STRINGSTRING
LRP2 LRP2 GATA6 GATA6 ZFPM2 ZFPM2 NOTCH2 NOTCH2 TGFBR1 TGFBR1 FGF8 FGF8 TBX3 TBX3 SMAD6 SMAD6 DNAH11 DNAH11 SLIT3 SLIT3 HAND1 HAND1 APLNR APLNR CHD7 CHD7 TBX20 TBX20 NRP2 NRP2 GATA4 GATA4 SMAD7 SMAD7 SAV1 SAV1 BMPR1A BMPR1A SEMA3C SEMA3C WNT11 WNT11 NOTCH1 NOTCH1 NKX2-5 NKX2-5 TBX2 TBX2 CCN1 CCN1 BMPR2 BMPR2 HES1 HES1 MKS1 MKS1 SMAD4 SMAD4 SMO SMO TP53 TP53 CITED2 CITED2 AK1 AK1 ZFPM1 ZFPM1 PARVA PARVA NSD2 NSD2 BMP4 BMP4 FZD2 FZD2 TBX5 TBX5 PROX1 PROX1 JAG1 JAG1 DHRS3 DHRS3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LRP2LDL receptor related protein 2. (4673 aa)
GATA6GATA binding protein 6. (598 aa)
ZFPM2Zinc finger protein, FOG family member 2. (1150 aa)
NOTCH2Notch receptor 2. (2471 aa)
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
FGF8Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (244 aa)
TBX3T-box transcription factor 3. (745 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
DNAH11Dynein axonemal heavy chain 11. (4525 aa)
SLIT3Slit guidance ligand 3. (1521 aa)
HAND1Heart and neural crest derivatives expressed 1. (218 aa)
APLNRApelin receptor; Belongs to the G-protein coupled receptor 1 family. (380 aa)
CHD7Chromodomain helicase DNA binding protein 7. (2995 aa)
TBX20T-box transcription factor 20. (449 aa)
NRP2Neuropilin 2. (976 aa)
GATA4GATA binding protein 4. (443 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SAV1Salvador family WW domain containing protein 1. (384 aa)
BMPR1AReceptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (532 aa)
SEMA3CSemaphorin 3C; Belongs to the semaphorin family. (751 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
NOTCH1Notch receptor 1. (2581 aa)
NKX2-5NK2 homeobox 5. (322 aa)
TBX2T-box transcription factor 2. (755 aa)
CCN1Cellular communication network factor 1. (382 aa)
BMPR2Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (1037 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
MKS1MKS transition zone complex subunit 1. (793 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
SMOSmoothened, frizzled class receptor; Belongs to the G-protein coupled receptor Fz/Smo family. (788 aa)
TP53Cellular tumor antigen p53; Acts as a tumor suppressor in many tumor types; induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. One of the activated genes is an inhibitor of cyclin-dependent kinases. Apoptosis induction seems to be mediated either by stimulation of BAX and FAS antigen expression, or by repression of Bcl-2 expression. Its pro-apoptotic activity is activated via its intera [...] (381 aa)
CITED2Cbp/p300 interacting transactivator with Glu/Asp rich carboxy-terminal domain 2. (294 aa)
AK1Endoglin. (848 aa)
ZFPM1Zinc finger protein, FOG family member 1. (986 aa)
PARVAParvin alpha. (459 aa)
NSD2Nuclear receptor binding SET domain protein 2. (1412 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
FZD2Frizzled class receptor 2; Belongs to the G-protein coupled receptor Fz/Smo family. (565 aa)
TBX5T-box transcription factor 5. (518 aa)
PROX1Prospero homeobox 1. (737 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
DHRS3Dehydrogenase/reductase 3. (381 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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