STRINGSTRING
SEMA7A SEMA7A OCM2 OCM2 SRPK3 SRPK3 AMIGO1 AMIGO1 ISLR ISLR RET RET PKHD1L1 PKHD1L1 RTN4R RTN4R MAP6 MAP6 PLXNA2 PLXNA2 TRPV2 TRPV2 FN1 FN1 SEMA3E SEMA3E EFNB3 EFNB3 SEMA3F SEMA3F SEMA4A SEMA4A SRF SRF MAP3K13 MAP3K13 THY1 THY1 CHODL CHODL SEMA4D SEMA4D CDH2 CDH2 NGF NGF F7DPV9_HORSE F7DPV9_HORSE KEL KEL EPHB3 EPHB3 RTN4 RTN4 EFNA5 EFNA5 SPART SPART SEMA3D SEMA3D PLXNA4 PLXNA4 SEMA3B SEMA3B EPHA4 EPHA4 TLR9-2 TLR9-2 STK11 STK11 MT3 MT3 LAYN LAYN SEMA4C SEMA4C ULK1 ULK1 SEMA6D SEMA6D STK25 STK25 CDKL3 CDKL3 FSTL4 FSTL4 PAK1 PAK1 CNTN2 CNTN2 DIP2B DIP2B TNR TNR MEGF8 MEGF8 PAK2 PAK2 POU4F2 POU4F2 SEMA3C SEMA3C EFNA1 EFNA1 WNT3 WNT3 LRRC4C LRRC4C SEMA3G SEMA3G SEMA4G SEMA4G DRAXIN DRAXIN SEMA4B SEMA4B NEFL NEFL IST1 IST1 LRP4 LRP4 CDK5 CDK5 SIPA1L1 SIPA1L1 BMPR2 BMPR2 NTN1 NTN1 WNT3A WNT3A DISC1 DISC1 METRN METRN ZFYVE27 ZFYVE27 PLXNC1 PLXNC1 PLXNA3 PLXNA3 BRAF BRAF TIAM2 TIAM2 PLXND1 PLXND1 SEMA3A SEMA3A ISLR2 ISLR2 RUFY3 RUFY3 ENSECAP00000034034 ENSECAP00000034034 GOLGA4 GOLGA4 BDNF BDNF GDI1 GDI1 METRNL METRNL RYK RYK CDKL5 CDKL5 ARHGAP35 ARHGAP35 PAK3 PAK3 SEMA6B SEMA6B LIMK1 LIMK1 SYNGAP1 SYNGAP1 PLXNB2 PLXNB2 SEMA6A SEMA6A SEMA5A SEMA5A IFRD2 IFRD2 UST UST DBNL DBNL CDH4 CDH4 SEMA4F SEMA4F SEMA5B SEMA5B PLXNB1 PLXNB1 PTPRS PTPRS SEMA6C SEMA6C PLXNA1 PLXNA1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (664 aa)
OCM2Uncharacterized protein; Belongs to the parvalbumin family. (109 aa)
SRPK3Plexin B3. (1946 aa)
AMIGO1Adhesion molecule with Ig like domain 1. (493 aa)
ISLRImmunoglobulin superfamily containing leucine rich repeat. (428 aa)
RETProto-oncogene tyrosine-protein kinase receptor Ret; Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. (1113 aa)
PKHD1L1PKHD1 like 1. (4249 aa)
RTN4RReticulon 4 receptor. (473 aa)
MAP6Microtubule associated protein 6. (1118 aa)
PLXNA2Plexin A2. (1922 aa)
TRPV2Transient receptor potential cation channel subfamily V member 2; Belongs to the transient receptor (TC 1.A.4) family. (766 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
SEMA3ESemaphorin 3E; Belongs to the semaphorin family. (776 aa)
EFNB3Ephrin B3; Belongs to the ephrin family. (340 aa)
SEMA3FSemaphorin 3F; Belongs to the semaphorin family. (785 aa)
SEMA4ASemaphorin 4A; Belongs to the semaphorin family. (797 aa)
SRFSerum response factor. (512 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
THY1Thy-1 cell surface antigen. (161 aa)
CHODLChondrolectin. (273 aa)
SEMA4DSemaphorin 4D; Belongs to the semaphorin family. (862 aa)
CDH2Cadherin 2; Cadherins are calcium-dependent cell adhesion proteins. (906 aa)
NGFNerve growth factor; Belongs to the NGF-beta family. (294 aa)
F7DPV9_HORSEUncharacterized protein. (145 aa)
KELKell metallo-endopeptidase. (768 aa)
EPHB3EPH receptor B3. (1000 aa)
RTN4Reticulon. (1196 aa)
EFNA5Ephrin A5; Belongs to the ephrin family. (228 aa)
SPARTSpartin. (667 aa)
SEMA3DSemaphorin 3D; Belongs to the semaphorin family. (937 aa)
PLXNA4Plexin A4. (1893 aa)
SEMA3BSemaphorin 3B; Belongs to the semaphorin family. (752 aa)
EPHA4EPH receptor A4. (949 aa)
TLR9-2Toll-like receptor 9. (349 aa)
STK11Serine/threonine kinase 11; Belongs to the protein kinase superfamily. (438 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
LAYNLayilin. (374 aa)
SEMA4CSemaphorin 4C; Belongs to the semaphorin family. (1000 aa)
ULK1Unc-51 like autophagy activating kinase 1. (1059 aa)
SEMA6DSemaphorin 6D; Belongs to the semaphorin family. (1082 aa)
STK25Serine/threonine kinase 25. (426 aa)
