STRINGSTRING
ROR1 ROR1 PPARGC1A PPARGC1A TCF3 TCF3 ENSECAP00000036607 ENSECAP00000036607 CHUK CHUK LRP5 LRP5 LOC100069440 LOC100069440 ADAM8 ADAM8 AIM2 AIM2 FANK1 FANK1 ENSECAP00000039988 ENSECAP00000039988 CAV1 CAV1 IL18 IL18 ENSECAP00000041316 ENSECAP00000041316 CTH CTH PRKCB PRKCB TRIM27 TRIM27 NOD1 NOD1 CAT CAT SPHK1 SPHK1 CAPN9 CAPN9 TAF12 TAF12 IRAK1 IRAK1 FZD4 FZD4 MAVS MAVS TRAF1 TRAF1 KDM1A KDM1A RBCK1 RBCK1 TRIM25 TRIM25 CD40LG CD40LG ENSECAP00000051121 ENSECAP00000051121 TNFRSF11A TNFRSF11A HIPK2 HIPK2 MAP3K13 MAP3K13 NOLC1 NOLC1 VEGFA VEGFA NFAM1 NFAM1 EP300 EP300 PYCARD PYCARD AR AR RIPK1 RIPK1 DHX33 DHX33 TERF2IP TERF2IP NTS NTS TRIM13 TRIM13 ADGRF1 ADGRF1 EDN1 EDN1 TRIML1 TRIML1 BTNL9 BTNL9 UBE2V1 UBE2V1 MID2 MID2 FLOT2 FLOT2 TRIML2 TRIML2 IRAK2 IRAK2 RGCC RGCC TRAF2 TRAF2 KIT KIT TRADD TRADD MALT1 MALT1 RPS3 RPS3 PRKCH PRKCH RELA RELA COPS5 COPS5 TLR9 TLR9 F7CNV6_HORSE F7CNV6_HORSE ARHGEF2 ARHGEF2 TRIM15 TRIM15 JMY JMY TRIM34 TRIM34 HCLS1 HCLS1 DHX9 DHX9 ABRA ABRA TSSK4 TSSK4 TNFSF11 TNFSF11 IL6 IL6 IL5 IL5 TRIM8 TRIM8 NODAL NODAL TRIM26 TRIM26 PHB2 PHB2 PARK7 PARK7 PRDX3 PRDX3 CD40 CD40 TRIM14 TRIM14 NOD2 NOD2 CRNN CRNN FZD2 FZD2 CIB1 CIB1 ANXA3 ANXA3 NTSR1 NTSR1 CARD9 CARD9 NLRC4 NLRC4 PPARGC1B PPARGC1B ARID5B ARID5B DDRGK1 DDRGK1 DDIT3 DDIT3 SAV1 SAV1 CYTL1 CYTL1 AGER AGER TRAF6 TRAF6 BMP2 BMP2 RELN RELN ARHGEF5 ARHGEF5 TRIM62 TRIM62 APP APP HDAC5 HDAC5 DDX58 DDX58 FLOT1 FLOT1 CLUL1 CLUL1 PSMA6 PSMA6 ESR1 ESR1 CRTC2 CRTC2 RPS6KA5 RPS6KA5 BUD31 BUD31 TRAPPC9 TRAPPC9 MTPN MTPN TRIM38 TRIM38 TFRC TFRC CRTC3 CRTC3 INS INS ADCY8 ADCY8 WNT2 WNT2 PRKD2 PRKD2 ESR2 ESR2 BCL10 BCL10 ADCY1 ADCY1 MYOCD MYOCD IRAK3 IRAK3 EDA EDA FOXA1 FOXA1 TRIM37 TRIM37 RAB7B RAB7B TRIM6 TRIM6 STK3 STK3 TFDP1 TFDP1 IKBKE IKBKE LPAR5 LPAR5 RIPK4 RIPK4 STING1 STING1 STK36 STK36 PRKD1 PRKD1 PRKCI PRKCI CAMK1D CAMK1D MTDH MTDH SMO SMO ZBTB7A ZBTB7A PLPP3 PLPP3 ATF2 ATF2 IKBKB IKBKB ERC1 ERC1 PINK1 PINK1 TRIM32 TRIM32 SRF SRF IL10 IL10 RNF25 RNF25 WNT1 WNT1 RIPK3 RIPK3 CSF3 CSF3 TRIM68 TRIM68 LOC100060051 LOC100060051 SMARCB1 SMARCB1 LRP6 LRP6 CARD14 CARD14 TRIM41 TRIM41 CLU CLU ZC4H2 ZC4H2 CRTC1 CRTC1 CAPN3 CAPN3 LRP8 LRP8 JUP JUP FER FER EIF2AK2 EIF2AK2 IL18RAP IL18RAP RTKN2 RTKN2 MBTPS2 MBTPS2 FZD1 FZD1 NKX3-1 NKX3-1 HSF1 HSF1 TRIM52 TRIM52 TNF TNF MYD88 MYD88 GREM1 GREM1 RHEBL1 RHEBL1 DVL2 DVL2 RNF220 RNF220 IL1RAP IL1RAP TRIM22 TRIM22 THAP11 THAP11 LOC100054534 LOC100054534 TRIM21 TRIM21 CARD11 CARD11 TRAF5 TRAF5 PLCG2 PLCG2 TLR3 TLR3 DDR2 DDR2 WNT10B WNT10B SLCO3A1 SLCO3A1 RIPK2 RIPK2 LTF LTF ANKRD42 ANKRD42 IL18R1 IL18R1 NTRK1 NTRK1 NEUROG1 NEUROG1 PRKCQ PRKCQ PPP3CA PPP3CA
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
ROR1Receptor tyrosine kinase like orphan receptor 1; Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily. (937 aa)
PPARGC1APPARG coactivator 1 alpha. (839 aa)
TCF3Transcription factor 3. (679 aa)
ENSECAP00000036607B30.2/SPRY domain-containing protein. (208 aa)
CHUKComponent of inhibitor of nuclear factor kappa B kinase complex. (745 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
LOC100069440Uncharacterized protein. (298 aa)
ADAM8Uncharacterized protein. (824 aa)
AIM2Absent in melanoma 2. (352 aa)
FANK1Fibronectin type III and ankyrin repeat domains 1. (401 aa)
