56 items (Equus caballus) - STRING interaction network

Nodes:

Network nodes represent proteins

splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

Node Color

colored nodes:
query proteins and first shell of interactors

white nodes:
second shell of interactors

Node Content

empty nodes:
proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

Edges:

Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

from curated databases

experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

Others

textmining

co-expression

protein homology

Your Input:
	EXOSC7	Exosome component 7. (321 aa)
	CNOT7	CCR4-NOT transcription complex subunit 7. (285 aa)
	PDE12	Phosphodiesterase 12. (609 aa)
	LOC100147364	Ribonuclease UK114-like protein. (137 aa)
	LRRC27	Leucine rich repeat containing 27. (521 aa)
	PABPN1L	Poly(A) binding protein nuclear 1 like, cytoplasmic. (271 aa)
	PNLDC1	PARN like, ribonuclease domain containing 1. (531 aa)
	EXOSC8	Exosome component 8. (276 aa)
	YTHDF3	YTH N6-methyladenosine RNA binding protein 3. (588 aa)
	UPF1	UPF1 RNA helicase and ATPase. (1127 aa)
	CNOT1	CCR4-NOT transcription complex subunit 1. (2376 aa)
	LSM1	U6 snRNA-associated Sm-like protein LSm1; Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. (133 aa)
	MEX3D	Mex-3 RNA binding family member D. (917 aa)
	CNOT6L	CCR4-NOT transcription complex subunit 6 like. (562 aa)
	RIDA	Reactive intermediate imine deaminase A homolog. (137 aa)
	PARN	Poly(A)-specific ribonuclease. (646 aa)
	DCP2	Decapping mRNA 2. (422 aa)
	DIS3L2	DIS3-like exonuclease 2; 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase, such as ZCCHC11/TUT4. Mediates degradation of cytoplasmic mRNAs that have been deadenylated and subsequently uridylated at their 3'. Mediates degradation of uridylated pre-let-7 miRNAs, contributing to the maintenance of embryonic stem (ES) cells. Essential for correct mi [...] (905 aa)
	SAMD4A	Sterile alpha motif domain containing 4A. (758 aa)
	RC3H2	Ring finger and CCCH-type domains 2. (1121 aa)
	CPEB3	Cytoplasmic polyadenylation element binding protein 3. (731 aa)
	NOCT	Nocturnin. (431 aa)
	EXOSC2	Exosome component 2. (342 aa)
	SAMD4B	Sterile alpha motif domain containing 4B. (786 aa)
	RC3H1	Ring finger and CCCH-type domains 1. (1131 aa)
	PATL1	PAT1 homolog 1, processing body mRNA decay factor. (874 aa)
	ENSECAP00000045503	Endo/exonuclease/phosphatase domain-containing protein. (538 aa)
	ZFP36	Uncharacterized protein. (662 aa)
	CNOT3	CCR4-NOT transcription complex subunit 3. (779 aa)
	YTHDF1	YTH N6-methyladenosine RNA binding protein 1. (624 aa)
	DCP1B	Decapping mRNA 1B. (620 aa)
	EXOSC3	Exosome component 3. (275 aa)
	PAN3	PAN2-PAN3 deadenylation complex subunit PAN3; Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA deca [...] (921 aa)
	CNOT2	CCR4-NOT transcription complex subunit 2. (844 aa)
	DHX36	DEAH-box helicase 36. (1029 aa)
	EXOSC9	Exosome component 9. (440 aa)
	DCP1A	Decapping mRNA 1A. (580 aa)
	GIGYF2	GRB10 interacting GYF protein 2. (1284 aa)
	EXOSC5	Exosome component 5. (235 aa)
	YTHDF2	YTH N6-methyladenosine RNA binding protein 2. (580 aa)
	PATL2	PAT1 homolog 2. (542 aa)
	CNOT8	CCR4-NOT transcription complex subunit 8. (292 aa)
	DCPS	Decapping enzyme, scavenger. (337 aa)
	PLEKHN1	Pleckstrin homology domain containing N1. (612 aa)
	ROCK1	Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
	METTL14	Methyltransferase like 14; Belongs to the MT-A70-like family. (456 aa)
	PUM1	Pumilio RNA binding family member 1. (1223 aa)
	TRIM71	Tripartite motif containing 71. (868 aa)
	PNPT1	Polyribonucleotide nucleotidyltransferase 1. (801 aa)
	PAN2	PAN2-PAN3 deadenylation complex catalytic subunit PAN2; Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent [...] (1202 aa)
	CNOT6	CCR4-NOT transcription complex subunit 6. (557 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (510 aa)
	ZC3H12A	Zinc finger CCCH-type containing 12A. (615 aa)
	TARDBP	TAR DNA-binding protein 43-like protein. (414 aa)
	AGO2	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...] (860 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

