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| | DRB-3 | MHC class II antigen. (266 aa) |
| | DQA | Ig-like domain-containing protein; Belongs to the MHC class II family. (286 aa) |
| | IGF2 | Insulin-like growth factor II; The insulin-like growth factors possess growth-promoting activity. Major fetal growth hormone in mammals. Plays a key role in regulating fetoplacental development. IGF-II is influenced by placental lactogen. Also involved in tissue differentiation. Positively regulates myogenic transcription factor MYOD1 function by facilitating the recruitment of transcriptional coactivators, thereby controlling muscle terminal differentiation. In adults, involved in glucose metabolism in adipose tissue, skeletal muscle and liver. Acts as a ligand for integrin which is r [...] (450 aa) |
| | LOC100053159 | Uncharacterized protein. (491 aa) |
| | HLA-DMA | Major histocompatibility complex, class II, DM alpha; Belongs to the MHC class II family. (314 aa) |
| | TYROBP | TYRO protein tyrosine kinase binding protein. (144 aa) |
| | AIF1 | Allograft inflammatory factor 1. (161 aa) |
| | ENSECAP00000051121 | KH type-2 domain-containing protein; Belongs to the universal ribosomal protein uS3 family. (243 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | CD40LG | CD40 ligand; Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching. (261 aa) |
| | B2M | Beta-2-microglobulin; Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity). (125 aa) |
| | PIK3R5 | Phosphoinositide-3-kinase regulatory subunit 6. (890 aa) |
| | EGR3 | Early growth response 3. (387 aa) |
| | CD28 | CD28 molecule. (228 aa) |
| | TNFSF12 | Uncharacterized protein; Belongs to the tumor necrosis factor family. (432 aa) |
| | LOC100067431 | Uncharacterized protein. (410 aa) |
| | ENSECAP00000046081 | Ig-like domain-containing protein. (134 aa) |
| | FAM49B | Family with sequence similarity 49 member B. (494 aa) |
| | LOC100063866 | AIG1-type G domain-containing protein. (413 aa) |
| | GLI3 | GLI family zinc finger 3. (1581 aa) |
| | LOC100630393 | AIG1-type G domain-containing protein. (315 aa) |
| | VAV3 | Vav guanine nucleotide exchange factor 3. (875 aa) |
| | IL2RG | Fibronectin type-III domain-containing protein. (457 aa) |
| | SHLD2 | Shieldin complex subunit 2. (1081 aa) |
| | LOC100146654 | Ig-like domain-containing protein. (119 aa) |
| | ENSECAP00000042644 | Ig-like domain-containing protein. (113 aa) |
| | CD274 | CD274 molecule. (301 aa) |
| | ENSECAP00000041092 | Ig-like domain-containing protein. (106 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | CAV1 | Caveolin-1; May act as a scaffolding protein within caveolar membranes. Forms a stable heterooligomeric complex with CAV2 that targets to lipid rafts and drives caveolae formation. Mediates the recruitment of CAVIN proteins (CAVIN1/2/3/4) to the caveolae (By similarity). Interacts directly with G-protein alpha subunits and can functionally regulate their activity (By similarity). Involved in the costimulatory signal essential for T-cell receptor (TCR)-mediated T-cell activation. Its binding to DPP4 induces T-cell proliferation and NF-kappa-B activation in a T-cell receptor/CD3-dependen [...] (178 aa) |
| | CD86 | CD86 molecule. (335 aa) |
| | TNFRSF13C | B cell-activating factor receptor. (183 aa) |
| | PELI1 | E3 ubiquitin-protein ligase pellino homolog; E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. (422 aa) |
| | NSD2 | Nuclear receptor binding SET domain protein 2. (1412 aa) |
| | STAT5A | Signal transducer and activator of transcription. (800 aa) |
| | DRB-2 | Ig-like domain-containing protein. (288 aa) |
| | ZBTB16 | Zinc finger and BTB domain containing 16. (673 aa) |