CDKL3Serine/threonine-protein phosphatase. (848 aa)
FSTL4Follistatin like 4. (842 aa)
PAK1Non-specific serine/threonine protein kinase. (544 aa)
CNTN2Contactin 2. (1040 aa)
DIP2BDisco interacting protein 2 homolog B. (1661 aa)
TNRTenascin R. (1358 aa)
MEGF8Multiple EGF like domains 8. (2789 aa)
PAK2Non-specific serine/threonine protein kinase. (524 aa)
POU4F2POU domain protein. (406 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
EFNA1Ephrin A1; Belongs to the ephrin family. (317 aa)
WNT3Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (475 aa)
LRRC4CLeucine rich repeat containing 4C. (640 aa)
SEMA3GSemaphorin 3G; Belongs to the semaphorin family. (770 aa)
SEMA4GSemaphorin 4G; Belongs to the semaphorin family. (844 aa)
DRAXINDorsal inhibitory axon guidance protein. (344 aa)
SEMA4BSemaphorin 4B; Belongs to the semaphorin family. (826 aa)
NEFLNeurofilament light; Belongs to the intermediate filament family. (572 aa)
IST1IST1 factor associated with ESCRT-III. (363 aa)
LRP4LDL receptor related protein 4. (1905 aa)
CDK5Cyclin dependent kinase 5; Belongs to the protein kinase superfamily. (292 aa)
SIPA1L1Signal induced proliferation associated 1 like 1. (1812 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
NTN1Netrin 1. (604 aa)
WNT3AProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (352 aa)
DISC1DISC1 scaffold protein. (890 aa)
METRNUncharacterized protein. (532 aa)
ZFYVE27Zinc finger FYVE-type containing 27. (412 aa)
PLXNC1Plexin C1. (1559 aa)
PLXNA3Plexin A3. (2102 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
TIAM2T cell lymphoma invasion and metastasis 2. (1708 aa)
PLXND1Plexin D1. (2046 aa)
SEMA3ASemaphorin 3A; Belongs to the semaphorin family. (772 aa)
ISLR2Immunoglobulin superfamily containing leucine rich repeat 2. (763 aa)
RUFY3RUN and FYVE domain containing 3. (669 aa)
ENSECAP00000034034Uncharacterized protein. (106 aa)
GOLGA4Golgin A4. (2284 aa)
BDNFBrain-derived neurotrophic factor; Important signaling molecule that activates signaling cascades downstream of NTRK2 (By similarity). During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS. The versatility of BDNF is emphasized by its contribution to a range of adaptive neuronal responses including lo [...] (299 aa)
GDI1Rab GDP dissociation inhibitor; Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP; Belongs to the Rab GDI family. (463 aa)
METRNLMeteorin like, glial cell differentiation regulator. (324 aa)
RYKReceptor like tyrosine kinase. (611 aa)
CDKL5Cyclin dependent kinase like 5. (1072 aa)
ARHGAP35Rho GTPase activating protein 35. (1553 aa)
PAK3P21 (RAC1) activated kinase 3. (580 aa)
SEMA6BSemaphorin 6B; Belongs to the semaphorin family. (993 aa)
LIMK1LIM domain kinase 1. (789 aa)
SYNGAP1Synaptic Ras GTPase activating protein 1. (1349 aa)
PLXNB2Plexin B2. (2217 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
SEMA5ASemaphorin 5A. (1079 aa)
IFRD2Interferon related developmental regulator 2. (504 aa)
USTUronyl 2-sulfotransferase. (460 aa)
DBNLDrebrin like. (565 aa)
CDH4Cadherin 4; Cadherins are calcium-dependent cell adhesion proteins. (917 aa)
SEMA4FSsemaphorin 4F; Belongs to the semaphorin family. (770 aa)
SEMA5BSemaphorin 5B. (1140 aa)
PLXNB1Plexin B1. (2140 aa)
PTPRSProtein tyrosine phosphatase receptor type S. (1948 aa)
SEMA6CSemaphorin 6C; Belongs to the semaphorin family. (966 aa)
PLXNA1Plexin A1. (1911 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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