STRINGSTRING
ENSECAP00000044919 ENSECAP00000044919 LOC100071074 LOC100071074 LYZ LYZ PGLYRP3 PGLYRP3 SSC5D SSC5D CARD9 CARD9 TBK1 TBK1 LOC100066313 LOC100066313 TNFAIP8 TNFAIP8 IL12A IL12A DEFB1 DEFB1 ENSECAP00000025895 ENSECAP00000025895 ENSECAP00000027749 ENSECAP00000027749 NLRP6 NLRP6 CHGA CHGA DEFB119 DEFB119 ENSECAP00000031054 ENSECAP00000031054 LOC100068329 LOC100068329 RIPK2 RIPK2 DEFA35L DEFA35L DEFA36L DEFA36L DEFA22 DEFA22 RNASE1 RNASE1 IL17A IL17A IL18 IL18 ENSECAP00000041523 ENSECAP00000041523 DEFA8 DEFA8 NOD1 NOD1 IL17F IL17F DEFA20 DEFA20 NOD2 NOD2 RNASE13 RNASE13 DEFA5 DEFA5 LOC100061885 LOC100061885 CHGA-2 CHGA-2 RNASE4 RNASE4 DEFB114 DEFB114 DEFA1 DEFA1 PGLYRP4 PGLYRP4 RNASE6 RNASE6 P2RX7 P2RX7 PGLYRP2 PGLYRP2 HMGB2 HMGB2 PYCARD PYCARD LYG2 LYG2 EPHA2 EPHA2 LYG1 LYG1 F6V4F0_HORSE F6V4F0_HORSE FGR FGR LOC100054193 LOC100054193 C5AR1 C5AR1 LOC100072707 LOC100072707 MYD88 MYD88 F6UTM9_HORSE F6UTM9_HORSE TNF TNF DEFB136 DEFB136 RNASE12 RNASE12 RNASE11 RNASE11 RNASE10 RNASE10 MPEG1 MPEG1 LTA LTA IL27RA IL27RA ROMO1 ROMO1 GBP6 GBP6 ZG16 ZG16 DROSHA DROSHA RARRES2 RARRES2 TNFSF8 TNFSF8 GSDMD GSDMD STAB2 STAB2 HAVCR2 HAVCR2 KLRK1 KLRK1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSECAP00000044919Defensin_propep domain-containing protein. (94 aa)
LOC100071074Peptidoglycan-recognition protein; Pattern receptor that binds to murein peptidoglycans (PGN) of Gram-positive bacteria. May kill Gram-positive bacteria by interfering with peptidoglycan biosynthesis. Involved in innate immunity. (193 aa)
LYZLysozyme C, spleen isozyme; Lysozymes have primarily a bacteriolytic function; those in tissues and body fluids are associated with the monocyte-macrophage system and enhance the activity of immunoagents; Belongs to the glycosyl hydrolase 22 family. (148 aa)
PGLYRP3Peptidoglycan recognition protein 3. (341 aa)
SSC5DScavenger receptor cysteine rich family member with 5 domains. (1620 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
TBK1TANK binding kinase 1. (729 aa)
LOC100066313C-type lectin domain-containing protein. (249 aa)
TNFAIP8TNF alpha induced protein 8. (216 aa)
IL12AInterleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa)
DEFB1Defensin beta 1. (68 aa)
ENSECAP00000025895Uncharacterized protein. (95 aa)
ENSECAP00000027749Phospholipase A(2). (83 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
CHGAp-Glu serpinin precursor; [Pancreastatin]: Strongly inhibits glucose induced insulin release from the pancreas. [Serpinin]: Regulates granule biogenesis in endocrine cells by up-regulating the transcription of protease nexin 1 (SERPINE2) via a cAMP-PKA-SP1 pathway. This leads to inhibition of granule protein degradation in the Golgi complex which in turn promotes granule formation. (458 aa)
DEFB119Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (86 aa)
ENSECAP00000031054Uncharacterized protein. (397 aa)
LOC100068329MACPF domain-containing protein. (691 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
DEFA35LDefensin_propep domain-containing protein; Belongs to the alpha-defensin family. (75 aa)
DEFA36LPaneth cell-specific alpha-defensin 36L; Belongs to the alpha-defensin family. (75 aa)
DEFA22Defensin_propep domain-containing protein. (100 aa)
RNASE1Ribonuclease pancreatic; Endonuclease that catalyzes the cleavage of RNA on the 3' side of pyrimidine nucleotides. Acts on single-stranded and double- stranded RNA (By similarity); Belongs to the pancreatic ribonuclease family. (254 aa)
IL17AUncharacterized protein. (155 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSECAP00000041523GB1/RHD3-type G domain-containing protein. (316 aa)