| | LOC100067519 | Uncharacterized protein. (506 aa) |
| | CD74 | CD74 molecule. (272 aa) |
| | LOC100053579 | Ig-like domain-containing protein. (385 aa) |
| | LOC100060806 | Biogenesis of lysosome-related organelles complex 1 subunit 6; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particular [...] (172 aa) |
| | PTPRC | Protein tyrosine phosphatase receptor type C. (1399 aa) |
| | ENSECAP00000038326 | Ig-like domain-containing protein. (173 aa) |
| | LEF1 | Lymphoid enhancer binding factor 1. (413 aa) |
| | ADAM8 | Uncharacterized protein. (824 aa) |
| | VTCN1 | V-set domain containing T cell activation inhibitor 1. (282 aa) |
| | TOX | Thymocyte selection associated high mobility group box. (526 aa) |
| | BST1 | Bone marrow stromal cell antigen 1. (383 aa) |
| | SYK | Tyrosine-protein kinase. (716 aa) |
| | PRKCZ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa) |
| | CD83 | CD83 molecule. (330 aa) |
| | DQB | Ig-like domain-containing protein. (309 aa) |
| | ENSECAP00000036094 | Ig-like domain-containing protein. (142 aa) |
| | ENSECAP00000035774 | Uncharacterized protein. (84 aa) |
| | IGFBP2 | Insulin like growth factor binding protein 2. (326 aa) |
| | DPP4 | Dipeptidyl peptidase 4; Belongs to the peptidase S9B family. (869 aa) |
| | PPP3CA | Serine/threonine-protein phosphatase. (717 aa) |
| | CD5 | CD5 molecule. (496 aa) |
| | LEP | Leptin; Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways (By similarity). In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, inc [...] (189 aa) |
| | FOXP3 | Forkhead box P3. (452 aa) |
| | STAT5B | Signal transducer and activator of transcription. (825 aa) |
| | ZBTB7B | Zinc finger and BTB domain containing 7B. (575 aa) |
| | PRKCQ | Protein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (811 aa) |
| | FCHO1 | FCH domain only 1. (984 aa) |
| | LOC100146250 | AIG1-type G domain-containing protein. (315 aa) |
| | RHOH | Ras homolog family member H. (191 aa) |
| | EPHB6 | EPH receptor B6. (1011 aa) |
| | SH3KBP1 | SH3 domain containing kinase binding protein 1. (711 aa) |
| | ENSECAP00000033853 | IGv domain-containing protein. (184 aa) |
| | TMIGD2 | Transmembrane and immunoglobulin domain containing 2. (325 aa) |
| | GPAM | Glycerol-3-phosphate acyltransferase, mitochondrial. (900 aa) |
| | KMT5C | Lysine methyltransferase 5C. (626 aa) |
| | IGF1 | Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa) |
| | ENSECAP00000033220 | AIG1-type G domain-containing protein. (267 aa) |
| | CD80 | CD80 molecule. (305 aa) |
| | ENSECAP00000032857 | Uncharacterized protein. (46 aa) |
| | WNT10B | Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (389 aa) |
| | AMBRA1 | Autophagy and beclin 1 regulator 1. (1299 aa) |
| | EXOSC6 | Exosome component 6. (272 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | HHLA2 | HERV-H LTR-associating 2. (405 aa) |
| | EXOSC3 | Exosome component 3. (275 aa) |
| | IFNG | Interferon gamma; Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons; Belongs to the type II (or gamma) interferon family. (166 aa) |
| | ITPKB | Kinase; Belongs to the inositol phosphokinase (IPK) family. (1008 aa) |
| | CCDC88B | Coiled-coil domain containing 88B. (1466 aa) |
| | ENSECAP00000028780 | Ig-like domain-containing protein. (217 aa) |
| | RIF1 | Replication timing regulatory factor 1. (2476 aa) |
| | LOC111768185 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa) |
| | NCK2 | Cytoplasmic protein. (380 aa) |
| | KAT5 | Histone acetyltransferase; Belongs to the MYST (SAS/MOZ) family. (546 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | DOCK8 | Dedicator of cytokinesis 8; Belongs to the DOCK family. (2102 aa) |
| | ENSECAP00000026008 | Ig-like domain-containing protein. (182 aa) |
