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| | LOC111767791 | CD14 molecule. (376 aa) |
| | TLR6 | Toll-like receptor. (859 aa) |
| | TNF | Tumor necrosis factor, membrane form; Cytokine that binds to TNFRSF1A/TNFR1 and TNFRSF1B/TNFBR. It is mainly secreted by macrophages and can induce cell death of certain tumor cell lines. It is potent pyrogen causing fever by direct action or by stimulation of interleukin-1 secretion and is implicated in the induction of cachexia, Under certain conditions it can stimulate cell proliferation and induce cell differentiation (By similarity). Induces insulin resistance in adipocytes via inhibition of insulin-induced IRS1 tyrosine phosphorylation and insulin-induced glucose uptake. Induces [...] (253 aa) |
| | MYD88 | Myeloid differentiation primary response protein MyD88; Adapter protein involved in the Toll-like receptor and IL-1 receptor signaling pathway in the innate immune response. (309 aa) |
| | PRKCE | Protein kinase C epsilon type; Calcium-independent, phospholipid- and diacylglycerol (DAG)- dependent serine/threonine-protein kinase that plays essential roles in the regulation of multiple cellular processes linked to cytoskeletal proteins, such as cell adhesion, motility, migration and cell cycle, functions in neuron growth and ion channel regulation, and is involved in immune response, cancer cell invasion and regulation of apoptosis. Mediates cell adhesion to the extracellular matrix via integrin- dependent signaling, by mediating angiotensin-2-induced activation of integrin beta- [...] (737 aa) |
| | F7A4E6_HORSE | DUF4939 domain-containing protein. (215 aa) |
| | LDOC1 | LDOC1 regulator of NFKB signaling. (146 aa) |
| | NR1D1 | Nuclear receptor subfamily 1 group D member 1. (605 aa) |
| | ADAM9 | ADAM metallopeptidase domain 9. (819 aa) |
| | IL10 | Interleukin-10; Major immune regulatory cytokine that acts on many cells of the immune system where it has profound anti-inflammatory functions, limiting excessive tissue disruption caused by inflammation. Mechanistically, IL10 binds to its heterotetrameric receptor comprising IL10RA and IL10RB leading to JAK1 and STAT2-mediated phosphorylation of STAT3. In turn, STAT3 translocates to the nucleus where it drives expression of anti-inflammatory mediators. Targets antigen-presenting cells (APCs) such as macrophages and monocytes and inhibits their release of pro-inflammatory cytokines in [...] (249 aa) |
| | ACOD1 | Aconitate decarboxylase 1. (482 aa) |
| | GIT1 | GIT ArfGAP 1. (770 aa) |
| | ZC3H12A | Zinc finger CCCH-type containing 12A. (615 aa) |
| | TNFAIP3 | TNF alpha induced protein 3. (794 aa) |
| | CHMP5 | Charged multivesicular body protein 5. (219 aa) |
| | PYCARD | PYD and CARD domain containing. (195 aa) |
| | TLR4 | Toll-like receptor 4; Cooperates with LY96 and CD14 to mediate the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MYD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Also involved in LPS-independent inflammatory responses triggered by free fatty acids, such as palmitate. In complex with TLR6, promotes sterile inflammation in monocytes/macrophages in response to oxidized low-density lipoprotein (oxLDL) or amyloid-beta 42. In this context, the initial signal is provided by oxLDL- or amyloid-beta 42-binding to [...] (843 aa) |
| | UPF1 | UPF1 RNA helicase and ATPase. (1127 aa) |
| | TNIP1 | TNFAIP3 interacting protein 1. (723 aa) |
| | CD6 | CD6 molecule. (673 aa) |
| | CTR9 | CTR9 homolog, Paf1/RNA polymerase II complex component. (1173 aa) |
