STRINGSTRING
PRKCZ PRKCZ KDR KDR WNK2 WNK2 FERMT2 FERMT2 DUPD1 DUPD1 FGF1 FGF1 FGF23 FGF23 AGER AGER BMP2 BMP2 APP APP CCL26 CCL26 FBXW7 FBXW7 ERBB4 ERBB4 NOTCH1 NOTCH1 PKHD1 PKHD1 GPR183 GPR183 NDRG2 NDRG2 ROS1 ROS1 CCL8 CCL8 CCL2 CCL2 JUN JUN ITGB1BP1 ITGB1BP1 PTPN22 PTPN22 DNAJC27 DNAJC27 PTPN11 PTPN11 PRKD2 PRKD2 LOC100630171 LOC100630171 PDGFRB PDGFRB F6PYR5_HORSE F6PYR5_HORSE CCL14 CCL14 CCL5 CCL5 CCN1 CCN1 EMILIN1 EMILIN1 FLT4 FLT4 PTK2B PTK2B PTPN1 PTPN1 ADCYAP1 ADCYAP1 FGF19 FGF19 PDGFB PDGFB APELA APELA ENSECAP00000024608 ENSECAP00000024608 DAB2IP DAB2IP SMAD4 SMAD4 FBLN1 FBLN1 LOC111773841 LOC111773841 RRAS RRAS FLCN FLCN YWHAZ YWHAZ PDGFD PDGFD LIF LIF CRKL CRKL FGF18 FGF18 ERBB2 ERBB2 NLRP6 NLRP6 CCL24 CCL24 ENSECAP00000028450 ENSECAP00000028450 ALKAL1 ALKAL1 PHB PHB BRAF BRAF ABL1 ABL1 CD44 CD44 ALKAL2 ALKAL2 HTR2A HTR2A RIPK2 RIPK2 IGF1 IGF1 CCL17 CCL17 CCL13 CCL13 CCL1 CCL1 STYX STYX EGFR EGFR PRKCA PRKCA DLG1 DLG1 CXCL17 CXCL17 CCL25 CCL25 SYK SYK P2RY6 P2RY6 IL26 IL26 CX3CL1 CX3CL1 SPRED1 SPRED1 FRS2 FRS2 PTPRC PTPRC CD74 CD74 FGF4 FGF4 CHI3L1 CHI3L1 ENSECAP00000039988 ENSECAP00000039988 DUSP9 DUSP9 PTPRR PTPRR PDGFA PDGFA LYN LYN RAMP3 RAMP3 GAREM1 GAREM1 NOD1 NOD1 CCL22 CCL22 TRPV4 TRPV4 PDGFRA PDGFRA SEMA6A SEMA6A MFHAS1 MFHAS1 HADHB HADHB RAPGEF1 RAPGEF1 NOTCH2 NOTCH2 RAPGEF2 RAPGEF2 XCL1 XCL1 CCL4 CCL4 NEK10 NEK10 CCL3 CCL3 DENND2B DENND2B CCL11 CCL11 DLG2 DLG2 OPRM1 OPRM1 EPHB2 EPHB2 APIP APIP TNFRSF11A TNFRSF11A SERPINF2 SERPINF2 PTPN6 PTPN6 FGFR4 FGFR4 FBXW9 FBXW9 FGFR3 FGFR3 VRK3 VRK3 CCL16 CCL16 GAS6 GAS6 PRXL2C PRXL2C SEMA7A SEMA7A CXCL17-2 CXCL17-2 CAVIN3 CAVIN3 ACKR3 ACKR3 PTPN2 PTPN2 GPER1 GPER1 SPRY2 SPRY2 NDRG4 NDRG4 F2RL1 F2RL1 ADIPOQ ADIPOQ CSF1R CSF1R F2R F2R RANBP9 RANBP9 SPRY4 SPRY4 DUSP4 DUSP4 C1QL4 C1QL4 SHC1 SHC1 PSCA PSCA THPO THPO C5AR1 C5AR1 LOC100049912 LOC100049912 C5AR2 C5AR2 GPR55 GPR55 PIN1 PIN1 CCL20 CCL20 ZDHHC17 ZDHHC17 FN1 FN1 PLA2G5 PLA2G5 DSTYK DSTYK BMPER BMPER HMGB1 HMGB1 EPHA2 EPHA2 HCRTR1 HCRTR1 CD4 CD4 HAND2 HAND2 PYCARD PYCARD DUSP10 DUSP10 NOX4 NOX4 FGB FGB RASGRP1 RASGRP1 FGF21 FGF21 MAP3K12 MAP3K12 TNIP1 TNIP1 ATF3 ATF3 TGFB1 TGFB1 DUSP3 DUSP3 TBC1D10C TBC1D10C SRC SRC SLC30A10 SLC30A10 GLIPR2 GLIPR2 FSHR FSHR SYNJ2BP SYNJ2BP FAM83D FAM83D LOC111770212 LOC111770212 SPRY1 SPRY1 SAA1 SAA1 EPHB1 EPHB1 EPHA4 EPHA4 LOC100063059 LOC100063059 TLR9 TLR9 FGF10 FGF10 SLAMF1 SLAMF1 SLC9A3R1 SLC9A3R1 FGF2 FGF2 MAPK3 MAPK3 MT3 MT3 DUSP26 DUSP26 TREM2 TREM2 HAVCR2 HAVCR2 RAP1A RAP1A TNFSF11 TNFSF11 CCN2 CCN2 SCIMP SCIMP NODAL NODAL PHB2 PHB2 TEK TEK NOD2 NOD2 BMP4 BMP4 ARHGAP8 ARHGAP8 TRAF7 TRAF7 TIMP3 TIMP3 CIB1 CIB1 LOC100060619 LOC100060619 FFAR4 FFAR4 EZR EZR HTR2B HTR2B CARD9 CARD9 PDGFC PDGFC
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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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query proteins and first shell of interactors
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second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
PRKCZProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (591 aa)
KDRKinase insert domain receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1358 aa)
WNK2WNK lysine deficient protein kinase 2. (2155 aa)
