STRINGSTRING
LOC111772122 LOC111772122 TLR2 TLR2 CD1A1 CD1A1 TLR1 TLR1 CD1A3 CD1A3 LOC111767791 LOC111767791 TLR6 TLR6 CD1B2 CD1B2 CD1C CD1C CD1A7 CD1A7 CD1D CD1D CD1A5 CD1A5 CD1E2 CD1E2 CD14 CD14 CD1B1 CD1B1 ENSECAP00000036381 ENSECAP00000036381 CD1E1 CD1E1
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
LOC111772122Monocyte differentiation antigen CD14; Coreceptor for bacterial lipopolysaccharide. In concert with LBP, binds to monomeric lipopolysaccharide and delivers it to the LY96/TLR4 complex, thereby mediating the innate immune response to bacterial lipopolysaccharide (LPS). Acts via MyD88, TIRAP and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response. Acts as a coreceptor for TLR2:TLR6 heterodimer in response to diacylated lipopeptides and for TLR2:TLR1 heterodimer in response to triacylated lipopeptides, these clusters trigger signaling from the cell su [...] (369 aa)
TLR2Toll-like receptor 2; Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response (By similarity). May also promote apoptosis in response to lipoproteins. Forms activation clusters composed of several receptors depending on the ligand, these clusters trigger signaling from the cell surface and subsequentl [...] (784 aa)
CD1A1Ig-like domain-containing protein. (339 aa)
TLR1Toll-like receptor. (756 aa)
CD1A3Ig-like domain-containing protein. (347 aa)
LOC111767791CD14 molecule. (376 aa)
TLR6Toll-like receptor. (859 aa)
CD1B2Ig-like domain-containing protein. (410 aa)
CD1CIg-like domain-containing protein. (355 aa)
CD1A7Ig-like domain-containing protein. (340 aa)
CD1DIg-like domain-containing protein. (439 aa)
CD1A5CD1 protein. (349 aa)
CD1E2Ig-like domain-containing protein. (356 aa)
CD14CD14 molecule. (369 aa)
CD1B1CD1 protein. (333 aa)
ENSECAP00000036381TIR domain-containing protein; Belongs to the Toll-like receptor family. (772 aa)
CD1E1Ig-like domain-containing protein. (392 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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