STRINGSTRING
ENSECAP00000025895 ENSECAP00000025895 SCRIB SCRIB PTPN6 PTPN6 LOC100071927 LOC100071927 ZC3H8 ZC3H8 DLG2 DLG2 LOC100058771 LOC100058771 RC3H1 RC3H1 NCK1 NCK1 PAG1 PAG1 LOC100063866 LOC100063866 GLI3 GLI3 LOC100630393 LOC100630393 PAWR PAWR ENSECAP00000042430 ENSECAP00000042430 RIPOR2 RIPOR2 CD274 CD274 CD86 CD86 PELI1 PELI1 MAD1L1 MAD1L1 CD74 CD74 LOC100053579 LOC100053579 VTCN1 VTCN1 RC3H2 RC3H2 DLG1 DLG1 FOXP3 FOXP3 ZBTB7B ZBTB7B VSIG4 VSIG4 LOC100146250 LOC100146250 LRRC1 LRRC1 ENSECAP00000033220 ENSECAP00000033220 CD80 CD80 NRARP NRARP ENSECAP00000031624 ENSECAP00000031624 PLA2G2D PLA2G2D MARCHF7 MARCHF7 CBLB CBLB CRTAM CRTAM TMEM131L TMEM131L LOC100630386 LOC100630386 ENSECAP00000027821 ENSECAP00000027821 GPNMB GPNMB IDO1 IDO1 SDC4 SDC4 PDCD1LG2 PDCD1LG2 ADORA2A ADORA2A CEBPB CEBPB SOCS1 SOCS1 HFE HFE TSPAN32 TSPAN32 PTPN22 PTPN22 SHH SHH F6W6J0_HORSE F6W6J0_HORSE LOC100072001 LOC100072001 NDFIP1 NDFIP1 LAX1 LAX1 LOC100066399 LOC100066399 PLA2G2F PLA2G2F SMAD7 SMAD7 LRRC32 LRRC32 VSIR VSIR TWSG1 TWSG1 TBX21 TBX21 IRF1 IRF1 LOC100066370 LOC100066370 BMP4 BMP4 TNFRSF21 TNFRSF21 ARG2 ARG2 ITCH ITCH ANXA1 ANXA1 TIGIT TIGIT IL2 IL2 PDE1B PDE1B HAVCR2 HAVCR2 LOC100147151 LOC100147151 CBFB CBFB ILDR2 ILDR2 FOXJ1 FOXJ1 DLG5 DLG5 F6SJC9_HORSE F6SJC9_HORSE F6SD45_HORSE F6SD45_HORSE DUSP3 DUSP3 TGFB1 TGFB1 GLMN GLMN ZC3H12A ZC3H12A HMGB1 HMGB1 IL4 IL4 LOC111767443 LOC111767443 TNFAIP8L2 TNFAIP8L2 FGL1 FGL1 BCL6 BCL6 LOC100066617 LOC100066617 CTLA4 CTLA4 IHH IHH HLX HLX LOXL3 LOXL3 PTPN2 PTPN2 PRKAR1A PRKAR1A FGL2 FGL2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSECAP00000025895Uncharacterized protein. (95 aa)
SCRIBScribble planar cell polarity protein. (1690 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
LOC100071927Galectin. (444 aa)
ZC3H8Zinc finger CCCH-type containing 8. (306 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
LOC100058771Galectin. (383 aa)
RC3H1Ring finger and CCCH-type domains 1. (1131 aa)
NCK1Interleukin 20 receptor subunit beta. (484 aa)
PAG1Phosphoprotein membrane anchor with glycosphingolipid microdomains 1. (434 aa)
LOC100063866AIG1-type G domain-containing protein. (413 aa)
GLI3GLI family zinc finger 3. (1581 aa)
LOC100630393AIG1-type G domain-containing protein. (315 aa)
PAWRUncharacterized protein. (596 aa)
ENSECAP00000042430Ig-like domain-containing protein. (260 aa)
RIPOR2RHO family interacting cell polarization regulator 2. (1224 aa)
CD274CD274 molecule. (301 aa)
CD86CD86 molecule. (335 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (422 aa)
MAD1L1Mitotic arrest deficient 1 like 1. (754 aa)
CD74CD74 molecule. (272 aa)
LOC100053579Ig-like domain-containing protein. (385 aa)
VTCN1V-set domain containing T cell activation inhibitor 1. (282 aa)
RC3H2Ring finger and CCCH-type domains 2. (1121 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
FOXP3Forkhead box P3. (452 aa)
ZBTB7BZinc finger and BTB domain containing 7B. (575 aa)
VSIG4V-set and immunoglobulin domain containing 4. (445 aa)
LOC100146250AIG1-type G domain-containing protein. (315 aa)
LRRC1Leucine rich repeat containing 1. (614 aa)
ENSECAP00000033220AIG1-type G domain-containing protein. (267 aa)
CD80CD80 molecule. (305 aa)
NRARPNOTCH regulated ankyrin repeat protein. (114 aa)
ENSECAP00000031624SH2 domain-containing protein. (436 aa)
