STRINGSTRING
KCNJ5 KCNJ5 SCN1B SCN1B KCNA5 KCNA5 SCN5A SCN5A KCNE3 KCNE3 NUP155 NUP155 KCNJ2 KCNJ2 RYR2 RYR2 VIL1 VIL1 PIK3CA PIK3CA KCNJ8 KCNJ8 CACNA1D CACNA1D MYL6B MYL6B EPDR1 EPDR1 SCN4B SCN4B ROCK1 ROCK1 CACNA1C CACNA1C SCN3B SCN3B KCNQ1 KCNQ1 PKP2 PKP2 MYH2 MYH2 GSN GSN CCDC88C CCDC88C VILL VILL KCNH2 KCNH2 LOC111772219 LOC111772219 MYL6 MYL6 PARVA PARVA SGCD SGCD PDPN PDPN CACNA2D1 CACNA2D1 EMP2 EMP2 ABCC9-2 ABCC9-2 ENSECAP00000045901 ENSECAP00000045901 LOC111772371 LOC111772371 ENSECAP00000048584 ENSECAP00000048584 MYH6 MYH6 KCNE2 KCNE2 SCN2B SCN2B KCNE1 KCNE1 CACNB2 CACNB2
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
KCNJ5Potassium voltage-gated channel subfamily J member 5. (419 aa)
SCN1BSodium voltage-gated channel beta subunit 1. (218 aa)
KCNA5Potassium voltage-gated channel subfamily A member 5; Belongs to the potassium channel family. (604 aa)
SCN5ASodium channel protein; Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient. (2020 aa)
KCNE3Potassium voltage-gated channel subfamily E regulatory subunit 3. (99 aa)
NUP155Nucleoporin 155. (1391 aa)
KCNJ2Potassium voltage-gated channel subfamily J member 2. (427 aa)
RYR2Ryanodine receptor 2. (4967 aa)
VIL1Villin 1. (827 aa)
PIK3CAPhosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit. (1068 aa)
KCNJ8Potassium voltage-gated channel subfamily J member 8. (424 aa)
CACNA1DVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2209 aa)
MYL6BMyosin light chain 6B. (208 aa)
EPDR1Ependymin related 1. (231 aa)
SCN4BSodium voltage-gated channel beta subunit 4. (228 aa)
ROCK1Rho-associated protein kinase; Protein kinase which is a key regulator of actin cytoskeleton and cell polarity. (1354 aa)
CACNA1CVoltage-dependent L-type calcium channel subunit alpha; Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death; Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family. (2184 aa)
SCN3BSodium voltage-gated channel beta subunit 3. (219 aa)
KCNQ1Potassium voltage-gated channel subfamily Q member 1; Belongs to the potassium channel family. (778 aa)
PKP2Plakophilin 2. (836 aa)
MYH2Myosin-2; Muscle contraction. Required for cytoskeleton organization (By similarity). (1939 aa)
GSNGelsolin; Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis (By similarity). (871 aa)
CCDC88CCoiled-coil domain containing 88C. (2102 aa)
VILLVillin like. (857 aa)
KCNH2Potassium voltage-gated channel subfamily H member 2. (1193 aa)
LOC111772219ATP-sensitive inward rectifier potassium channel 8. (424 aa)
MYL6Myosin light chain 6. (152 aa)
PARVAParvin alpha. (459 aa)
SGCDSarcoglycan delta. (361 aa)
PDPNUncharacterized protein. (152 aa)
CACNA2D1Calcium voltage-gated channel auxiliary subunit alpha2delta 1. (1106 aa)
EMP2Epithelial membrane protein 2; Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion; Belongs to the PMP-22/EMP/MP20 family. (205 aa)
ABCC9-2Uncharacterized protein. (1549 aa)
ENSECAP00000045901annotation not available (424 aa)
LOC111772371Uncharacterized protein. (959 aa)
ENSECAP00000048584Uncharacterized protein. (150 aa)
MYH6Myosin-7; Myosins are actin-based motor molecules with ATPase activity essential for muscle contraction. Forms regular bipolar thick filaments that, together with actin thin filaments, constitute the fundamental contractile unit of skeletal and cardiac muscle. Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. (2081 aa)
KCNE2Potassium voltage-gated channel subfamily E regulatory subunit 2. (123 aa)
SCN2BSodium voltage-gated channel beta subunit 2. (252 aa)
KCNE1Uncharacterized protein. (165 aa)
CACNB2Calcium voltage-gated channel auxiliary subunit beta 2. (660 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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