ENSECAP00000039988Prohibitin. (299 aa)
CAV1Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa)
IL18Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa)
ENSECAP00000041316Uncharacterized protein. (498 aa)
CTHCystathionine gamma-lyase. (409 aa)
PRKCBProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (673 aa)
TRIM27Tripartite motif containing 27. (536 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
CATCatalase. (598 aa)
SPHK1Sphingosine kinase 1. (459 aa)
CAPN9Calpain 9; Belongs to the peptidase C2 family. (712 aa)
TAF12TATA-box binding protein associated factor 12. (322 aa)
IRAK1Interleukin 1 receptor associated kinase 1. (805 aa)
FZD4Frizzled class receptor 4; Belongs to the G-protein coupled receptor Fz/Smo family. (537 aa)
MAVSMitochondrial antiviral signaling protein. (597 aa)
TRAF1TNF receptor-associated factor. (415 aa)
KDM1ALysine demethylase 1A. (1007 aa)
RBCK1RANBP2-type and C3HC4-type zinc finger containing 1. (535 aa)
TRIM25Tripartite motif containing 25. (643 aa)
CD40LGCD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa)
ENSECAP00000051121KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa)
TNFRSF11ATNF receptor superfamily member 11a. (647 aa)
HIPK2Homeodomain interacting protein kinase 2. (1244 aa)
MAP3K13Mitogen-activated protein kinase kinase kinase 13; Activates the JUN N-terminal pathway through activation of the MAP kinase kinase MAP2K7. (966 aa)
NOLC1PPARG related coactivator 1. (1679 aa)
VEGFAVascular endothelial growth factor A; Growth factor active in angiogenesis, vasculogenesis and endothelial cell growth. Induces endothelial cell proliferation, promotes cell migration, inhibits apoptosis and induces permeabilization of blood vessels. Binds to the FLT1/VEGFR1 and KDR/VEGFR2 receptors, heparan sulfate and heparin (By similarity). Binding to NRP1 receptor initiates a signaling pathway needed for motor neuron axon guidance and cell body migration, including for the caudal migration of facial motor neurons from rhombomere 4 to rhombomere 6 during embryonic development (By s [...] (448 aa)
NFAM1NFAT activating protein with ITAM motif 1. (255 aa)
EP300E1A binding protein p300. (2430 aa)
PYCARDPYD and CARD domain containing. (195 aa)
ARAndrogen receptor. (882 aa)
RIPK1Receptor interacting serine/threonine kinase 1. (671 aa)
DHX33DEAH-box helicase 33. (706 aa)
TERF2IPTERF2 interacting protein. (387 aa)
NTSNeurotensin. (170 aa)
TRIM13Tripartite motif containing 13. (409 aa)
ADGRF1Adhesion G protein-coupled receptor F1; Belongs to the G-protein coupled receptor 2 family. (956 aa)
EDN1Endothelin 1. (202 aa)
TRIML1Tripartite motif family like 1. (462 aa)
BTNL9Butyrophilin like 9. (545 aa)
UBE2V1UBIQUITIN_CONJUGAT_2 domain-containing protein. (147 aa)
MID2Midline 2. (735 aa)
FLOT2Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa)
TRIML2Tripartite motif family like 2. (427 aa)
IRAK2Interleukin 1 receptor associated kinase 2. (621 aa)
RGCCRegulator of cell cycle. (155 aa)
TRAF2TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (516 aa)
KITKIT proto-oncogene, receptor tyrosine kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1084 aa)
TRADDTNFRSF1A associated via death domain. (312 aa)
MALT1MALT1 paracaspase. (850 aa)
RPS3Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa)