| | TGFB1 | Transforming growth factor beta-1 proprotein; Transforming growth factor beta-1 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-1 (TGF-beta-1) chains, which constitute the regulatory and active subunit of TGF-beta-1, respectively. Transforming growth factor beta-1: Multifunctional protein that regulates the growth and differentiation of various cell types and is involved in various processes, such as normal development, immune function, microglia function and responses to neurodegeneration (By similarity). Activation into mature form fo [...] (390 aa) |
| | DEFA1 | Alpha-defensin 1; Has broad-spectrum antimicrobial properties. The antimicrobial activity decreases in the present of salt in vitro. Binds anionic phospholipids, which leads to the aggregation of liposomes in vitro. Membrane permeabilization of the target cells is an essential part of the peptide's mode of antimicrobial activity. No hemolytic activity against sheep or horse erythrocytes. Has antibacterial activity against the bacterial horse pathogens Gram-positive R.equi ATCC 33701 P(-) (minimum bactericidal concentration or MBC=5 ug/ml) and R.equi ATCC 33701 P(+) (MBC=5 ug/ml), which [...] (98 aa) |
| | CXCL13 | C-X-C motif chemokine. (110 aa) |
| | AXL | AXL receptor tyrosine kinase. (887 aa) |
| | CXCL11 | C-X-C motif chemokine. (100 aa) |
| | SELENOS | Selenoprotein S. (188 aa) |
| | LOC100630489 | C-X-C motif chemokine. (110 aa) |
| | PPBP | C-X-C motif chemokine. (146 aa) |
| | CMPK2 | Cytidine/uridine monophosphate kinase 2. (447 aa) |
| | CXCL6 | C-X-C motif chemokine 6; Chemotactic for neutrophil granulocytes. Signals through binding and activation of its receptors (CXCR1 and CXCR2). In addition to its chemotactic and angiogenic properties, it has strong antibacterial activity against Gram-positive and Gram-negative bacteria (90-fold-higher when compared to CXCL5 and CXCL7) (By similarity). Belongs to the intercrine alpha (chemokine CxC) family. (113 aa) |
| | TICAM2 | TIR domain-containing protein. (238 aa) |
| | IL12B | Interleukin-12 subunit beta; Cytokine that can act as a growth factor for activated T and NK cells, enhance the lytic activity of NK/lymphokine-activated killer cells, and stimulate the production of IFN-gamma by resting PBMC. Belongs to the IL-12B family. (329 aa) |
| | IRAK2 | Interleukin 1 receptor associated kinase 2. (621 aa) |
| | CXCL10 | C-X-C motif chemokine. (104 aa) |
| | MALT1 | MALT1 paracaspase. (850 aa) |
| | RELA | RELA proto-oncogene, NF-kB subunit. (551 aa) |
| | MAPK3 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (382 aa) |
| | LBP | Lipopolysaccharide binding protein. (481 aa) |
| | TREM2 | Triggering receptor expressed on myeloid cells 2. (298 aa) |
| | HAVCR2 | Hepatitis A virus cellular receptor 2. (280 aa) |
| | CXCL8 | Interleukin-8; IL-8 is a chemotactic factor that attracts neutrophils, basophils, and T-cells, but not monocytes. It is also involved in neutrophil activation. It is released from several cell types in response to an inflammatory stimulus (By similarity). (101 aa) |
| | NR1H3 | Nuclear receptor subfamily 1 group H member 3. (447 aa) |
| | PLSCR3 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. (295 aa) |