Send network to Cytoscape

Export your current network:

... as a bitmap image:

download

file format is 'PNG': portable network graphic

... as a high-resolution bitmap:

download

same PNG format, but at higher resolution

... as a vector graphic:

download

SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc

... as short tabular text output:

download

TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)

... as tabular text output:

download

TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)

... as an XML summary:

download

structured XML interaction data, according to the 'PSI-MI' data standard

... protein node degrees:

download

node degree of proteins in your network (given the current score cut-off)

... network coordinates:

download

a flat-file format describing the coordinates and colors of nodes in the network

... protein sequences:

download

MFA: multi-fasta format - containing the aminoacid sequences in the network

... protein annotations:

download

a tab-delimited file describing the names, domains and descriptions of proteins in your network

... functional annotations:

download

a tab-delimited file containing all known functional terms of protiens in your network

Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
AGO2	CNOT1	ENSECAP00000005648	ENSECAP00000008876	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 1.	0.631
AGO2	CNOT2	ENSECAP00000005648	ENSECAP00000024397	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 2.	0.512
AGO2	CNOT7	ENSECAP00000005648	ENSECAP00000004072	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	CCR4-NOT transcription complex subunit 7.	0.505
AGO2	DCP1A	ENSECAP00000005648	ENSECAP00000022294	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Decapping mRNA 1A.	0.680
AGO2	DCP2	ENSECAP00000005648	ENSECAP00000038639	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Decapping mRNA 2.	0.794
AGO2	PATL1	ENSECAP00000005648	ENSECAP00000046182	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	PAT1 homolog 1, processing body mRNA decay factor.	0.702
AGO2	PUM1	ENSECAP00000005648	ENSECAP00000018948	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Pumilio RNA binding family member 1.	0.490
AGO2	RC3H2	ENSECAP00000005648	ENSECAP00000036958	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Ring finger and CCCH-type domains 2.	0.598
AGO2	TRIM71	ENSECAP00000005648	ENSECAP00000018262	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	Tripartite motif containing 71.	0.479
AGO2	UPF1	ENSECAP00000005648	ENSECAP00000008885	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	UPF1 RNA helicase and ATPase.	0.627
CNOT1	AGO2	ENSECAP00000008876	ENSECAP00000005648	CCR4-NOT transcription complex subunit 1.	Protein argonaute-2; Required for RNA-mediated gene silencing (RNAi) by the RNA- induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the [...]	0.631
CNOT1	CNOT2	ENSECAP00000008876	ENSECAP00000024397	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 2.	0.999
CNOT1	CNOT3	ENSECAP00000008876	ENSECAP00000044850	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 3.	0.999
CNOT1	CNOT6	ENSECAP00000008876	ENSECAP00000017032	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6.	0.947
CNOT1	CNOT6L	ENSECAP00000008876	ENSECAP00000041472	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 6 like.	0.990
CNOT1	CNOT7	ENSECAP00000008876	ENSECAP00000004072	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 7.	0.998
CNOT1	CNOT8	ENSECAP00000008876	ENSECAP00000011166	CCR4-NOT transcription complex subunit 1.	CCR4-NOT transcription complex subunit 8.	0.989
CNOT1	DCP1A	ENSECAP00000008876	ENSECAP00000022294	CCR4-NOT transcription complex subunit 1.	Decapping mRNA 1A.	0.518
CNOT1	DCP2	ENSECAP00000008876	ENSECAP00000038639	CCR4-NOT transcription complex subunit 1.	Decapping mRNA 2.	0.505
CNOT1	ENSECAP00000045503	ENSECAP00000008876	ENSECAP00000045503	CCR4-NOT transcription complex subunit 1.	Endo/exonuclease/phosphatase domain-containing protein.	0.947