FERMT2Fermitin family member 2. (707 aa)
DUPD1Dual specificity phosphatase DUPD1; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (404 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
FGF23Fibroblast growth factor 23; Belongs to the heparin-binding growth factors family. (244 aa)
AGERAdvanced glycosylation end-product specific receptor. (403 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
APPAmyloid beta precursor protein. (811 aa)
CCL26C-C motif chemokine. (94 aa)
FBXW7F-box and WD repeat domain containing 7. (754 aa)
ERBB4Receptor protein-tyrosine kinase. (1308 aa)
NOTCH1Notch receptor 1. (2581 aa)
PKHD1PKHD1 ciliary IPT domain containing fibrocystin/polyductin. (4077 aa)
GPR183G-protein coupled receptor 183-like protein; Belongs to the G-protein coupled receptor 1 family. (357 aa)
NDRG2NDRG family member 2. (371 aa)
ROS1Tyrosine-protein kinase receptor. (2342 aa)
CCL8SCY domain-containing protein. (99 aa)
CCL2C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa)
JUNJun proto-oncogene, AP-1 transcription factor subunit; Belongs to the bZIP family. (340 aa)
ITGB1BP1Integrin subunit beta 1 binding protein 1. (200 aa)
PTPN22Protein tyrosine phosphatase non-receptor type 22. (830 aa)
DNAJC27DnaJ heat shock protein family (Hsp40) member C27. (273 aa)
PTPN11Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (606 aa)
PRKD2Serine/threonine-protein kinase; Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. (878 aa)
LOC100630171C-C motif chemokine. (140 aa)
PDGFRBPlatelet-derived growth factor receptor beta; Tyrosine-protein kinase that acts as cell-surface receptor for homodimeric PDGFB and PDGFD and for heterodimers formed by PDGFA and PDGFB, and plays an essential role in the regulation of embryonic development, cell proliferation, survival, differentiation, chemotaxis and migration. Plays an essential role in blood vessel development by promoting proliferation, migration and recruitment of pericytes and smooth muscle cells to endothelial cells. (1106 aa)
F6PYR5_HORSEC-C motif chemokine. (121 aa)
CCL14C-C motif chemokine. (95 aa)
CCL5C-C motif chemokine 5; Chemoattractant for blood monocytes, memory T-helper cells and eosinophils. Causes the release of histamine from basophils and activates eosinophils. May activate several chemokine receptors including CCR1, CCR3, CCR4 and CCR5. May also be an agonist of the G protein-coupled receptor GPR75. Together with GPR75, may play a role in neuron survival through activation of a downstream signaling pathway involving the PI3, Akt and MAP kinases. By activating GPR75 may also play a role in insulin secretion by islet cells. Belongs to the intercrine beta (chemokine CC) family. (91 aa)
CCN1Cellular communication network factor 1. (382 aa)
EMILIN1Elastin microfibril interfacer 1. (1016 aa)
FLT4Fms related tyrosine kinase 4; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (1366 aa)
PTK2BProtein tyrosine kinase 2 beta; Belongs to the protein kinase superfamily. Tyr protein kinase family. (1081 aa)
PTPN1Protein tyrosine phosphatase non-receptor type 1. (493 aa)
ADCYAP1Adenylate cyclase activating polypeptide 1. (170 aa)
FGF19Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (219 aa)