DEFA8Paneth cell-specific alpha-defensin 8. (98 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
IL17FInterleukin 17F. (154 aa)
DEFA20Paneth cell-specific alpha-defensin 23. (100 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
RNASE13Ribonuclease A family member 13 (inactive); Belongs to the pancreatic ribonuclease family. (150 aa)
DEFA5Uncharacterized protein. (98 aa)
LOC100061885GB1/RHD3-type G domain-containing protein. (647 aa)
CHGA-2Chromogranin A. (458 aa)
RNASE4Ribonuclease A family member 4; Belongs to the pancreatic ribonuclease family. (156 aa)
DEFB114Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (67 aa)
DEFA1Alpha-defensin 1; Has broad-spectrum antimicrobial properties. The antimicrobial activity decreases in the present of salt in vitro. Binds anionic phospholipids, which leads to the aggregation of liposomes in vitro. Membrane permeabilization of the target cells is an essential part of the peptide's mode of antimicrobial activity. No hemolytic activity against sheep or horse erythrocytes. Has antibacterial activity against the bacterial horse pathogens Gram-positive R.equi ATCC 33701 P(-) (minimum bactericidal concentration or MBC=5 ug/ml) and R.equi ATCC 33701 P(+) (MBC=5 ug/ml), which [...] (98 aa)
PGLYRP4Peptidoglycan recognition protein 4. (375 aa)
RNASE6Ribonuclease A family member k6; Belongs to the pancreatic ribonuclease family. (154 aa)
P2RX7P2X purinoceptor; Receptor for ATP that acts as a ligand-gated ion channel. Belongs to the P2X receptor family. (595 aa)
PGLYRP2Peptidoglycan recognition protein 2. (517 aa)
HMGB2High mobility group box 2. (210 aa)
PYCARDPYD and CARD domain containing. (195 aa)
LYG2Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (212 aa)
EPHA2EPH receptor A2. (975 aa)
LYG1Lysozyme g-like protein; Belongs to the glycosyl hydrolase 23 family. (196 aa)
F6V4F0_HORSEDEFSN domain-containing protein. (64 aa)
FGRTyrosine-protein kinase. (527 aa)
LOC100054193Histone H2B; Belongs to the histone H2B family. (126 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
LOC100072707RNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (156 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
F6UTM9_HORSERNAse_Pc domain-containing protein; Belongs to the pancreatic ribonuclease family. (159 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
DEFB136Uncharacterized protein. (73 aa)
RNASE12Ribonuclease A I1; Belongs to the pancreatic ribonuclease family. (145 aa)
RNASE11Ribonuclease A family member 11 (inactive); Belongs to the pancreatic ribonuclease family. (199 aa)
RNASE10Inactive ribonuclease-like protein 10; Secreted proximal epididymal protein required for post- testicular sperm maturation and male fertility. May be involved in sperm adhesion to the egg zona pellucida. Does not have ribonuclease activity (By similarity). (213 aa)
MPEG1MACPF domain-containing protein. (717 aa)
LTATumor necrosis factor ligand 1E; Belongs to the tumor necrosis factor family. (204 aa)
IL27RAInterleukin 27 receptor subunit alpha. (650 aa)
ROMO1Reactive oxygen species modulator 1. (79 aa)
GBP6Guanylate binding protein family member 6. (632 aa)
ZG16Zymogen granule protein 16. (165 aa)
DROSHADrosha ribonuclease III. (1374 aa)
RARRES2Retinoic acid receptor responder 2. (163 aa)
TNFSF8Tumor necrosis factor ligand 3A; Belongs to the tumor necrosis factor family. (233 aa)
GSDMDGasdermin D. (485 aa)
STAB2Stabilin 2. (2549 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
KLRK1Killer cell lectin like receptor K1. (232 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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