PRKCHProtein kinase C eta type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that is involved in the regulation of cell differentiation in keratinocytes and pre-B cell receptor, mediates regulation of epithelial tight junction integrity and foam cell formation, and is required for glioblastoma proliferation and apoptosis prevention in MCF-7 cells. In keratinocytes, binds and activates the tyrosine kinase FYN, which in turn blocks epidermal growth factor receptor (EGFR) signaling and leads to keratinocyte growth arrest and differentia [...] (683 aa)
RELARELA proto-oncogene, NF-kB subunit. (551 aa)
COPS5COP9 signalosome complex subunit 5-like protein. (334 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
F7CNV6_HORSEUncharacterized protein. (1071 aa)
ARHGEF2Rho/Rac guanine nucleotide exchange factor 2. (1176 aa)
TRIM15Tripartite motif containing 15. (458 aa)
JMYJunction mediating and regulatory protein, p53 cofactor. (993 aa)
TRIM34Uncharacterized protein. (496 aa)
HCLS1Hematopoietic cell-specific Lyn substrate 1. (498 aa)
DHX9DExH-box helicase 9. (1284 aa)
ABRAActin binding Rho activating protein. (381 aa)
TSSK4Testis specific serine kinase 4. (337 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (318 aa)
IL6Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa)
IL5Interleukin-5; Factor that induces terminal differentiation of late- developing B-cells to immunoglobulin secreting cells. (134 aa)
TRIM8Tripartite motif containing 8. (551 aa)
NODALNodal growth differentiation factor. (348 aa)
TRIM26Tripartite motif containing 26. (539 aa)
PHB2Prohibitin. (299 aa)
PARK7Parkinsonism associated deglycase. (268 aa)
PRDX3Peroxiredoxin 3. (374 aa)
CD40Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa)
TRIM14Tripartite motif containing 14. (440 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
CRNNCornulin. (480 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
CIB1Calcium and integrin binding 1. (191 aa)
ANXA3Annexin. (323 aa)
NTSR1Neurotensin receptor 1; Belongs to the G-protein coupled receptor 1 family. (418 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
NLRC4NLR family CARD domain containing 4. (1053 aa)
PPARGC1BPPARG coactivator 1 beta. (1239 aa)
ARID5BAT-rich interaction domain 5B. (1109 aa)
DDRGK1DDRGK domain containing 1. (315 aa)
DDIT3DNA damage-inducible transcript 3 protein; Multifunctional transcription factor in ER stress response. Plays an essential role in the response to a wide variety of cell stresses and induces cell cycle arrest and apoptosis in response to ER stress. Plays a dual role both as an inhibitor of CCAAT/enhancer- binding protein (C/EBP) function and as an activator of other genes. Acts as a dominant-negative regulator of C/EBP-induced transcription: dimerizes with members of the C/EBP family, impairs their association with C/EBP binding sites in the promoter regions, and inhibits the expression [...] (168 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
CYTL1Cytokine like 1. (136 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
TRAF6TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
RELNReelin. (3460 aa)
ARHGEF5Rho guanine nucleotide exchange factor 5. (1687 aa)
TRIM62Tripartite motif containing 62. (475 aa)