PDGFBPlatelet derived growth factor subunit B; Belongs to the PDGF/VEGF growth factor family. (249 aa)
APELAUncharacterized protein. (53 aa)
ENSECAP00000024608Uncharacterized protein. (127 aa)
DAB2IPDAB2 interacting protein. (1166 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
FBLN1Fibulin-1; Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes. (753 aa)
LOC111773841G_PROTEIN_RECEP_F1_2 domain-containing protein. (358 aa)
RRASRAS related. (220 aa)
FLCNUDENN FLCN/SMCR8-type domain-containing protein. (829 aa)
YWHAZTyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein zeta; Belongs to the 14-3-3 family. (247 aa)
PDGFDPlatelet derived growth factor D. (566 aa)
LIFLIF interleukin 6 family cytokine. (203 aa)
CRKLCRK like proto-oncogene, adaptor protein. (303 aa)
FGF18Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (207 aa)
ERBB2Receptor protein-tyrosine kinase. (1255 aa)
NLRP6NLR family pyrin domain containing 6. (892 aa)
CCL24C-C motif chemokine ligand 24. (109 aa)
ENSECAP00000028450SCY domain-containing protein. (96 aa)
ALKAL1ALK and LTK ligand 1. (129 aa)
PHBProhibitin. (297 aa)
BRAFB-Raf proto-oncogene, serine/threonine kinase. (793 aa)
ABL1Tyrosine-protein kinase. (1149 aa)
CD44CD44 antigen. (700 aa)
ALKAL2Uncharacterized protein. (576 aa)
HTR2A5-hydroxytryptamine receptor 2A. (470 aa)
RIPK2Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa)
IGF1Insulin-like growth factor I; The insulin-like growth factors, isolated from plasma, are structurally and functionally related to insulin but have a much higher growth-promoting activity. May be a physiological regulator of [1-14C]- 2-deoxy-D-glucose (2DG) transport and glycogen synthesis in osteoblasts. Stimulates glucose transport in bone-derived osteoblastic (PyMS) cells and is effective at much lower concentrations than insulin, not only regarding glycogen and DNA synthesis but also with regard to enhancing glucose uptake. May play a role in synapse maturation. Ca(2+)-dependent exo [...] (195 aa)
CCL17C-C motif chemokine. (198 aa)
CCL13SCY domain-containing protein. (264 aa)
CCL1SCY domain-containing protein. (94 aa)
STYXSerine/threonine/tyrosine interacting protein. (223 aa)
EGFRReceptor protein-tyrosine kinase. (1195 aa)
PRKCAProtein kinase C; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. (690 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
CXCL17Uncharacterized protein. (119 aa)
CCL25C-C motif chemokine ligand 25. (151 aa)
SYKTyrosine-protein kinase. (716 aa)
P2RY6Pyrimidinergic receptor P2Y6. (428 aa)
IL26Interleukin 26. (180 aa)
CX3CL1SCY domain-containing protein. (561 aa)
SPRED1Sprouty related EVH1 domain containing 1. (442 aa)
FRS2Fibroblast growth factor receptor substrate 2. (515 aa)
PTPRCProtein tyrosine phosphatase receptor type C. (1399 aa)
CD74CD74 molecule. (272 aa)
FGF4Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (206 aa)
CHI3L1Chitinase 3 like 1; Belongs to the glycosyl hydrolase 18 family. (427 aa)
ENSECAP00000039988Prohibitin. (299 aa)
DUSP9Dual specificity phosphatase 9. (557 aa)
PTPRRProtein tyrosine phosphatase receptor type R. (654 aa)
PDGFAPDGF_2 domain-containing protein; Belongs to the PDGF/VEGF growth factor family. (569 aa)
LYNTyrosine-protein kinase. (533 aa)
