STRINGSTRING
CASQ2 CASQ2 JPH3 JPH3 CALM1 CALM1 CALML3 CALML3 CLIC2 CLIC2 JSRP1 JSRP1 PLN PLN FKBP1B FKBP1B PKD2 PKD2 SRI SRI TRDN TRDN HRC HRC SELENON SELENON
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CASQ2Calsequestrin; Calsequestrin is a high-capacity, moderate affinity, calcium- binding protein and thus acts as an internal calcium store in muscle. (445 aa)
JPH3Junctophilin; Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels. (754 aa)
CALM1Uncharacterized protein; Belongs to the calmodulin family. (336 aa)
CALML3Calmodulin like 3; Belongs to the calmodulin family. (149 aa)
CLIC2Chloride intracellular channel 2. (247 aa)
JSRP1Junctional sarcoplasmic reticulum protein 1. (334 aa)
PLNCardiac phospholamban; Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN. (52 aa)
FKBP1BPeptidylprolyl isomerase. (223 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
SRISorcin. (216 aa)
TRDNTriadin. (727 aa)
HRCHistidine rich calcium binding protein. (673 aa)
SELENONSelenoprotein N. (563 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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