
LOC111771935	ENSECAP00000036381	ENSECAP00000033420	ENSECAP00000036381	Toll-like receptor 4.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.658
LOC111771935	SARM1	ENSECAP00000033420	ENSECAP00000046668	Toll-like receptor 4.	Sterile alpha and TIR motif containing 1.	0.458
LOC111771935	TLR1	ENSECAP00000033420	ENSECAP00000026625	Toll-like receptor 4.	Toll-like receptor.	0.776
LOC111771935	TLR10	ENSECAP00000033420	ENSECAP00000018320	Toll-like receptor 4.	Toll like receptor 10; Belongs to the Toll-like receptor family.	0.625
LOC111771935	TLR2	ENSECAP00000033420	ENSECAP00000015544	Toll-like receptor 4.	Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...]	0.873
LOC111771935	TLR4	ENSECAP00000033420	ENSECAP00000008292	Toll-like receptor 4.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.824
LOC111771935	TLR6	ENSECAP00000033420	ENSECAP00000001398	Toll-like receptor 4.	Toll-like receptor.	0.992
SARM1	BST1	ENSECAP00000046668	ENSECAP00000037290	Sterile alpha and TIR motif containing 1.	Bone marrow stromal cell antigen 1.	0.762
SARM1	LOC111771935	ENSECAP00000046668	ENSECAP00000033420	Sterile alpha and TIR motif containing 1.	Toll-like receptor 4.	0.458
SARM1	TLR1	ENSECAP00000046668	ENSECAP00000026625	Sterile alpha and TIR motif containing 1.	Toll-like receptor.	0.459
SARM1	TLR4	ENSECAP00000046668	ENSECAP00000008292	Sterile alpha and TIR motif containing 1.	Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...]	0.458
SARM1	TLR6	ENSECAP00000046668	ENSECAP00000001398	Sterile alpha and TIR motif containing 1.	Toll-like receptor.	0.458
TLR1	ENSECAP00000036381	ENSECAP00000026625	ENSECAP00000036381	Toll-like receptor.	TIR domain-containing protein; Belongs to the Toll-like receptor family.	0.913
TLR1	LOC111771935	ENSECAP00000026625	ENSECAP00000033420	Toll-like receptor.	Toll-like receptor 4.	0.776
TLR1	SARM1	ENSECAP00000026625	ENSECAP00000046668	Toll-like receptor.	Sterile alpha and TIR motif containing 1.	0.459