RAMP3Uncharacterized protein. (224 aa)
GAREM1GRB2 associated regulator of MAPK1 subtype 1. (880 aa)
NOD1Nucleotide binding oligomerization domain containing 1. (993 aa)
CCL22C-C motif chemokine ligand 22. (98 aa)
TRPV4Transient receptor potential cation channel subfamily V member 4; Belongs to the transient receptor (TC 1.A.4) family. (857 aa)
PDGFRAPlatelet-derived growth factor receptor alpha; Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. (1089 aa)
SEMA6ASemaphorin 6A; Belongs to the semaphorin family. (1047 aa)
MFHAS1Malignant fibrous histiocytoma amplified sequence 1. (1046 aa)
HADHBGRB2 associated regulator of MAPK1 subtype 2. (873 aa)
RAPGEF1Rap guanine nucleotide exchange factor 1. (1465 aa)
NOTCH2Notch receptor 2. (2471 aa)
RAPGEF2Rap guanine nucleotide exchange factor 2. (1722 aa)
XCL1SCY domain-containing protein. (206 aa)
CCL4SCY domain-containing protein. (97 aa)
NEK10NIMA related kinase 10. (1188 aa)
CCL3SCY domain-containing protein. (226 aa)
DENND2BSuppression of tumorigenicity 5. (1192 aa)
CCL11Eotaxin; In response to the presence of allergens, this protein directly promotes the accumulation of eosinophils, a prominent feature of allergic inflammatory reactions. Binds to CCR3 (By similarity). Belongs to the intercrine beta (chemokine CC) family. (102 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
OPRM1Opioid receptor mu 1; Belongs to the G-protein coupled receptor 1 family. (447 aa)
EPHB2EPH receptor B2. (1018 aa)
APIPMethylthioribulose-1-phosphate dehydratase; Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death; Belongs to the aldolase class II family. MtnB subfamily. (422 aa)
TNFRSF11ATNF receptor superfamily member 11a. (647 aa)
SERPINF2Serpin family F member 2; Belongs to the serpin family. (491 aa)
PTPN6Tyrosine-protein phosphatase non-receptor type; Belongs to the protein-tyrosine phosphatase family. Non- receptor class 2 subfamily. (597 aa)
FGFR4Fibroblast growth factor receptor. (855 aa)
FBXW9F-box and WD repeat domain containing 9. (477 aa)
FGFR3Fibroblast growth factor receptor. (804 aa)
VRK3VRK serine/threonine kinase 3. (403 aa)
CCL16C-C motif chemokine. (164 aa)
GAS6Growth arrest specific 6. (646 aa)
PRXL2CPeroxiredoxin like 2C. (226 aa)
SEMA7ASemaphorin 7A; Belongs to the semaphorin family. (664 aa)
CXCL17-2C-X-C motif chemokine ligand 17. (133 aa)
CAVIN3Caveolae associated protein 3. (261 aa)
ACKR3Atypical chemokine receptor 3; Belongs to the G-protein coupled receptor 1 family. (362 aa)
PTPN2Tyrosine-protein phosphatase non-receptor type. (388 aa)
GPER1G protein-coupled estrogen receptor 1; Belongs to the G-protein coupled receptor 1 family. (370 aa)
SPRY2Sprouty RTK signaling antagonist 2. (315 aa)
NDRG4NDRG family member 4. (504 aa)
F2RL1F2R like trypsin receptor 1. (397 aa)
ADIPOQAdiponectin, C1Q and collagen domain containing. (301 aa)
CSF1RColony stimulating factor 1 receptor; Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily. (968 aa)
F2RCoagulation factor II thrombin receptor; Belongs to the G-protein coupled receptor 1 family. (428 aa)
RANBP9RAN binding protein 9. (728 aa)
SPRY4Sprouty RTK signaling antagonist 4. (321 aa)
DUSP4Dual specificity protein phosphatase; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (411 aa)
