STRINGSTRING
ENSECAP00000023817 ENSECAP00000023817 H9GZQ2_HORSE H9GZQ2_HORSE BCL6 BCL6 PCID2 PCID2 MAD2L2 MAD2L2 CARD11 CARD11 CD81 CD81 IL4 IL4 ADA ADA TP53BP1 TP53BP1 MMP14 MMP14 IL10 IL10 STAT6 STAT6 H9GZV0_HORSE H9GZV0_HORSE CLCF1 CLCF1 SASH3 SASH3 AKIRIN2 AKIRIN2 MSH2 MSH2 LOC100052168 LOC100052168 CD27 CD27 TGFB1 TGFB1 CD320 CD320 TLR9 TLR9 BAD BAD PPP2R3C PPP2R3C PDE1B PDE1B IL21 IL21 IL2 IL2 IL6 IL6 CD40 CD40 NOD2 NOD2 TBX21 TBX21 PAXIP1 PAXIP1 ATAD5 ATAD5 NFATC2 NFATC2 LOC102148742 LOC102148742 TNFSF13B TNFSF13B INPP5D INPP5D IL7 IL7 CDKN1A CDKN1A LOC100052108 LOC100052108 MORN5 MORN5 GPR183 GPR183 TFRC TFRC ENSECAP00000023351 ENSECAP00000023351 ENSECAP00000026008 ENSECAP00000026008 MEF2C MEF2C RIF1 RIF1 ENSECAP00000028780 ENSECAP00000028780 EXOSC3 EXOSC3 EXOSC6 EXOSC6 KMT5C KMT5C ENSECAP00000033853 ENSECAP00000033853 SH3KBP1 SH3KBP1 STAT5B STAT5B ENSECAP00000035774 ENSECAP00000035774 SYK SYK BST1 BST1 ENSECAP00000038326 ENSECAP00000038326 PTPRC PTPRC CD74 CD74 STAT5A STAT5A NSD2 NSD2 PELI1 PELI1 TNFRSF13C TNFRSF13C ENSECAP00000041092 ENSECAP00000041092 ENSECAP00000042644 ENSECAP00000042644 SHLD2 SHLD2 IL2RG IL2RG VAV3 VAV3 ENSECAP00000046081 ENSECAP00000046081 TNFSF12 TNFSF12 CD28 CD28 XBP1 XBP1 KMT5B KMT5B
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ENSECAP00000023817Ig-like domain-containing protein. (169 aa)
H9GZQ2_HORSEIg-like domain-containing protein. (170 aa)
BCL6BCL6 transcription repressor. (699 aa)
PCID2PCI domain containing 2. (450 aa)
MAD2L2Mitotic arrest deficient 2 like 2. (233 aa)
CARD11Caspase recruitment domain family member 11. (1156 aa)
CD81Tetraspanin. (393 aa)
IL4Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa)
ADAAdenosine deaminase. (363 aa)
TP53BP1Tumor protein p53 binding protein 1. (1945 aa)
MMP14Matrix metallopeptidase 14. (581 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
STAT6Signal transducer and activator of transcription. (847 aa)
H9GZV0_HORSEUncharacterized protein. (407 aa)
CLCF1Cardiotrophin like cytokine factor 1. (225 aa)
SASH3SAM and SH3 domain containing 3. (380 aa)
AKIRIN2Akirin 2. (411 aa)
MSH2DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa)
LOC100052168Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa)
CD27CD27 molecule. (257 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
CD320CD320 molecule. (267 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
BADBCL2 associated agonist of cell death. (167 aa)
PPP2R3CProtein phosphatase 2 regulatory subunit B''gamma. (453 aa)
PDE1BNCK associated protein 1 like. (1182 aa)
IL21Interleukin; Belongs to the IL-15/IL-21 family. (158 aa)
IL2Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
TBX21T-box transcription factor 21. (535 aa)
PAXIP1PAX interacting protein 1. (1116 aa)
ATAD5ATPase family AAA domain containing 5. (1899 aa)
NFATC2Nuclear factor of activated T cells 2. (915 aa)
LOC102148742RING-type domain-containing protein. (341 aa)
TNFSF13BTumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa)
INPP5DInositol polyphosphate-5-phosphatase D. (1194 aa)
IL7Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa)
CDKN1ACyclin dependent kinase inhibitor 1A. (164 aa)
LOC100052108Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa)
MORN5MORN repeat containing 5. (172 aa)
GPR183G-protein coupled receptor 183-like protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (767 aa)
ENSECAP00000023351Ig-like domain-containing protein. (233 aa)
ENSECAP00000026008Ig-like domain-containing protein. (182 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
RIF1Replication timing regulatory factor 1. (2476 aa)
ENSECAP00000028780Ig-like domain-containing protein. (217 aa)
EXOSC3Exosome component 3. (275 aa)
EXOSC6Exosome component 6. (272 aa)
KMT5CLysine methyltransferase 5C. (626 aa)
ENSECAP00000033853IGv domain-containing protein. (184 aa)
SH3KBP1SH3 domain containing kinase binding protein 1. (711 aa)
STAT5BSignal transducer and activator of transcription. (825 aa)
ENSECAP00000035774Uncharacterized protein. (84 aa)
SYKTyrosine-protein kinase. (716 aa)
BST1Bone marrow stromal cell antigen 1. (383 aa)
ENSECAP00000038326Ig-like domain-containing protein. (173 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
CD74CD74 molecule. (272 aa)
STAT5ASignal transducer and activator of transcription. (800 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1412 aa)
PELI1E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (422 aa)
TNFRSF13CB cell-activating factor receptor. (183 aa)
ENSECAP00000041092Ig-like domain-containing protein. (106 aa)
ENSECAP00000042644Ig-like domain-containing protein. (113 aa)
SHLD2Shieldin complex subunit 2. (1081 aa)
IL2RGFibronectin type-III domain-containing protein. (457 aa)
VAV3Vav guanine nucleotide exchange factor 3. (875 aa)
ENSECAP00000046081Ig-like domain-containing protein. (134 aa)
TNFSF12Uncharacterized protein; Belongs to the tumor necrosis factor family. (432 aa)
CD28CD28 molecule. (228 aa)
XBP1BZIP domain-containing protein. (378 aa)
KMT5BLysine methyltransferase 5B. (877 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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