24 items (Equus caballus) - STRING interaction network

Nodes:

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splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.

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query proteins and first shell of interactors

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second shell of interactors

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proteins of unknown 3D structure

filled nodes:
a 3D structure is known or predicted

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Edges represent protein-protein associations

associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.

Known Interactions

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experimentally determined

Predicted Interactions

gene neighborhood

gene fusions

gene co-occurrence

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textmining

co-expression

protein homology

Your Input:
	AQP1	Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
	MYOD1	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation. (319 aa)
	DDIT4	DNA damage inducible transcript 4. (231 aa)
	SSTR5	Somatostatin receptor 5; Belongs to the G-protein coupled receptor 1 family. (365 aa)
	SSTR3	Somatostatin receptor 3; Belongs to the G-protein coupled receptor 1 family. (420 aa)
	HNRNPU	Heterogeneous nuclear ribonucleoprotein U. (825 aa)
	NPAS4	Neuronal PAS domain protein 4. (802 aa)
	PCK1	Phosphoenolpyruvate carboxykinase 1. (622 aa)
	RPS6KB1	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. (525 aa)
	FBXO32	F-box protein 32. (355 aa)
	ANXA1	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...] (346 aa)
	ZFP36L2	ZFP36 ring finger protein like 2. (510 aa)
	ZFP36L1	ZFP36 ring finger protein like 1. (338 aa)
	GSK3A	Protein kinase domain-containing protein; Belongs to the protein kinase superfamily. (483 aa)
	MSTN	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family. (375 aa)
	SMYD3	SET and MYND domain containing 3. (428 aa)
	EIF4E	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family. (236 aa)
	SSTR2	Somatostatin receptor 2; Belongs to the G-protein coupled receptor 1 family. (369 aa)
	TFAP4	Transcription factor AP-4. (338 aa)
	REST	RE1 silencing transcription factor. (1039 aa)
	PCK2	Phosphoenolpyruvate carboxykinase 2, mitochondrial. (646 aa)
	NR3C1	Nuclear receptor subfamily 3 group C member 1. (776 aa)
	CASP9	Caspase 9; Belongs to the peptidase C14A family. (632 aa)
	ZFP36	Uncharacterized protein. (662 aa)

Your Current Organism:

Equus caballus

NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
ANXA1	CASP9	ENSECAP00000013992	ENSECAP00000039254	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	Caspase 9; Belongs to the peptidase C14A family.	0.573
CASP9	ANXA1	ENSECAP00000039254	ENSECAP00000013992	Caspase 9; Belongs to the peptidase C14A family.	Annexin A1; Plays important roles in the innate immune response as effector of glucocorticoid-mediated responses and regulator of the inflammatory process. Has anti-inflammatory activity. Plays a role in glucocorticoid-mediated down-regulation of the early phase of the inflammatory response. Promotes resolution of inflammation and wound healing (By similarity). Functions at least in part by activating the formyl peptide receptors and downstream signaling cascades. Promotes chemotaxis of granulocytes and monocytes via activation of the formyl peptide receptors (By similarity). Contribut [...]	0.573
EIF4E	RPS6KB1	ENSECAP00000052494	ENSECAP00000012006	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	0.665
EIF4E	ZFP36	ENSECAP00000052494	ENSECAP00000045220	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	Uncharacterized protein.	0.547
FBXO32	MSTN	ENSECAP00000013796	ENSECAP00000018852	F-box protein 32.	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	0.723
FBXO32	MYOD1	ENSECAP00000013796	ENSECAP00000001446	F-box protein 32.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.627
MSTN	FBXO32	ENSECAP00000018852	ENSECAP00000013796	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	F-box protein 32.	0.723
MSTN	MYOD1	ENSECAP00000018852	ENSECAP00000001446	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	0.777
MSTN	NR3C1	ENSECAP00000018852	ENSECAP00000033878	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	Nuclear receptor subfamily 3 group C member 1.	0.405
MYOD1	FBXO32	ENSECAP00000001446	ENSECAP00000013796	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	F-box protein 32.	0.627
MYOD1	MSTN	ENSECAP00000001446	ENSECAP00000018852	Myogenic factor; Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle- specific target genes and plays a role in muscle differentiation.	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	0.777
NR3C1	MSTN	ENSECAP00000033878	ENSECAP00000018852	Nuclear receptor subfamily 3 group C member 1.	Growth/differentiation factor 8; Acts specifically as a negative regulator of skeletal muscle growth; Belongs to the TGF-beta family.	0.405
PCK1	PCK2	ENSECAP00000011966	ENSECAP00000024976	Phosphoenolpyruvate carboxykinase 1.	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	0.908
PCK2	PCK1	ENSECAP00000024976	ENSECAP00000011966	Phosphoenolpyruvate carboxykinase 2, mitochondrial.	Phosphoenolpyruvate carboxykinase 1.	0.908
RPS6KB1	EIF4E	ENSECAP00000012006	ENSECAP00000052494	Ribosomal protein S6 kinase; Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.665
ZFP36	EIF4E	ENSECAP00000045220	ENSECAP00000052494	Uncharacterized protein.	Eukaryotic translation initiation factor 4E; Belongs to the eukaryotic initiation factor 4E family.	0.547
ZFP36L1	ZFP36L2	ENSECAP00000016390	ENSECAP00000015325	ZFP36 ring finger protein like 1.	ZFP36 ring finger protein like 2.	0.914
ZFP36L2	ZFP36L1	ENSECAP00000015325	ENSECAP00000016390	ZFP36 ring finger protein like 2.	ZFP36 ring finger protein like 1.	0.914