C1QL4Complement C1q like 4. (238 aa)
SHC1SHC adaptor protein 1. (584 aa)
PSCAProstate stem cell antigen. (115 aa)
THPOThrombopoietin. (350 aa)
C5AR1Complement C5a receptor 1; Belongs to the G-protein coupled receptor 1 family. (374 aa)
LOC100049912Uncharacterized protein. (184 aa)
C5AR2Complement component 5a receptor 2. (337 aa)
GPR55G protein-coupled receptor 55; Belongs to the G-protein coupled receptor 1 family. (371 aa)
PIN1Peptidyl-prolyl cis-trans isomerase. (164 aa)
CCL20C-C motif chemokine. (96 aa)
ZDHHC17Palmitoyltransferase; Belongs to the DHHC palmitoyltransferase family. (648 aa)
FN1Fibronectin; Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape. Involved in osteoblast compaction through the fibronectin fibrillogenesis cell-mediated matrix assembly process, essential for osteoblast mineralization. Participates in the regulation of type I collagen deposition by osteoblasts (By similarity). (2477 aa)
PLA2G5Phospholipase A(2). (158 aa)
DSTYKDual serine/threonine and tyrosine protein kinase. (928 aa)
BMPERBMP binding endothelial regulator. (685 aa)
HMGB1High mobility group protein B1; Multifunctional redox sensitive protein with various roles in different cellular compartments. In the nucleus is one of the major chromatin-associated non-histone proteins and acts as a DNA chaperone involved in replication, transcription, chromatin remodeling, V(D)J recombination, DNA repair and genome stability. Proposed to be an universal biosensor for nucleic acids. Promotes host inflammatory response to sterile and infectious signals and is involved in the coordination and integration of innate and adaptive immune responses. In the cytoplasm functio [...] (215 aa)
EPHA2EPH receptor A2. (975 aa)
HCRTR1Hypocretin receptor 1; Belongs to the G-protein coupled receptor 1 family. (425 aa)
CD4CD4 molecule. (460 aa)
HAND2Heart and neural crest derivatives expressed 2. (217 aa)
PYCARDPYD and CARD domain containing. (195 aa)
DUSP10Dual specificity phosphatase 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (482 aa)
NOX4NADPH oxidase 4. (577 aa)
FGBFibrinogen beta chain; Cleaved by the protease thrombin to yield monomers which, together with fibrinogen alpha (FGA) and fibrinogen gamma (FGG), polymerize to form an insoluble fibrin matrix. Fibrin has a major function in hemostasis as one of the primary components of blood clots. In addition, functions during the early stages of wound repair to stabilize the lesion and guide cell migration during re- epithelialization. Was originally thought to be essential for platelet aggregation, based on in vitro studies using anticoagulated blood. However subsequent studies have shown that it i [...] (495 aa)
RASGRP1RAS guanyl releasing protein 1. (797 aa)
FGF21Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (209 aa)
MAP3K12Mitogen-activated protein kinase kinase kinase 12; May be an activator of the JNK/SAPK pathway. (892 aa)
TNIP1TNFAIP3 interacting protein 1. (723 aa)
ATF3Activating transcription factor 3. (251 aa)
TGFB1Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa)
DUSP3Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (202 aa)
TBC1D10CTBC1 domain family member 10C. (450 aa)