| | IL6 | Interleukin-6; Cytokine with a wide variety of biological functions. It is a potent inducer of the acute phase response. Plays an essential role in the final differentiation of B-cells into Ig-secreting cells Involved in lymphocyte and monocyte differentiation. Acts on B-cells, T-cells, hepatocytes, hematopoietic progenitor cells and cells of the CNS. Required for the generation of T(H)17 cells. Also acts as a myokine. It is discharged into the bloodstream after muscle contraction and acts to increase the breakdown of fats and to improve insulin resistance. It induces myeloma and plasm [...] (231 aa) |
| | DEFB124 | Beta-defensin; Has antibacterial activity; Belongs to the beta-defensin family. (71 aa) |
| | CD180 | CD180 molecule. (661 aa) |
| | KLRK1 | Killer cell lectin like receptor K1. (232 aa) |
| | NOD2 | Nucleotide binding oligomerization domain containing 2. (1013 aa) |
| | LY96 | Lymphocyte antigen 96. (173 aa) |
| | CLEC17A | C-type lectin domain containing 17A. (313 aa) |
| | TLR2 | Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa) |
| | NR1H4 | Nuclear receptor subfamily 1 group H member 4. (486 aa) |
| | IRF3 | Interferon regulatory factor 3. (426 aa) |
| | CCDC142 | Coiled-coil domain containing 142. (763 aa) |
| | IL36B | Interleukin-1. (158 aa) |
| | PLAA | Phospholipase A2 activating protein. (863 aa) |
| | IL36RN | Interleukin-1. (155 aa) |
| | TRAF6 | TNF receptor-associated factor; Belongs to the TNF receptor-associated factor family. (564 aa) |
| | TNFSF4 | Tumor necrosis factor ligand 2B; Belongs to the tumor necrosis factor family. (183 aa) |
| | IL1F10 | Interleukin-1. (152 aa) |
| | NFKBIA | NFKB inhibitor alpha. (543 aa) |
| | ARID5A | AT-rich interaction domain 5A. (601 aa) |
| | IL1A | Interleukin-1 alpha; Produced by activated macrophages, IL-1 stimulates thymocyte proliferation by inducing IL-2 release, B-cell maturation and proliferation, and fibroblast growth factor activity. IL-1 proteins are involved in the inflammatory response, being identified as endogenous pyrogens, and are reported to stimulate the release of prostaglandin and collagenase from synovial cells (By similarity). (270 aa) |
| | CCL2 | C-C motif chemokine 2; Acts as a ligand for C-C chemokine receptor CCR2 (By similarity). Signals through binding and activation of CCR2 and induces a strong chemotactic response and mobilization of intracellular calcium ions (By similarity). Exhibits a chemotactic activity for monocytes and basophils but not neutrophils or eosinophils (By similarity). Plays an important role in mediating peripheral nerve injury-induced neuropathic pain (By similarity). Increases NMDA-mediated synaptic transmission in both dopamine D1 and D2 receptor-containing neurons, which may be caused by MAPK/ERK-d [...] (99 aa) |
| | F6YCD0_HORSE | Uncharacterized protein. (478 aa) |
| | SCARB1 | Scavenger receptor class B member 1; Belongs to the CD36 family. (509 aa) |
| | BPIFC | BPI fold containing family C. (507 aa) |
| | NOS2 | Nitric oxide synthase; Produces nitric oxide (NO). (1247 aa) |
| | BCL10 | BCL10 immune signaling adaptor. (374 aa) |
| | NFKBIL1 | NFKB inhibitor like 1. (380 aa) |
| | MRC1 | Mannose receptor C-type 1. (1514 aa) |
| | PDCD1LG2 | Programmed cell death 1 ligand 2. (291 aa) |
| | NUGGC | Nuclear GTPase, germinal center associated. (815 aa) |
| | DAB2IP | DAB2 interacting protein. (1166 aa) |
| | GFI1 | Growth factor independent 1 transcriptional repressor. (422 aa) |
| | MEF2C | Myocyte enhancer factor 2C. (483 aa) |
| | IL36A | Interleukin-1. (178 aa) |
| | TLR1 | Toll-like receptor. (756 aa) |
| | MTDH | Metadherin. (615 aa) |
| | LOC111768185 | Multifunctional fusion protein; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production; Belongs to the IL-1 family. (266 aa) |