| | ENSECAP00000025895 | Uncharacterized protein. (95 aa) |
| | IL6ST | Interleukin 6 signal transducer. (1023 aa) |
| | IL15 | Interleukin; Belongs to the IL-15/IL-21 family. (432 aa) |
| | LOC102148739 | NACHT domain-containing protein. (1069 aa) |
| | LAMP1 | Lysosomal associated membrane protein 1. (608 aa) |
| | SIRPA | Ig-like domain-containing protein. (584 aa) |
| | DRB | Ig-like domain-containing protein. (275 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (291 aa) |
| | HLA-DOA | Major histocompatibility complex, class II, DO alpha; Belongs to the MHC class II family. (262 aa) |
| | GATA3 | GATA binding protein 3. (445 aa) |
| | ENSECAP00000023817 | Ig-like domain-containing protein. (169 aa) |
| | ENSECAP00000023351 | Ig-like domain-containing protein. (233 aa) |
| | HES1 | Hes family bHLH transcription factor 1. (280 aa) |
| | SOCS1 | Suppressor of cytokine signaling 1. (222 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (374 aa) |
| | CORO1A | Coronin; Belongs to the WD repeat coronin family. (461 aa) |
| | IL12A | Interleukin-12 subunit alpha; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. (256 aa) |
| | FOXO3 | Forkhead box O3. (671 aa) |
| | TFRC | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Positively regulates T and B cell proliferation through iron uptake (By similarity). (767 aa) |
| | PTPN22 | Protein tyrosine phosphatase non-receptor type 22. (830 aa) |
| | ZNF335 | Zinc finger protein 335. (1334 aa) |
| | SART1 | Spliceosome associated factor 1, recruiter of U4/U6.U5 tri-snRNP. (869 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | GPR183 | G-protein coupled receptor 183-like protein; Belongs to the G-protein coupled receptor 1 family. (357 aa) |
| | SHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (461 aa) |
| | MORN5 | MORN repeat containing 5. (172 aa) |
| | TNFSF9 | TNF superfamily member 9; Belongs to the tumor necrosis factor family. (256 aa) |
| | SPTA1 | Spectrin alpha, erythrocytic 1. (2428 aa) |
| | LOC100052108 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa) |
| | IL23A | Interleukin-23 subunit alpha; Associates with IL12B to form the IL-23 interleukin, a heterodimeric cytokine which functions in innate and adaptive immunity. IL-23 may constitute with IL-17 an acute response to infection in peripheral tissues. IL-23 binds to a heterodimeric receptor complex composed of IL12RB1 and IL23R, activates the Jak-Stat signaling cascade, stimulates memory rather than naive T-cells and promotes production of proinflammatory cytokines. IL-23 induces autoimmune inflammation and thus may be responsible for autoimmune inflammatory diseases and may be important for tu [...] (192 aa) |
| | IL12RB1 | Interleukin 12 receptor subunit beta 1. (718 aa) |
| | LOC100060996 | MHC class II antigen. (263 aa) |
| | ZMIZ1 | Zinc finger MIZ-type containing 1. (1204 aa) |
| | CDKN1A | Cyclin dependent kinase inhibitor 1A. (164 aa) |
| | FADD | FAS-associated death domain protein; Apoptotic adaptor molecule that recruits caspase-8 or caspase-10 to the activated Fas (CD95) or TNFR-1 receptors. The resulting aggregate called the death-inducing signaling complex (DISC) performs caspase-8 proteolytic activation. Active caspase-8 initiates the subsequent cascade of caspases mediating apoptosis. Involved in interferon-mediated antiviral immune response, playing a role in the positive regulation of interferon signaling. (212 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | AGER | Advanced glycosylation end-product specific receptor. (403 aa) |
| | LOC100630636 | Ig-like domain-containing protein. (211 aa) |
| | HLA-DOB | MHC class II histocompatibility antigen, DO beta chain. (258 aa) |