SRCTyrosine-protein kinase. (551 aa)
SLC30A10Solute carrier family 30 member 10. (479 aa)
GLIPR2GLI pathogenesis related 2; Belongs to the CRISP family. (154 aa)
FSHRFollicle-stimulating hormone receptor; G protein-coupled receptor for follitropin, the follicle- stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways. (694 aa)
SYNJ2BPPDZ domain-containing protein. (145 aa)
FAM83DFamily with sequence similarity 83 member D. (615 aa)
LOC111770212C-C motif chemokine. (100 aa)
SPRY1Sprouty RTK signaling antagonist 1. (366 aa)
SAA1Serum amyloid A protein; Major acute phase reactant. Apolipoprotein of the HDL complex. (162 aa)
EPHB1EPH receptor B1. (984 aa)
EPHA4EPH receptor A4. (949 aa)
LOC100063059SCY domain-containing protein. (131 aa)
TLR9Toll-like receptor 9; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. TLR9 is a nucleotide-sensing TLR which is activated by unmethylated cytidine- phosphate-guanosine (CpG) dinucleotides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Upon CpG stimulation, induces B-cell proliferation, activation, survival and antibody production (By similarity). (1031 aa)
FGF10Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (216 aa)
SLAMF1Signaling lymphocytic activation molecule family member 1. (338 aa)
SLC9A3R1Na(+)/H(+) exchange regulatory cofactor NHE-RF; Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. (365 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
MAPK3Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa)
MT3Metallothionein-3; Binds heavy metals. Contains three zinc and three copper atoms per polypeptide chain and only a negligible amount of cadmium; Belongs to the metallothionein superfamily. Type 1 family. (68 aa)
DUSP26Dual specificity protein phosphatase; Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. Belongs to the protein-tyrosine phosphatase family. Non- receptor class dual specificity subfamily. (211 aa)
TREM2Triggering receptor expressed on myeloid cells 2. (298 aa)
HAVCR2Hepatitis A virus cellular receptor 2. (280 aa)
RAP1ARAP1A, member of RAS oncogene family. (184 aa)
TNFSF11Tumor necrosis factor ligand superfamily member. (318 aa)
CCN2Cellular communication network factor 2. (475 aa)
SCIMPSLP adaptor and CSK interacting membrane protein. (142 aa)
NODALNodal growth differentiation factor. (348 aa)
PHB2Prohibitin. (299 aa)
TEKTEK receptor tyrosine kinase. (1153 aa)
NOD2Nucleotide binding oligomerization domain containing 2. (1013 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
ARHGAP8Uncharacterized protein. (468 aa)
TRAF7TNF receptor associated factor 7. (684 aa)
TIMP3Metalloproteinase inhibitor 3; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor. May form part of a tissue-specific acute response to remodeling stimuli. (211 aa)
CIB1Calcium and integrin binding 1. (191 aa)
LOC100060619SCY domain-containing protein. (124 aa)
FFAR4Free fatty acid receptor 4. (361 aa)
EZREzrin. (830 aa)
HTR2B5-hydroxytryptamine receptor 2B. (503 aa)
CARD9Caspase recruitment domain family member 9. (537 aa)
PDGFCPlatelet derived growth factor C; Belongs to the PDGF/VEGF growth factor family. (368 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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