STRINGSTRING
CSMD2 CSMD2 PML PML EPHA2 EPHA2 MED1 MED1 TGFB1 TGFB1 SRC SRC VDR VDR PHB2 PHB2 CSF1 CSF1 AREG AREG ESR1 ESR1 CSMD1 CSMD1 DDR1 DDR1 BTRC BTRC KDM5B KDM5B LRP5 LRP5 ENSECAP00000039988 ENSECAP00000039988 TBX3 TBX3
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
CSMD2CUB and Sushi multiple domains 2. (3633 aa)
PMLPromyelocytic leukemia. (881 aa)
EPHA2EPH receptor A2. (975 aa)
MED1Mediator of RNA polymerase II transcription subunit 1; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. (1581 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
SRCTyrosine-protein kinase. (551 aa)
VDRVitamin D receptor. (427 aa)
PHB2Prohibitin. (299 aa)
CSF1Colony stimulating factor 1. (630 aa)
AREGAmphiregulin. (247 aa)
ESR1Estrogen receptor; Nuclear hormone receptor. The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. Ligand-dependent nuclear transactivation involves either direct homodimer binding to a palindromic estrogen response element (ERE) sequence or association with other DNA-binding transcription factors, such as AP-1/c-Jun, c-Fos, ATF-2, Sp1 and Sp3, to mediate ERE- independent signaling. Ligand binding induces a conformational change allowing subsequent or combinatorial a [...] (608 aa)
CSMD1CUB and Sushi multiple domains 1. (3564 aa)
DDR1Discoidin domain receptor tyrosine kinase 1. (985 aa)
BTRCBeta-transducin repeat containing E3 ubiquitin protein ligase. (605 aa)
KDM5BLysine demethylase 5B. (1536 aa)
LRP5Low-density lipoprotein receptor-related protein; Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes. Belongs to the LDLR family. (1606 aa)
ENSECAP00000039988Prohibitin. (299 aa)
TBX3T-box transcription factor 3. (745 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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