| | TYK2 | Tyrosine-protein kinase. (1262 aa) |
| | IL7 | Interleukin-7; Hematopoietic growth factor capable of stimulating the proliferation of lymphoid progenitors. It is important for proliferation during certain stages of B-cell maturation. Belongs to the IL-7/IL-9 family. (176 aa) |
| | IL36B | Interleukin-1. (158 aa) |
| | INPP5D | Inositol polyphosphate-5-phosphatase D. (1194 aa) |
| | TNFSF13B | Tumor necrosis factor superfamily member 13b; Belongs to the tumor necrosis factor family. (290 aa) |
| | LOC102148742 | RING-type domain-containing protein. (341 aa) |
| | NFATC2 | Nuclear factor of activated T cells 2. (915 aa) |
| | ATAD5 | ATPase family AAA domain containing 5. (1899 aa) |
| | VSIR | V-set immunoregulatory receptor. (311 aa) |
| | PAXIP1 | PAX interacting protein 1. (1116 aa) |
| | TBX21 | T-box transcription factor 21. (535 aa) |
| | NLRP12 | NLR family pyrin domain containing 12. (1061 aa) |
| | ZBTB1 | Zinc finger and BTB domain containing 1. (644 aa) |
| | TNFSF14 | Tumor necrosis factor ligand 1D. (241 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | CD40 | Tumor necrosis factor receptor superfamily member 5; Receptor for TNFSF5/CD40LG (By similarity). Transduces TRAF6- and MAP3K8-mediated signals that activate ERK in macrophages and B cells, leading to induction of immunoglobulin secretion (By similarity). (280 aa) |
| | HLA-DQB2 | Ig-like domain-containing protein. (217 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | TNFSF11 | Tumor necrosis factor ligand superfamily member. (318 aa) |
| | ANXA1 | Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa) |
| | SLC7A1 | Solute carrier family 7 member 1. (629 aa) |
| | IL2 | Interleukin-2; Produced by T-cells in response to antigenic or mitogenic stimulation, this protein is required for T-cell proliferation and other activities crucial to regulation of the immune response. Can stimulate B-cells, monocytes, lymphokine-activated killer cells, natural killer cells, and glioma cells; Belongs to the IL-2 family. (149 aa) |
| | IL21 | Interleukin; Belongs to the IL-15/IL-21 family. (158 aa) |
| | PDE1B | NCK associated protein 1 like. (1182 aa) |
| | PPP2R3C | Protein phosphatase 2 regulatory subunit B''gamma. (453 aa) |
| | NLRP3 | NLR family pyrin domain containing 3. (1031 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (280 aa) |
| | LOC100147151 | Amine oxidase. (530 aa) |
| | CBFB | Core-binding factor subunit beta. (188 aa) |
| | BAD | BCL2 associated agonist of cell death. (167 aa) |
| | SLAMF1 | Signaling lymphocytic activation molecule family member 1. (338 aa) |
| | FGF10 | Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa) |
| | PCK1 | Phosphoenolpyruvate carboxykinase 1. (622 aa) |
| | TLR9 | Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa) |
| | RPS3 | Ribosomal protein S3; Belongs to the universal ribosomal protein uS3 family. (281 aa) |
| | CD320 | CD320 molecule. (267 aa) |
| | MALT1 | MALT1 paracaspase. (850 aa) |
| | GAS6 | Growth arrest specific 6. (646 aa) |
| | KITLG | Processed kit ligand; Stimulates the proliferation of mast cells. Able to augment the proliferation of both myeloid and lymphoid hematopoietic progenitors in bone marrow culture. Mediates also cell-cell adhesion. Acts synergistically with other cytokines, probably interleukins (By similarity); Belongs to the SCF family. (303 aa) |
| | SOX12 | Transcription factor SOX. (316 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | H9GZQ2_HORSE | Ig-like domain-containing protein. (170 aa) |
| | HLX | H2.0 like homeobox. (487 aa) |
| | HPS1 | HPS1 biogenesis of lysosomal organelles complex 3 subunit 1. (735 aa) |
| | ZP1 | Zona pellucida glycoprotein 1. (619 aa) |
