STRINGSTRING
TGFBR1 TGFBR1 INTS8 INTS8 SMAD3 SMAD3 SMAD2 SMAD2 SMAD4 SMAD4 AXIN1 AXIN1 SMAD1 SMAD1 SMAD7 SMAD7 SMAD5 SMAD5 AXIN2 AXIN2 SMURF1 SMURF1 SMAD6 SMAD6 SMAD9 SMAD9 TGFB1I1 TGFB1I1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
TGFBR1Receptor protein serine/threonine kinase; Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. (503 aa)
INTS8Integrator complex subunit 8. (1081 aa)
SMAD3Mothers against decapentaplegic homolog. (425 aa)
SMAD2Mothers against decapentaplegic homolog. (610 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
AXIN1Axin 1. (939 aa)
SMAD1Mothers against decapentaplegic homolog. (465 aa)
SMAD7Mothers against decapentaplegic homolog. (426 aa)
SMAD5Mothers against decapentaplegic homolog. (465 aa)
AXIN2Axin 2. (843 aa)
SMURF1E3 ubiquitin-protein ligase. (757 aa)
SMAD6Mothers against decapentaplegic homolog. (498 aa)
SMAD9Mothers against decapentaplegic homolog. (430 aa)
TGFB1I1Transforming growth factor beta-1-induced transcript 1 protein; Functions as a molecular adapter coordinating multiple protein-protein interactions at the focal adhesion complex and in the nucleus. Links various intracellular signaling modules to plasma membrane receptors and regulates the Wnt and TGFB signaling pathways. (461 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
Server load: medium (44%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.