| | LITAF | Lipopolysaccharide induced TNF factor. (184 aa) |
| | BPI | Bactericidal permeability increasing protein. (588 aa) |
| | SIRT2 | Sirtuin 2. (462 aa) |
| | ENSECAP00000030557 | Uncharacterized protein. (146 aa) |
| | ANKRD1 | Ankyrin repeat domain 1. (381 aa) |
| | TNIP3 | TNFAIP3 interacting protein 3. (393 aa) |
| | LOC111772122 | Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa) |
| | ABL1 | Tyrosine-protein kinase. (1149 aa) |
| | PLCG2 | Phosphoinositide phospholipase C. (1331 aa) |
| | CD80 | CD80 molecule. (305 aa) |
| | RIPK2 | Receptor-interacting serine/threonine-protein kinase 2; Serine/threonine/tyrosine kinase that plays an essential role in modulation of innate and adaptive immune responses. Upon stimulation by bacterial peptidoglycans, NOD1 and NOD2 are activated, oligomerize and recruit RIPK2 through CARD-CARD domains. (569 aa) |
| | LOC111771935 | Toll-like receptor 4. (843 aa) |
| | DEFA35L | Defensin_propep domain-containing protein; Belongs to the alpha-defensin family. (75 aa) |
| | DEFA36L | Paneth cell-specific alpha-defensin 36L; Belongs to the alpha-defensin family. (75 aa) |
| | DEFA22 | Defensin_propep domain-containing protein. (100 aa) |
| | ENSECAP00000036381 | TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa) |
| | BCR | BCR activator of RhoGEF and GTPase. (1325 aa) |
| | CACTIN | Cactin, spliceosome C complex subunit. (753 aa) |
| | CD86 | CD86 molecule. (335 aa) |
| | CXCL1 | C-X-C motif chemokine. (113 aa) |
| | IL18 | Interleukin-18; A proinflammatory cytokine primarily involved in polarized T- helper 1 (Th1) cell and natural killer (NK) cell immune responses. Upon binding to IL18R1 and IL18RAP, forms a signaling ternary complex which activates NF-kappa-B, triggering synthesis of inflammatory mediators. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells and natural killer (NK) cells. Belongs to the IL-1 family. (193 aa) |
| | SBNO2 | Strawberry notch homolog 2. (1370 aa) |
| | CD274 | CD274 molecule. (301 aa) |
| | DEFA8 | Paneth cell-specific alpha-defensin 8. (98 aa) |
| | LYN | Tyrosine-protein kinase. (533 aa) |
| | PAF1 | PAF1 homolog, Paf1/RNA polymerase II complex component. (582 aa) |
| | CD14 | CD14 molecule. (369 aa) |
| | DEFA20 | Paneth cell-specific alpha-defensin 23. (100 aa) |
| | IL36G | Interleukin-1. (167 aa) |
| | PDCD4 | Programmed cell death 4. (479 aa) |
| | IRAK1 | Interleukin 1 receptor associated kinase 1. (805 aa) |
| | ENSECAP00000044919 | Defensin_propep domain-containing protein. (94 aa) |
| | ZFP36 | Uncharacterized protein. (662 aa) |
| | FAM49B | Family with sequence similarity 49 member B. (494 aa) |
| | TNIP2 | TNFAIP3 interacting protein 2. (592 aa) |
| | DEFA5 | Uncharacterized protein. (98 aa) |
| | CCL3 | SCY domain-containing protein. (226 aa) |
| | MAPK1 | Mitogen-activated protein kinase; Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. (594 aa) |
| | IL37 | Interleukin-1. (218 aa) |
| | STAP1 | Signal transducing adaptor family member 1. (297 aa) |
| | NFKBIB | NFKB inhibitor beta. (371 aa) |
| | PDE4B | Phosphodiesterase. (736 aa) |
| | XBP1 | BZIP domain-containing protein. (378 aa) |
| | IRF8 | Interferon regulatory factor 8. (492 aa) |
| | TNFRSF1B | TNF receptor superfamily member 1B. (481 aa) |
| | IL1B | Interleukin-1 beta; Potent proinflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B- cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T- helper 1 (Th1) cells. (268 aa) |