APPAmyloid beta precursor protein. (811 aa)
HDAC5Histone deacetylase; Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. (1117 aa)
DDX58DExD/H-box helicase 58. (1021 aa)
FLOT1Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (427 aa)
CLUL1Clusterin; Belongs to the clusterin family. (465 aa)
PSMA6Proteasome subunit alpha type. (251 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
CRTC2CREB regulated transcription coactivator 2. (684 aa)
RPS6KA5Ribosomal protein S6 kinase. (799 aa)
BUD31BUD31 homolog. (144 aa)
TRAPPC9Trafficking protein particle complex 9. (1180 aa)
MTPNMyotrophin. (118 aa)
TRIM38Tripartite motif containing 38. (464 aa)
TFRCTransferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (767 aa)
CRTC3CREB regulated transcription coactivator 3. (619 aa)
INSInsulin A chain; Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver. (110 aa)
ADCY8Adenylate cyclase type 8; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1252 aa)
WNT2Protein Wnt-2; Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity). (360 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
ESR2Estrogen receptor 2. (550 aa)
BCL10BCL10 immune signaling adaptor. (374 aa)
ADCY1Adenylate cyclase type 1; Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. (1124 aa)
MYOCDMyocardin. (987 aa)
IRAK3Interleukin 1 receptor associated kinase 3. (614 aa)
EDAEctodysplasin A; Belongs to the tumor necrosis factor family. (388 aa)
FOXA1Forkhead box A1. (504 aa)
TRIM37Tripartite motif containing 37. (1093 aa)
RAB7BRAB7B, member RAS oncogene family. (308 aa)
TRIM6Uncharacterized protein. (490 aa)
STK3Serine/threonine kinase 3. (574 aa)
TFDP1Transcription factor. (410 aa)
IKBKEInhibitor of nuclear factor kappa B kinase subunit epsilon. (822 aa)
LPAR5Lysophosphatidic acid receptor 5; Belongs to the G-protein coupled receptor 1 family. (371 aa)
RIPK4Receptor interacting serine/threonine kinase 4. (785 aa)
STING1Transmembrane protein 173. (405 aa)
STK36Serine/threonine kinase 36. (1349 aa)
PRKD1Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (920 aa)
PRKCIProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (655 aa)
CAMK1DCalcium/calmodulin dependent protein kinase ID. (395 aa)
MTDHMetadherin. (615 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
ZBTB7AZinc finger and BTB domain containing 7A. (794 aa)
PLPP3Phospholipid phosphatase 3. (312 aa)
ATF2Activating transcription factor 2. (512 aa)
IKBKBInhibitor of nuclear factor kappa B kinase subunit beta. (770 aa)
ERC1ELKS/RAB6-interacting/CAST family member 1. (1120 aa)
PINK1PTEN induced kinase 1. (585 aa)
TRIM32Tripartite motif containing 32. (653 aa)
SRFSerum response factor. (512 aa)
IL10Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa)
RNF25Ring finger protein 25. (459 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
RIPK3Receptor interacting serine/threonine kinase 3. (513 aa)
CSF3Colony stimulating factor 3. (204 aa)
TRIM68Tripartite motif containing 68. (484 aa)
LOC100060051Uncharacterized protein. (603 aa)
SMARCB1SWI/SNF-related matrix-associated actin-dependent regulator of chromatin subfamily B member 1; Belongs to the SNF5 family. (385 aa)
LRP6Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1613 aa)