PLA2G2DPhospholipase A(2). (145 aa)
MARCHF7Membrane associated ring-CH-type finger 7. (733 aa)
CBLBCbl proto-oncogene B. (1189 aa)
CRTAMCytotoxic and regulatory T cell molecule. (475 aa)
TMEM131LTransmembrane 131 like. (1731 aa)
LOC100630386Uncharacterized protein. (514 aa)
ENSECAP00000027821Galectin. (159 aa)
GPNMBGlycoprotein nmb. (569 aa)
IDO1Indoleamine 2,3-dioxygenase 1. (434 aa)
SDC4Syndecan; Cell surface proteoglycan; Belongs to the syndecan proteoglycan family. (201 aa)
PDCD1LG2Programmed cell death 1 ligand 2. (291 aa)
ADORA2AAdenosine receptor A2a; Receptor for adenosine (By similarity). The activity of this receptor is mediated by G proteins which activate adenylyl cyclase (By similarity). (412 aa)
CEBPBCCAAT/enhancer-binding protein. (347 aa)
SOCS1Suppressor of cytokine signaling 1. (222 aa)
HFEHomeostatic iron regulator; Belongs to the MHC class I family. (361 aa)
TSPAN32Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family. (289 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (830 aa)
SHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa)
F6W6J0_HORSEGalectin. (372 aa)
LOC100072001Galectin. (388 aa)
NDFIP1Nedd4 family interacting protein 1. (221 aa)
LAX1Lymphocyte transmembrane adaptor 1. (445 aa)
LOC100066399Galectin. (139 aa)
PLA2G2FPhospholipase A(2). (210 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
LRRC32Leucine rich repeat containing 32. (745 aa)
VSIRV-set immunoregulatory receptor. (311 aa)
TWSG1Twisted gastrulation BMP signaling modulator 1. (223 aa)
TBX21T-box transcription factor 21. (535 aa)
IRF1Interferon regulatory factor 1. (423 aa)
LOC100066370Galectin. (139 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
TNFRSF21TNF receptor superfamily member 21. (659 aa)
ARG2Arginase. (351 aa)
ITCHE3 ubiquitin-protein ligase. (862 aa)
ANXA1Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
TIGITT cell immunoreceptor with Ig and ITIM domains. (391 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
PDE1BNCK associated protein 1 like. (1182 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
LOC100147151Amine oxidase. (530 aa)
CBFBCore-binding factor subunit beta. (188 aa)
ILDR2Immunoglobulin like domain containing receptor 2. (639 aa)
FOXJ1Forkhead box J1. (421 aa)
DLG5Discs large MAGUK scaffold protein 5; Belongs to the MAGUK family. (1946 aa)
F6SJC9_HORSEIg-like domain-containing protein. (324 aa)
F6SD45_HORSEUncharacterized protein. (106 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
GLMNGlomulin, FKBP associated protein. (597 aa)
ZC3H12AZinc finger CCCH-type containing 12A. (615 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
LOC111767443Cytotoxic and regulatory T cell molecule. (475 aa)
TNFAIP8L2TNF alpha induced protein 8 like 2. (184 aa)
FGL1Fibrinogen like 1. (315 aa)
BCL6BCL6 transcription repressor. (699 aa)
LOC100066617C-type lectin domain-containing protein. (434 aa)
CTLA4Cytotoxic T-lymphocyte associated protein 4. (223 aa)
IHHHedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa)
HLXH2.0 like homeobox. (487 aa)
LOXL3Lysyl oxidase like 3. (796 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
PRKAR1AcAMP-dependent protein kinase type I-alph regulatory subunit-like protein. (378 aa)
FGL2Fibrinogen like 2. (479 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: low (30%) [HD]