| | IHH | Hedgehog protein; Intercellular signal essential for a variety of patterning events during development. (410 aa) |
| | CCR7 | C-C motif chemokine receptor 7; Belongs to the G-protein coupled receptor 1 family. (451 aa) |
| | BCL6 | BCL6 transcription repressor. (699 aa) |
| | PCID2 | PCI domain containing 2. (450 aa) |
| | ICOS | Inducible T cell costimulator. (257 aa) |
| | MAD2L2 | Mitotic arrest deficient 2 like 2. (233 aa) |
| | DQA-2 | Ig-like domain-containing protein; Belongs to the MHC class II family. (293 aa) |
| | CARD11 | Caspase recruitment domain family member 11. (1156 aa) |
| | CD81 | Tetraspanin. (393 aa) |
| | LGALS1 | Galectin. (135 aa) |
| | SHB | SH2 domain-containing protein. (787 aa) |
| | EFNB3 | Ephrin B3; Belongs to the ephrin family. (340 aa) |
| | IL4 | Interleukin-4; Participates in at least several B-cell activation processes as well as of other cell types. It is a costimulator of DNA-synthesis. It induces the expression of class II MHC molecules on resting B-cells. It enhances both secretion and cell surface expression of IgE and IgG1. It also regulates the expression of the low affinity Fc receptor for IgE (CD23) on both lymphocytes and monocytes. Positively regulates IL31RA expression in macrophages. Stimulates autophagy in dendritic cells by interfering with mTORC1 signaling and through the induction of RUFY4; Belongs to the IL- [...] (139 aa) |
| | HMGB1 | High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa) |
| | ADA | Adenosine deaminase. (363 aa) |
| | TP53BP1 | Tumor protein p53 binding protein 1. (1945 aa) |
| | MMP14 | Matrix metallopeptidase 14. (581 aa) |
| | ZP3 | ZP domain-containing protein. (426 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa) |
| | STAT6 | Signal transducer and activator of transcription. (847 aa) |
| | HSPD1 | Heat shock protein family D (Hsp60) member 1; Belongs to the chaperonin (HSP60) family. (573 aa) |
| | RASAL3 | RAS protein activator like 3. (1029 aa) |
| | DHPS | Deoxyhypusine synthase. (370 aa) |
| | H9GZV0_HORSE | Uncharacterized protein. (407 aa) |
| | THY1 | Thy-1 cell surface antigen. (161 aa) |
| | CLCF1 | Cardiotrophin like cytokine factor 1. (225 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | DUSP10 | Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa) |
| | SASH3 | SAM and SH3 domain containing 3. (380 aa) |
| | RASGRP1 | RAS guanyl releasing protein 1. (797 aa) |
| | MYB | MYB proto-oncogene, transcription factor. (757 aa) |
| | AKIRIN2 | Akirin 2. (411 aa) |
| | MSH2 | DNA mismatch repair protein; Component of the post-replicative DNA mismatch repair system (MMR). (934 aa) |
| | CD160 | CD160 molecule. (181 aa) |
| | LOC100052168 | Abasic site processing protein HMCES; Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA. The HMCES DNA-protein cross- link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endon [...] (350 aa) |
| | ZP4 | Zona pellucida glycoprotein 4. (476 aa) |
| | CD27 | CD27 molecule. (257 aa) |
| | ZAP70 | Tyrosine-protein kinase. (619 aa) |
| | CD6 | CD6 molecule. (673 aa) |
| | BTNL2 | Butyrophilin like 2. (560 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | NFKBIZ | NFKB inhibitor zeta. (711 aa) |
| | AXL | AXL receptor tyrosine kinase. (887 aa) |
| | IL27RA | Interleukin 27 receptor subunit alpha. (650 aa) |
| | EFNB1 | Ephrin B1; Belongs to the ephrin family. (373 aa) |
| | FLOT2 | Flotillin; Belongs to the band 7/mec-2 family. Flotillin subfamily. (428 aa) |
| | SOX13 | SRY-box 13. (615 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | LOC111770212 | C-C motif chemokine. (100 aa) |
| | KMT5B | Lysine methyltransferase 5B. (877 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa) |