CARD14Caspase recruitment domain family member 14. (1003 aa)
TRIM41Tripartite motif containing 41. (631 aa)
CLUClusterin alpha chain; Functions as extracellular chaperone that prevents aggregation of non native proteins. Prevents stress-induced aggregation of blood plasma proteins. Inhibits formation of amyloid fibrils by APP, APOC2, B2M, CALCA, CSN3, SNCA and aggregation-prone LYZ variants (in vitro). Does not require ATP. Maintains partially unfolded proteins in a state appropriate for subsequent refolding by other chaperones, such as HSPA8/HSC70. Does not refold proteins by itself. Binding to cell surface receptors triggers internalization of the chaperone-client complex and subsequent lysos [...] (450 aa)
ZC4H2Zinc finger C4H2-type containing. (272 aa)
CRTC1CREB regulated transcription coactivator 1. (781 aa)
CAPN3Calpain 3; Belongs to the peptidase C2 family. (821 aa)
LRP8LDL receptor related protein 8. (1011 aa)
JUPJunction plakoglobin. (960 aa)
FERTyrosine-protein kinase; Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily. (836 aa)
EIF2AK2Eukaryotic translation initiation factor 2 alpha kinase 2. (540 aa)
IL18RAPInterleukin 18 receptor accessory protein. (600 aa)
RTKN2Rhotekin 2. (608 aa)
MBTPS2Membrane bound transcription factor peptidase, site 2. (531 aa)
FZD1Frizzled class receptor 1; Belongs to the G-protein coupled receptor Fz/Smo family. (595 aa)
NKX3-1NK3 homeobox 1. (240 aa)
HSF1Heat shock transcription factor 1. (535 aa)
TRIM52Tripartite motif containing 52. (286 aa)
TNFTumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa)
MYD88Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
RHEBL1RHEB like 1. (183 aa)
DVL2Dishevelled segment polarity protein 2. (737 aa)
RNF220Ring finger protein 220. (566 aa)
IL1RAPInterleukin 1 receptor accessory protein. (687 aa)
TRIM22Tripartite motif containing 22. (498 aa)
THAP11THAP domain containing 11. (308 aa)
LOC100054534Uncharacterized protein. (511 aa)
TRIM21Tripartite motif containing 21. (469 aa)
CARD11Caspase recruitment domain family member 11. (1156 aa)
TRAF5TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (558 aa)
PLCG2Phosphoinositide phospholipase C. (1331 aa)
TLR3Toll like receptor 3; Belongs to the Toll-like receptor family. (979 aa)
DDR2Discoidin domain receptor tyrosine kinase 2. (855 aa)
WNT10BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa)
SLCO3A1Solute carrier organic anion transporter family member. (710 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
LTFLactotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. The lactotransferrin transferrin-like domain 1 functions as a serine protease of the peptidase S60 family that cuts arginine rich regions. This function contributes to the antimicrobial activity. Shows a preferential cleavage at -Arg-Ser-Arg-Arg-|- and -Arg-Arg-Ser-Arg-|-, and of Z-Phe-Arg-|-aminomethylcoumarin sites. (715 aa)
ANKRD42Ankyrin repeat domain 42. (599 aa)
IL18R1Interleukin 18 receptor 1. (826 aa)
NTRK1Tyrosine-protein kinase receptor. (880 aa)
NEUROG1Neurogenin 1. (347 aa)
PRKCQProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa)
PPP3CASerine/threonine-protein phosphatase. (717 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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