STRINGSTRING
HS2ST1 HS2ST1 PTCH1 PTCH1 CALB1 CALB1 SMAD4 SMAD4 COMMD5 COMMD5 WNK4 WNK4 AQP1 AQP1 DLG2 DLG2 SOX8 SOX8 NOTCH2 NOTCH2 GLI3 GLI3 PKD1 PKD1 EYA1 EYA1 GDNF GDNF WNT9B WNT9B DLG1 DLG1 TMEM59L TMEM59L ILK ILK KIF26B KIF26B GREB1L GREB1L WT1 WT1 MEF2C MEF2C HES5 HES5 OSR1 OSR1 GATA3 GATA3 HES1 HES1 PKD2 PKD2 IRX3 IRX3 NOTCH1 NOTCH1 WNT11 WNT11 KLHL3 KLHL3 SOX9 SOX9 MTSS1 MTSS1 BMP2 BMP2 FGF1 FGF1 AHI1 AHI1 TCF21 TCF21 GREB1 GREB1 BMP4 BMP4 AQP11 AQP11 HNF1B HNF1B IRX2 IRX2 TFAP2B TFAP2B IRX1 IRX1 FGF2 FGF2 DLL1 DLL1 JAG1 JAG1 LGR4 LGR4 LZTS2 LZTS2 HOXA11 HOXA11 WNT6 WNT6 GZF1 GZF1 GPC3 GPC3 PAX8 PAX8 WNT1 WNT1 TACSTD2 TACSTD2 TFAP2E TFAP2E GREM1 GREM1 LHX1 LHX1 ADAMTS16 ADAMTS16
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
HS2ST1Uncharacterized protein. (356 aa)
PTCH1Patched 1. (1490 aa)
CALB1Calbindin 1. (261 aa)
SMAD4Mothers against decapentaplegic homolog. (552 aa)
COMMD5COMM domain containing 5. (222 aa)
WNK4WNK lysine deficient protein kinase 4. (1246 aa)
AQP1Uncharacterized protein; Belongs to the MIP/aquaporin (TC 1.A.8) family. (307 aa)
DLG2Discs large MAGUK scaffold protein 2. (975 aa)
SOX8SRY-box 8. (460 aa)
NOTCH2Notch receptor 2. (2471 aa)
GLI3GLI family zinc finger 3. (1581 aa)
PKD1Polycystin 1, transient receptor potential channel interacting. (4267 aa)
EYA1Eyes absent homolog; Belongs to the HAD-like hydrolase superfamily. EYA family. (621 aa)
GDNFGlial cell derived neurotrophic factor. (211 aa)
WNT9BProtein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (358 aa)
DLG1Discs large MAGUK scaffold protein 1; Belongs to the MAGUK family. (938 aa)
TMEM59LTransmembrane protein 59 like. (367 aa)
ILKIntegrin linked kinase. (452 aa)
KIF26BKinesin family member 26B; Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. (2183 aa)
GREB1LGREB1 like retinoic acid receptor coactivator. (1967 aa)
WT1WT1 transcription factor. (782 aa)
MEF2CMyocyte enhancer factor 2C. (483 aa)
HES5Hes family bHLH transcription factor 5. (164 aa)
OSR1Odd-skipped related transcription factor 1. (279 aa)
GATA3GATA binding protein 3. (445 aa)
HES1Hes family bHLH transcription factor 1. (280 aa)
PKD2Polycystin 2, transient receptor potential cation channel. (958 aa)
IRX3Iroquois homeobox 3. (498 aa)
NOTCH1Notch receptor 1. (2581 aa)
WNT11Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (354 aa)
KLHL3Kelch like family member 3. (601 aa)
SOX9SRY-box 9. (509 aa)
MTSS1MTSS I-BAR domain containing 1. (763 aa)
BMP2Bone morphogenetic protein 2. (397 aa)
FGF1Multifunctional fusion protein; Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integr [...] (155 aa)
AHI1Uncharacterized protein. (1219 aa)
TCF21Transcription factor 21. (179 aa)
GREB1Growth regulating estrogen receptor binding 1. (1951 aa)
BMP4Bone morphogenetic protein 4. (409 aa)
AQP11Aquaporin-11; Channel protein that facilitates the transport of water, glycerol and hydrogen peroxide across membrane of cell or organelles guaranteeing intracellular homeostasis in several organes like liver, kidney and brain. In situation of stress, participates in endoplasmic reticulum (ER) homeostasis by regulating redox homeostasis through the transport of hydrogen peroxide across the endoplasmic reticulum membrane thereby regulating the oxidative stress through the NADPH oxidase 2 pathway (By similarity). Plays a role by maintaining an environment suitable for translation or prot [...] (272 aa)
HNF1BHNF1 homeobox B. (558 aa)
IRX2Iroquois homeobox 2. (473 aa)
TFAP2BTranscription factor AP-2 beta. (469 aa)
IRX1Iroquois homeobox 1. (482 aa)
FGF2Fibroblast growth factor; Belongs to the heparin-binding growth factors family. (155 aa)
DLL1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (724 aa)
JAG1Delta-like protein; Putative Notch ligand involved in the mediation of Notch signaling. (1218 aa)
LGR4Leucine rich repeat containing G protein-coupled receptor 4. (1108 aa)
LZTS2Leucine zipper putative tumor suppressor 2; Negative regulator of katanin-mediated microtubule severing and release from the centrosome. Required for central spindle formation and the completion of cytokinesis. May negatively regulate axonal outgrowth by preventing the formation of microtubule bundles that are necessary for transport within the elongating axon. Negative regulator of the Wnt signaling pathway. Represses beta-catenin-mediated transcriptional activation by promoting the nuclear exclusion of beta- catenin. (670 aa)
HOXA11Homeobox A11. (316 aa)
WNT6Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (365 aa)
GZF1GDNF inducible zinc finger protein 1. (709 aa)
GPC3Glypican 3; Cell surface proteoglycan that bears heparan sulfate. Belongs to the glypican family. (611 aa)
PAX8Paired box 8. (457 aa)
WNT1Protein Wnt; Ligand for members of the frizzled family of seven transmembrane receptors; Belongs to the Wnt family. (370 aa)
TACSTD2Tumor associated calcium signal transducer 2. (333 aa)
TFAP2ETranscription factor AP-2 epsilon. (555 aa)
GREM1Gremlin 1, DAN family BMP antagonist. (143 aa)
LHX1LIM homeobox 1. (405 aa)
ADAMTS16ADAM metallopeptidase with thrombospondin type 1 motif 16. (1245 aa)
Your Current Organism:
Equus caballus
NCBI taxonomy Id: 9796
Other names: E. caballus, Equus przewalskii f. caballus, Equus przewalskii forma caballus, domestic horse, equine, horse
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